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Difference between revisions of "Neuromuscular pathology"
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Neuromuscular pathology (view source)
Revision as of 17:41, 22 January 2011
, 17:41, 22 January 2011link to images
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Others: | Others: | ||
*Target fibre - "hole in middle of myofibres" = neurogenic. ( | *Target fibre - "hole in middle of myofibres" = neurogenic. | ||
**Images: [http://commons.wikimedia.org/w/index.php?title=File:Denervation_atrophy_-_very_high_mag.jpg Target fibres - very high mag. (WC)], [Target fibres - SDH stain - very high mag. (WC)]. | |||
*Cores - central pale area along length of fibres = myopathic. (???) | *Cores - central pale area along length of fibres = myopathic. (???) | ||
**Image: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNN0IE08-core-NADHb.htm Cores (ouhsc.edu)]. | **Image: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNN0IE08-core-NADHb.htm Cores (ouhsc.edu)]. | ||
| Line 188: | Line 189: | ||
| H&E stain | | H&E stain | ||
| routine | | routine | ||
| [http://www.rvc.ac.uk/Research/Labs/NeuroLab/images/HE.jpg]<ref>URL: [http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm]. Accessed on: 26 October 2010.</ref> | | [http://www.rvc.ac.uk/Research/Labs/NeuroLab/images/HE.jpg H&E]<ref>URL: [http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm http://www.rvc.ac.uk/Research/Labs/NeuroLab/MuscleBiopsy.cfm]. Accessed on: 26 October 2010.</ref>, [http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_very_high_mag.jpg H&E (WC)] | ||
|- | |- | ||
| Gomori trichrome | | Gomori trichrome | ||
| good for nemaline rods, <br>mitochondrial pathology<br>(ragged red fibres - at edge <br>of myocyte) | | good for nemaline rods, <br>mitochondrial pathology<br>(ragged red fibres - at edge <br>of myocyte) | ||
| [http://commons.wikimedia.org/wiki/File:Modified_Gomori_trichrome_stain_showing_several_ragged_red_fibers_.jpg] | | [http://commons.wikimedia.org/wiki/File:Modified_Gomori_trichrome_stain_showing_several_ragged_red_fibers_.jpg RRF (WC)] | ||
|- | |- | ||
| PAS | | PAS | ||
| Line 204: | Line 205: | ||
| Oil red O | | Oil red O | ||
| lipid more in<br> type 1 fibres | | lipid more in<br> type 1 fibres | ||
| | | [http://moon.ouhsc.edu/kfung/jty1/Composites/FNEWWU10-lipid-storage.htm ORO] | ||
|- | |- | ||
| ATPase pH4.2<br>ATPase pH9.4 | | ATPase pH4.2<br>ATPase pH9.4 | ||
| Line 238: | Line 239: | ||
|Succinate <br>dehydrogenase (SDH) | |Succinate <br>dehydrogenase (SDH) | ||
| | | | ||
| [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-03.gif]<ref name=ouhsc1>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref> | | [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com04Image/Com401-3-03.gif]<ref name=ouhsc1>URL: [http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm http://moon.ouhsc.edu/kfung/JTY1/Com04/Com401-3-Diss.htm]. Accessed on: 28 October 2010.</ref>, [http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_sdh_-_high_mag.jpg SDH (WC)] | ||
|- | |- | ||
|COX | |COX | ||
| Line 294: | Line 295: | ||
DDx: | DDx: | ||
#Polymyositis. | #Polymyositis. | ||
#*Disease of adults. | |||
#Inclusion body myositis (IBM). | #Inclusion body myositis (IBM). | ||
#Dermatomyositis. | #Dermatomyositis. | ||
#*May be associated with malignancy. | |||
===Partial invasion of muscle fibres=== | ===Partial invasion of muscle fibres=== | ||
DDx:<ref name=inflam_wustledu>URL: [http://neuromuscular.wustl.edu/pathol/inflammation.htm#cellinv http://neuromuscular.wustl.edu/pathol/inflammation.htm#cellinv]. Accessed on: 3 November 2010.</ref> | DDx:<ref name=inflam_wustledu>URL: [http://neuromuscular.wustl.edu/pathol/inflammation.htm#cellinv http://neuromuscular.wustl.edu/pathol/inflammation.htm#cellinv]. Accessed on: 3 November 2010.</ref> | ||
*Polymyositis. | |||
*IBM. | *IBM. | ||
Images: | Images: | ||
| Line 414: | Line 417: | ||
==Myotonic dystrophy== | ==Myotonic dystrophy== | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
| Line 437: | Line 439: | ||
Notes: | Notes: | ||
*Can be demonstrated with IHC. | *Can be demonstrated with [[IHC]]. | ||
===DDx=== | ===DDx=== | ||
| Line 473: | Line 475: | ||
*Steroids. | *Steroids. | ||
*Others. | *Others. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_high_mag.jpg Denervation atrophy - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_atp94_-_high_mag.jpg Type 2 fibre atrophy - ATPase pH 9.4 - high mag. (WC)]. | |||
==Nerve stuff== | ==Nerve stuff== | ||