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Difference between revisions of "Neuropathology tumours"
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→Common brain tumours in a table
| Line 71: | Line 71: | ||
|'''Images''' | |'''Images''' | ||
|- | |- | ||
|Normal | |Normal tissue | ||
|regular spacing, no atypia | |regular spacing, no atypia | ||
|small lesion? | |small lesion? | ||
| Line 88: | Line 88: | ||
|- | |- | ||
|Astrocytoma | |Astrocytoma | ||
|glial processes (on smear), nuclear atypia | |glial processes (on smear), nuclear atypia (size var. ~3x, irreg. nuc. membrane, hyperchromasia) | ||
|enhancing, usu. supratentorial, usu. white matter | |enhancing, usu. supratentorial, usu. white matter | ||
|usu. old, occ. young | |usu. old, occ. young | ||
|very common | |very common, esp. glioblastoma | ||
|IDH-1+/- | |IDH-1+/- | ||
|[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg] | |[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg] | ||
|- | |- | ||
|Metastasis | |Metastasis | ||
|sharp interface with brain, often glandular, nucleoli | |sharp interface with brain, often glandular, +/-nucleoli, no glial processes | ||
|often cerebellular, well-circumscribed | |often cerebellular, well-circumscribed | ||
|usu. old | |usu. old | ||
|often suspected | |often suspected to have metastatic disease | ||
|TTF-1, CK7, CK20 | |TTF-1, CK7, CK20 | ||
|[http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg], [http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg] | |[http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg], [http://commons.wikimedia.org/w/index.php?title=File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg] | ||
| Line 107: | Line 107: | ||
|extra-axial + intradural | |extra-axial + intradural | ||
|old or young | |old or young | ||
| | |may be diagnosed on smear, DDx: choroid plexus, schwannoma | ||
|EMA, PR, Ki-67 | |EMA, PR, Ki-67 | ||
|[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg] | |[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg] | ||
|- | |- | ||
|Schwannoma | |Schwannoma | ||
|cellular areas (Antoni A), paucicelluar areas (Antoni B) | |cellular areas (Antoni A), paucicelluar areas (Antoni B), palisading of nuclei (Verocay bodies) | ||
|extra-axial + intradural | |extra-axial + intradural | ||
|old or young | |old or young | ||