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Difference between revisions of "Nodular fasciitis"
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| LMDDx = | | LMDDx = | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = CD34 -ve, desmin -ve, SMA -ve, S-100 -ve, AE1/AE3 -ve. | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = t(15;15) ? | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 29: | Line 29: | ||
}} | }} | ||
'''Nodular fasciitis''' is an uncommon [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]]. | '''Nodular fasciitis''' is an uncommon [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]]. | ||
==General== | |||
*Benign. | *Benign. | ||
*All age groups. | *All age groups. | ||
*Associated with trauma. | *Associated with trauma. | ||
==Microscopic== | |||
Features:<ref name=Ref_WMSP606>{{Ref WMSP|606}}</ref><ref>{{cite journal |author=de Feraudy S, Fletcher CD |title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases |journal=Am. J. Surg. Pathol. |volume=34 |issue=9 |pages=1377–81 |year=2010 |month=September |pmid=20716998 |doi=10.1097/PAS.0b013e3181ed7374 |url=}}</ref> | Features:<ref name=Ref_WMSP606>{{Ref WMSP|606}}</ref><ref>{{cite journal |author=de Feraudy S, Fletcher CD |title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases |journal=Am. J. Surg. Pathol. |volume=34 |issue=9 |pages=1377–81 |year=2010 |month=September |pmid=20716998 |doi=10.1097/PAS.0b013e3181ed7374 |url=}}</ref> | ||
*Usu. well-circumscribed. | *Usu. well-circumscribed. | ||
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www: | www: | ||
*[http://www.humpath.com/nodular-fasciitis NF (humpath.com)]. | *[http://www.humpath.com/nodular-fasciitis NF (humpath.com)]. | ||
==IHC== | |||
Routine spindle cell panel: | Routine spindle cell panel: | ||
*CD34 -ve. | *CD34 -ve. | ||
*Desmin -ve. | *Desmin -ve. | ||
*SMA -ve. | *SMA -ve. | ||
* | *S-100 -ve. | ||
*AE1/AE3 -ve. | *AE1/AE3 -ve. | ||
| Line 86: | Line 86: | ||
*Vimentin +ve. | *Vimentin +ve. | ||
==Molecular== | |||
*Evolving - case reports. | *Evolving - case reports. | ||
**t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal |author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z |title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region |journal=Cancer Genet. Cytogenet. |volume=141 |issue=2 |pages=160–3 |year=2003 |month=March |pmid=12606136 |doi= |url=}}</ref> | **t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal |author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z |title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region |journal=Cancer Genet. Cytogenet. |volume=141 |issue=2 |pages=160–3 |year=2003 |month=March |pmid=12606136 |doi= |url=}}</ref> | ||