Difference between revisions of "Neuropathology"

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Neuropathology (view source)

Revision as of 06:06, 13 November 2010

1,926 bytes added ,  06:06, 13 November 2010
→‎Histopathology: +images, descriptions
(→‎Histopathology: +images, descriptions)
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*Rosette = circular/flower-like arrangement of cells<ref name=pmid16551982>PMID 16551982</ref>
*Rosette = circular/flower-like arrangement of cells<ref name=pmid16551982>PMID 16551982</ref>
*Pseudorosette = circular/flower-like arrangement of cells with blood vessel at the centre<ref name=pmid16551982>PMID 16551982</ref>
*Pseudorosette = circular/flower-like arrangement of cells with blood vessel at the centre<ref name=pmid16551982>PMID 16551982</ref>
*Rosenthal fibres = worm-like or corkscrew-like eosinophilic bodies.
*Rosenthal fibres = worm-like or corkscrew-like (brightly) eosinophilic bodies; 10-40 micrometers.
*Eosinophilic granular bodies = related to Rosenthal fibres; round cytoplasmic hyaline droplets in astrocytes.<ref>{{Ref MBNP|11}}</ref>
**Image: [http://en.wikipedia.org/wiki/File:Rosenthal_HE_40x.jpg Rosenthal fibres (WP)].
**Image: [http://en.wikipedia.org/wiki/File:Rosenthal_HE_40x.jpg Rosenthal fibres (WP)].
*Pseudopallisading
*Pseudopallisading
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|-  
|-  
| Lewy body  
| Lewy body  
| cytoplasmic thingy
| round cytoplasmic eosinophilic<br> body +/- pale halo
| Lewy body dementia
| Parkinsons disease, dementia with Lewy bodies
| ?Comment
| morphology dependent on <br>location in brain; +ve for alpha-synuclein, <br>alpha-B crystallin, ubiquitin
| [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG]
| [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG]
|-  
|-  
| Lafora body
| Lafora body
| concentric calcification
| round
| ?Associated disease
| myoclonic epilepsy
| look like corpora amylacea  
| look like corpora amylacea; location: dentate nucleus, liver, skeletal muscle, sweat glands
| ?Image
| ?Image
|-  
|-  
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|-  
|-  
| Hirano body
| Hirano body
| ?Appearance
| concentric calcification/rod-shaped bright eosinophilic; overlap edge of neuron
| ALS, Parkinson's disease
| Alzheimer d., Pick d.<ref name=Ref_MBNP5>{{Ref MBNP|5}}</ref>
| actin crystals, may look like capillaries
| actin crystals, may look like capillaries; location: CA1 of hippocampus
| ?Image
| [http://faculty.washington.edu/alexbert/MEDEX/Fall/adhirano.jpg]<ref name=pakmednet>URL: [http://www.pakmed.net/academic/age/alz/alz030.htm http://www.pakmed.net/academic/age/alz/alz030.htm]. Accessed on: 12 November 2010.</ref>
|-
|-
| Neurofibrillary tangles
| Neurofibrillary tangles
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| aging, Alzheimer's disease
| aging, Alzheimer's disease
| seen with silver stain
| seen with silver stain
| [https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/tangle.gif]<ref>URL: [https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/ANGEL.HTM https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/ANGEL.HTM]. Accessed on: 12 November 2010.</ref>, [http://www.pakmed.net/academic/age/alz/plaques_tanglesBorder.jpg Schematic]<ref>URL: [http://www.pakmed.net/academic/age/alz/alz030.htm http://www.pakmed.net/academic/age/alz/alz030.htm]. Accessed on: 12 November 2010.</ref>
| [https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/tangle.gif]<ref>URL: [https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/ANGEL.HTM https://sharepoint.cisat.jmu.edu/isat/klevicca/Web/ISAT280/ANGEL.HTM]. Accessed on: 12 November 2010.</ref>, [http://www.pakmed.net/academic/age/alz/plaques_tanglesBorder.jpg Schematic]<ref name=pakmednet>URL: [http://www.pakmed.net/academic/age/alz/alz030.htm http://www.pakmed.net/academic/age/alz/alz030.htm]. Accessed on: 12 November 2010.</ref>, [http://faculty.washington.edu/alexbert/MEDEX/Fall/adtangle.jpg]<ref name=alexbert>URL: [http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm]. Accessed on: 13 November 2010.</ref>
|-
| Granulovacuolar degeneration
| cytoplasmic vacuoles 4-5 micrometers
| ageing, Alzheimer's disease, <br>Pick's disease
| main found in Ammon horn<ref name=Ref_MBNP5>{{Ref MBNP|5}}</ref>
| [http://faculty.washington.edu/alexbert/MEDEX/Fall/adgvd.jpg]<ref name=alexbert>URL: [http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm]. Accessed on: 13 November 2010.</ref>
|-  
|-  
| Pick bodies
| Pick bodies
| ?Appearance
| round, homogenous, intracytoplasmic, ~10 micrometers
| ?Associated disease
| Pick's disease
| ?Comment
| pyramidal neurons, dentate <br>granule cells (hippocampus); +ve for tau, tubulin, ubiquitin
| ?Image
| [http://s212.photobucket.com/albums/cc74/cat_at_uw/Osler%20-%20Neuropath/?action=view&current=Picks60x.jpg&mediafilter=images]
|-  
|-  
| Bunina body
| Bunina body
| size of Nissl granules
| size of Nissl granules, eosinophilic
| ?Associated disease
| ALS
| ?Comment
| EM: membrane-bound bodies; ubiquitin +ve
| ?Image
| [http://pathol.umin.ac.jp/gakubu/exam/2006jpg/19.jpg]
|-  
|-  
<!-- | Feature  
<!-- | Feature  
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Image collection: [http://s212.photobucket.com/albums/cc74/cat_at_uw/Osler%20-%20Neuropath/?mediafilter=images Inclusion bodies (photobucket.com)].


==Immunohistochemistry==
==Immunohistochemistry==
Michael
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