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Difference between revisions of "Non-invasive breast carcinoma"
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Non-invasive breast carcinoma (view source)
Revision as of 13:46, 24 August 2011
, 13:46, 24 August 2011→Is it ductal neoplasia?: +IHC
(→Size criteria for low-grade DCIS: tweak) |
(→Is it ductal neoplasia?: +IHC) |
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*DCIS = ductal carcinoma in situ. | *DCIS = ductal carcinoma in situ. | ||
====Tabular comparison==== | ====Tabular comparison - histomorphology==== | ||
Comparison of EHUT, ADH and DCIS (memory device: ''CLEAN'' = cell uniformity, luminal spaces, extent/size, arch., nuclei): | Comparison of EHUT, ADH and DCIS (memory device: ''CLEAN'' = cell uniformity, luminal spaces, extent/size, arch., nuclei): | ||
{| class="wikitable" | {| class="wikitable" | ||
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*Invasive ductal carcinoma - excision with sentinel lymph node biopsy (for staging)<ref>Sentinel Lymph Node Biopsy: What Breast Cancer Patients Need to Know. cancernews.com. URL: [http://www.cancernews.com/data/Article/202.asp http://www.cancernews.com/data/Article/202.asp]. Accessed on: 9 October 2009.</ref> and radiation. | *Invasive ductal carcinoma - excision with sentinel lymph node biopsy (for staging)<ref>Sentinel Lymph Node Biopsy: What Breast Cancer Patients Need to Know. cancernews.com. URL: [http://www.cancernews.com/data/Article/202.asp http://www.cancernews.com/data/Article/202.asp]. Accessed on: 9 October 2009.</ref> and radiation. | ||
*Positive sentinel node - systemic chemotherapy. (???) | *Positive sentinel node - systemic chemotherapy. (???) | ||
====IHC==== | |||
Usual ductal hyperplasia (AKA FEHUT) vs. [[ADH]]/[[DCIS]]:<ref>{{Cite journal | last1 = Rabban | first1 = JT. | last2 = Koerner | first2 = FC. | last3 = Lerwill | first3 = MF. | title = Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: a potentially difficult distinction resolved by cytokeratin 5/6. | journal = Hum Pathol | volume = 37 | issue = 7 | pages = 787-93 | month = Jul | year = 2006 | doi = 10.1016/j.humpath.2006.02.016 | PMID = 16784976 }}</ref><ref name=pmid19675450>{{Cite journal | last1 = Grin | first1 = A. | last2 = O'Malley | first2 = FP. | last3 = Mulligan | first3 = AM. | title = Cytokeratin 5 and estrogen receptor immunohistochemistry as a useful adjunct in identifying atypical papillary lesions on breast needle core biopsy. | journal = Am J Surg Pathol | volume = 33 | issue = 11 | pages = 1615-23 | month = Nov | year = 2009 | doi = 10.1097/PAS.0b013e3181aec446 | PMID = 19675450 }}</ref> | |||
*FEHUT: ER-low/CK5-high profile. | |||
*ADH/DCIS: ER-high/CK5-low. | |||
Where: | |||
*ER-high = diffuse strong staining in >90% of cells. | |||
*CK5-high = mosaic pattern of staining in >20% of cells | |||
*CK5-low = absent or staining in <20% of cells. | |||
==Atypical ductal hyperplasia== | ==Atypical ductal hyperplasia== | ||