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Difference between revisions of "Neuromuscular pathology"
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Neuromuscular pathology (view source)
Revision as of 03:40, 29 October 2010
, 03:40, 29 October 2010→Inclusion body myositis
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===General=== | ===General=== | ||
*Usually elderly. | *Usually elderly. | ||
*Thought to be related to Alzheimer's disease due to similar staining with congo red and several [[IHC]] stains.<ref name=pmid8579968>{{cite journal |author=Askanas V, Engel WK |title=New advances in the understanding of sporadic inclusion-body myositis and hereditary inclusion-body myopathies |journal=Curr Opin Rheumatol |volume=7 |issue=6 |pages=486–96 |year=1995 |month=November |pmid=8579968 |doi= |url=}}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Inflammation. | *Inflammation. | ||
*Vacuolated fibres (with proteineous aggregates) | *Vacuolated muscle fibres (with proteineous aggregates) '''key feature'''. | ||
**Vacuolation = "inclusion" | |||
***Usually in the centroidal location. | |||
DDx: polymyositis. | DDx: polymyositis. | ||
IHC: APP +ve, ubiquitin +ve, tau +ve. | ===IHC=== | ||
Features:<ref name=pmid8579968/> | |||
*Congo red +ve. | |||
*APP +ve, ubiquitin +ve, tau +ve. (???) | |||
==Polymyositis== | ==Polymyositis== | ||