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Difference between revisions of "Neuromuscular pathology"
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Neuromuscular pathology (view source)
Revision as of 03:34, 27 October 2010
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| groups <br>("group atrophy") | | groups <br>("group atrophy") | ||
| singular | | singular | ||
| | | | ||
| [http://neuropathology.neoucom.edu/chapter9/images9/13-7.jpg group atrophy]<ref>URL: [http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html]. Accessed on: 25 October 2010.</ref> | | [http://neuropathology.neoucom.edu/chapter9/images9/13-7.jpg group atrophy]<ref>URL: [http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html http://neuropathology.neoucom.edu/chapter9/chapter9fALS.html]. Accessed on: 25 October 2010.</ref> | ||
|- | |- | ||
| Line 39: | Line 39: | ||
| No | | No | ||
| +/-Scattered | | +/-Scattered | ||
| "hypercontracted fibres" | | "hypercontracted<br>fibres" | ||
| [http://commons.wikimedia.org/wiki/File:Duchenne-muscular-dystrophy.jpg DMD (WC)] | | [http://commons.wikimedia.org/wiki/File:Duchenne-muscular-dystrophy.jpg DMD (WC)] | ||
|- | |||
| Fibre type<br>grouping | |||
| yes (d/t chronic <br>denervation + <br>reinnervation)<ref>URL: [http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype http://neuromuscular.wustl.edu/lab/mbiopsy.htm#fibertype]. Accessed on: 26 October 2010.</ref> | |||
| yes (???) | |||
| based on ATPase, NADH-TR stains | |||
| [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/subpages/ng.atp.9.4.1.html]<ref>URL: [http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html http://missinglink.ucsf.edu/lm/ids_104_musclenerve_path/student_musclenerve/musclepath.html]. Accessed on: 26 October 2010.</ref> | |||
|} | |} | ||
| Line 117: | Line 123: | ||
==Stains for muscle biopsies== | ==Stains for muscle biopsies== | ||
===Standard=== | |||
{| class="wikitable" | |||
| '''Stain''' | |||
| '''Comment''' | |||
| '''Image''' | |||
|- | |||
| H&E stain | |||
| routine | |||
| [http://www.rvc.ac.uk/Research/Labs/NeuroLab/images/HE.jpg]<ref>URL: [http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm]. Accessed on: 26 October 2010.</ref> | |||
|- | |||
| Gomori trichrome | |||
| good for nemaline rods, <br>mitochondrial pathology (appear red) | |||
| [http://commons.wikimedia.org/wiki/File:Modified_Gomori_trichrome_stain_showing_several_ragged_red_fibers_.jpg] | |||
|- | |||
| PAS | |||
| glycogen storage disorders | |||
| [http://neuromuscular.wustl.edu/pics/biopsy/dm/dermatopas.jpg]<ref>URL: [http://neuromuscular.wustl.edu/pathol/dermmyo.htm http://neuromuscular.wustl.edu/pathol/dermmyo.htm]. Accessed on: 26 October 2010.</ref> | |||
|- | |||
| Congo red | |||
| find [[amyloid]]; seen in<br>inclusion body myositis | |||
| [http://neuromuscular.wustl.edu/pics/biopsy/lgd/ibmpaget/hppagetibmvaccr2.jpg]<ref>URL: [http://neuromuscular.wustl.edu/pathol/ibmpaget.htm http://neuromuscular.wustl.edu/pathol/ibmpaget.htm]. Accessed on: 26 October 2010.</ref> | |||
|- | |||
| Oil red O | |||
| lipid more in<br> type 1 fibres | |||
| | |||
|- | |||
| ATPase pH4.2<br>ATPase pH9.4 | |||
| should have "checkerboard <br>pattern" in normal; see table below | |||
| [http://neuromuscular.wustl.edu/pics/biopsy/dm/dermatopfatp94.jpg]<ref>URL: [http://neuromuscular.wustl.edu/pathol/dermmyo.htm http://neuromuscular.wustl.edu/pathol/dermmyo.htm]. Accessed on: 26 October 2010.</ref> | |||
|- | |||
| NADH-TR | |||
| should have "checkerboard <br>pattern" in normal | |||
| | |||
|} | |||
Special - mitochondrial pathology.: | Special - mitochondrial pathology.: | ||
*SDH. | *SDH (Succinate dehydrogenase). | ||
*COX. | *COX. | ||
*COX-SDH. | *COX-SDH. | ||
| Line 138: | Line 169: | ||
Dunno: | Dunno: | ||
*Toluidine blue. | *Toluidine blue - myopathies. | ||
**Image: [http://neuromuscular.wustl.edu/pics/biopsy/rods/rodhptb2.jpg Nemaline rods (wustl.edu)].<ref>URL: [http://neuromuscular.wustl.edu/pathol/rod.htm http://neuromuscular.wustl.edu/pathol/rod.htm]. Accessed on: 26 October 2010.</ref> | |||
IHC: | IHC: | ||
| Line 294: | Line 326: | ||
==External links== | ==External links== | ||
*[http://moon.ouhsc.edu/kfung/jty1/NeuroHelp/ZNEWWU10.htm How to work up a muscle biopsy (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/NeuroHelp/ZNEWWU10.htm How to work up a muscle biopsy (ouhsc.edu)]. | ||
*[http://neuromuscular.wustl.edu/lab/mbiopsy.htm Muscle biopsies (wustl.edu)]. | |||
[[Category:Neuropathology]] | [[Category:Neuropathology]] | ||