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Neuromuscular pathology (view source)
Revision as of 14:10, 21 October 2019
, 14:10, 21 October 2019→Other Diseases: TTR polyneuropathy
Jensflorian (talk | contribs) (→Inflammation: Vasculitis) |
Jensflorian (talk | contribs) (→Other Diseases: TTR polyneuropathy) |
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*Endoneurial and epineurial mircrovessels, arterioles and venules. | *Endoneurial and epineurial mircrovessels, arterioles and venules. | ||
*Ischemia of nerve: thrombosis and fibrinoid necrosis. | *Ischemia of nerve: thrombosis and fibrinoid necrosis. | ||
*Medium-sized epineurial vessels: mostly classic polyarteritis nodosa. | *Signs of previous vasculitis: Vessel narrowing, fragmentation of elastica, fibrous obliteration and recanalization. | ||
*Small and medium-sized vessels and eosinophilia: Churg-Strauss angitis. | *Often nerve involvement in systemic vasculitis: | ||
*Small vessels and necrotizing: ANCA-associated microscopic polyangitis. | **Medium-sized epineurial vessels: mostly classic polyarteritis nodosa. | ||
**Small and medium-sized vessels and eosinophilia: Churg-Strauss angitis. | |||
**Small vessels and necrotizing: ANCA-associated microscopic polyangitis. | |||
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===Other Diseases=== | ===Other Diseases=== | ||
*Amyloid neuropathy: Amorphic endoneurial deposits. | |||
**TTR amyloidosis is of specific interest, because treatment options exist.<ref>{{Cite journal | last1 = Adams | first1 = D. | last2 = Koike | first2 = H. | last3 = Slama | first3 = M. | last4 = Coelho | first4 = T. | title = Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease. | journal = Nat Rev Neurol | volume = 15 | issue = 7 | pages = 387-404 | month = Jul | year = 2019 | doi = 10.1038/s41582-019-0210-4 | PMID = 31209302 }}</ref> | |||
**Example of amyloid deposits [https://www.nature.com/articles/s41582-019-0210-4/figures/3 here] | |||
*Neuropathy associated with paraproteinemia: Alterations in myelin periodicity, nerve fiber loss. | |||
**[[MGUS]] - Monoclonal gammopathy of unknown significance. | |||
** Multiple myeloma. | |||
**[[POEMS]] syndrome. | |||
**[[LCDD]] - light chain deposition diesease. | |||
*Toxic polyneuropathy (drug toxicity).<ref>URL: [http://path.upmc.edu/cases/case173.html http://path.upmc.edu/cases/case173.html]. Accessed on: 8 January 2012.</ref> | *Toxic polyneuropathy (drug toxicity).<ref>URL: [http://path.upmc.edu/cases/case173.html http://path.upmc.edu/cases/case173.html]. Accessed on: 8 January 2012.</ref> | ||
*Polyglucosan body disease. | *Polyglucosan body disease. | ||