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Difference between revisions of "Neuropathology"
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→Progressive multifocal leukoencephalopathy: more
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*Caused by ''JC virus'' (a type of [[polyomavirus]]<ref name=pmid21499097>{{Cite journal | last1 = Berger | first1 = JR. | title = The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. | journal = Curr Opin Neurol | volume = 24 | issue = 3 | pages = 262-7 | month = Jun | year = 2011 | doi = 10.1097/WCO.0b013e328346d2a3 | PMID = 21499097 }}</ref>) in the context of immunodeficiency; usu. in the setting of [[HIV]] infection.<ref name=pmid12709870>{{Cite journal | last1 = Berger | first1 = JR. | title = Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. | journal = J Neurovirol | volume = 9 Suppl 1 | issue = | pages = 38-41 | month = | year = 2003 | doi = 10.1080/13550280390195261 | PMID = 12709870 }}</ref> | *Caused by ''JC virus'' (a type of [[polyomavirus]]<ref name=pmid21499097>{{Cite journal | last1 = Berger | first1 = JR. | title = The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. | journal = Curr Opin Neurol | volume = 24 | issue = 3 | pages = 262-7 | month = Jun | year = 2011 | doi = 10.1097/WCO.0b013e328346d2a3 | PMID = 21499097 }}</ref>) in the context of immunodeficiency; usu. in the setting of [[HIV]] infection.<ref name=pmid12709870>{{Cite journal | last1 = Berger | first1 = JR. | title = Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. | journal = J Neurovirol | volume = 9 Suppl 1 | issue = | pages = 38-41 | month = | year = 2003 | doi = 10.1080/13550280390195261 | PMID = 12709870 }}</ref> | ||
**Approximately 5% of HIV patients develop PML.<ref name=pmid12709870/> | **Approximately 5% of HIV patients develop PML.<ref name=pmid12709870/> | ||
**Virus destroys oligodendrocytes -> demyelination results.<ref name=pmid21823157>{{Cite journal | last1 = Mateen | first1 = FJ. | last2 = Muralidharan | first2 = R. | last3 = Carone | first3 = M. | last4 = van de Beek | first4 = D. | last5 = Harrison | first5 = DM. | last6 = Aksamit | first6 = AJ. | last7 = Gould | first7 = MS. | last8 = Clifford | first8 = DB. | last9 = Nath | first9 = A. | title = Progressive multifocal leukoencephalopathy in transplant recipients. | journal = Ann Neurol | volume = 70 | issue = 2 | pages = 305-22 | month = Aug | year = 2011 | doi = 10.1002/ana.22408 | PMID = 21823157 }} | |||
</ref> | |||
===Gross=== | |||
*Multifocal - as the name suggests. | |||
===Microscopic=== | ===Microscopic=== | ||