Difference between revisions of "Non-malignant skin disease"

Non-malignant skin disease (view source)

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 *Hyperkeratosis (more keratin - thick stratum corneum) - in "columns"; keratin in separate towers - ''not'' a flat thick sheet.
 *Hypergranulosis (thicker stratum granulosum).
-*Acanthosis (thickening of the stratum spinosum).
+*''Papillomatous hyperplasia'':
-**+/-Rete ridge lengthening (~7-10x normal) and thickening - ''papillomatous hyperplasia''.
+**Rete ridge lengthening (~7-10x normal) and thickening.
+**Rete ridge curvature toward the centre of the lesion (like the roads to the ''Palace of Versailles'') - '''important'''.
 *Large blood vessels at the dermal-epidermal junction - between the rete ridges.
-*+/-Viral changes - perinuclear halo, nucleus small and hyperchromatic<ref name=Ref_Derm106-7>{{Ref Derm|106-7}}</ref> - '''important''' when present.
+*+/-Viral changes - perinuclear halo, nucleus small and hyperchromatic<ref name=Ref_Derm106-7>{{Ref Derm|106-7}}</ref> - virtually '''diagnostic''' when present.
 **+/-Binucleation.