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Difference between revisions of "Neuropathology tumours"
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==Astrocytomas== | ==Astrocytomas== | ||
* | *Pilocytic astrocytomas (WHO Grade I). | ||
* | *Dysembryoplastic neuroepithelial tumour (DNT), (WHO Grade I). | ||
* | *Low-grade (diffuse) astrocytomas (Grade II). | ||
* | *Anaplastic astrocytomas (Grade III). | ||
* | *Glioblastoma (Grade IV). | ||
Features:<ref name=pmid>{{cite journal |author=Rong Y, Durden DL, Van Meir EG, Brat DJ |title='Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis |journal=J. Neuropathol. Exp. Neurol. |volume=65 |issue=6 |pages=529–39 |year=2006 |month=June |pmid=16783163 |doi= |url=}}</ref><ref>[http://dictionary.reference.com/browse/palisading http://dictionary.reference.com/browse/palisading]</ref> | Features:<ref name=pmid>{{cite journal |author=Rong Y, Durden DL, Van Meir EG, Brat DJ |title='Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis |journal=J. Neuropathol. Exp. Neurol. |volume=65 |issue=6 |pages=529–39 |year=2006 |month=June |pmid=16783163 |doi= |url=}}</ref><ref>[http://dictionary.reference.com/browse/palisading http://dictionary.reference.com/browse/palisading]</ref> | ||
*Nuclear pleomorphism | *Nuclear pleomorphism. | ||
*Mitotic figures | *Mitotic figures. | ||
*Microvascular proliferation or necrosis with pseudopalisading tumour cells. | *Microvascular proliferation or necrosis with pseudopalisading tumour cells. | ||
**Pseudopalisading tumour cells = high tumour cell density adjacent to regions of necrosis; palisade = a fence of pales forming a defense barrier or fortification. | **Pseudopalisading tumour cells = high tumour cell density adjacent to regions of necrosis; palisade = a fence of pales forming a defense barrier or fortification. | ||
==Pilocytic astrocytoma== | ==Pilocytic astrocytoma== | ||
Gross | Gross: | ||
*Do NOT smear. | *Do NOT smear. | ||
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==Peripheral nerve sheath tumours== | ==Peripheral nerve sheath tumours== | ||
A classification:<ref name=pmid17893219>{{cite journal |author=Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A |title=Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns |journal=AJNR Am J Neuroradiol |volume=28 |issue=9 |pages=1633–8 |year=2007 |month=October |pmid=17893219 |doi=10.3174/ajnr.A0682 |url=http://www.ajnr.org/cgi/reprint/28/9/1633}}</ref> | A classification:<ref name=pmid17893219>{{cite journal |author=Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A |title=Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns |journal=AJNR Am J Neuroradiol |volume=28 |issue=9 |pages=1633–8 |year=2007 |month=October |pmid=17893219 |doi=10.3174/ajnr.A0682 |url=http://www.ajnr.org/cgi/reprint/28/9/1633}}</ref> | ||
*Benign | *Benign: | ||
**Schwannoma | **Schwannoma. | ||
**Neurofibroma | **Neurofibroma. | ||
**Perineurioma | **Perineurioma. | ||
**Traumatic neuroma | **Traumatic neuroma. | ||
*Malignant | *Malignant: | ||
**Malignant peripheral nerve sheath tumour (MPNST) | **Malignant peripheral nerve sheath tumour (MPNST). | ||
==Schwannoma== | ==Schwannoma== | ||
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====Antoni A==== | ====Antoni A==== | ||
*Cellular. | *Cellular. | ||
*' | *'Fibrillary, polar, elongated'. | ||
Comment: May look somewhat like scattered matchsticks. | Comment: May look somewhat like scattered matchsticks. | ||
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*Papillae. | *Papillae. | ||
*Psammoma bodies. | *Psammoma bodies. | ||
==References== | ==References== | ||