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===WHO classification of 2017=== | ===WHO classification of 2017=== | ||
Five | Five categories:<!-- https://www.esp-congress.org/fileadmin/user_upload/Congress_2016/IAP_ESP_Presentations/Mon/0830-1200/SY-02/SY-02-004-Kl%C3%B6ppel-Update%20of%20WHO%20classification%20of%20endocrine%20pancreatic%20tumours.pdf --> | ||
* | *NET G1. Ki67 Index < 3%, Mitotic Index < 2/10HPF | ||
* | *NET G2. Ki67 Index 3-20%, Mitotic Index 2-20/10HPF | ||
* | *NET G3. Ki67 Index > 20%, Mitotic Index > 20/10 HPF AND well-differentiated, expressing neuroendocrine differentiation and hormones | ||
*Neuroendocrine carcinoma. | *Neuroendocrine carcinoma (NEC G3). Ki 67 Index > 20%, Mitotic Index > 20/10 HPF Poorly differentiated, expressing neuroendocrine differentiation but lacking exocrine markers. | ||
*[[MiNEN]]. | *[[MiNEN]]. mixed endocrine-nonendocrine neoplasm: components of a non-endocrine carcinoma (mostly ductal adenocarcinoma or acinar cell carcinoma) combined with a neuroendocrine neoplasm | ||
===Classification by product=== | ===Classification by product=== | ||
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*Synaptophysin +ve. | *Synaptophysin +ve. | ||
*CD56 +ve. | *CD56 +ve. | ||
*[[PAX8]] +ve (74% of cases<ref name=pmid20890270>{{Cite journal | last1 = Sangoi | first1 = AR. | last2 = Ohgami | first2 = RS. | last3 = Pai | first3 = RK. | last4 = Beck | first4 = AH. | last5 = McKenney | first5 = JK. | last6 = Pai | first6 = RK. | title = PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. | journal = Mod Pathol | volume = 24 | issue = 3 | pages = 412-24 | month = Mar | year = 2011 | doi = 10.1038/modpathol.2010.176 | PMID = 20890270 }}</ref>). | |||
Functional tumours: | Functional tumours: |
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