Difference between revisions of "Neurodegenerative diseases"

Neurodegenerative diseases (view source)

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→‎Other: NIFID, BIBD

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 *[http://www.nature.com/nrneurol/journal/v6/n2/fig_tab/nrneurol.2009.216_F1.html Pick body (nature.com)].<ref name=pmid20139998>{{Cite journal  | last1 = Grossman | first1 = M. | title = Primary progressive aphasia: clinicopathological correlations. | journal = Nat Rev Neurol | volume = 6 | issue = 2 | pages = 88-97 | month = Feb | year = 2010 | doi = 10.1038/nrneurol.2009.216 | PMID = 20139998 }}</ref>
+=FUSopathies (FTLD-FUS)=
+* Clinical manifestations depend on the distribution of the pathologic alterations in the CNS
+* Currently 3 disorders among the FTLD-FUS subgroup.
+* In contrast to ALS-FUS, no genetic alterations of FUS have been reported to date for cases within the FTLD-FUS group.
+DDx (also FUS+ve):
+*Spinocerebellar Ataxia (SCA)
+*Huntington Disease (SD)
+==Basophilic inclusion body disease==
+* AKA: BIBD.
+* Variable clinic (behavioral, cognitive alterations, parkinsonism, motor neuron diseases, ALS-like).
+* Age of onset: 35-70 years.
+* Intraneuronal cytoplasmic basophilic inclusion bodies.
+* FUS+ve (universally).
+* TAF15+ve
+* alpha-Internexin+ve.
+==Neuronal Intermediate Filament Inclusion Disease==
+* AKA: NIFID.
+* Hyaline conglomerates (brightly eosinophilic branching fibrillar structures embedded in a round, well-delineated, glassy vacuole).
+* FUS+ve (heterogenous).
+* Ubiquitin +/-ve.
+* NF +ve (some subunits).
+* p62 +/-ve.
+* TDP43-ve.
+* Tau-ve.
+* α-synuclein-ve.
 =Other=