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Difference between revisions of "Nephrogenic adenoma"
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| Caption = Nephrogenic adenoma. [[H&E stain]]. | | Caption = Nephrogenic adenoma. [[H&E stain]]. | ||
| Synonyms = mesonephric adenoma, nephrogenic metaplasia | | Synonyms = mesonephric adenoma, nephrogenic metaplasia | ||
| Micro = tubular structures with a microcystic appearance lined by [[hobnail]]ed cells +/-thick eosinophilic basement membrane, usually associated with chronic inflammation | | Micro = classically tubular structures with a microcystic appearance lined by [[hobnail]]ed cells +/-thick eosinophilic basement membrane; may have tubulocystic, polypoid, papillary or fibromyxoid architecture; usually associated with chronic inflammation | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | | LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | ||
*Tubular structures - | *Tubular structures - the classic morphology. † | ||
**Lined by a single cell layer - classically [[hobnail]]ed. ‡ | **Lined by a single cell layer - classically [[hobnail]]ed. ‡ | ||
**+/-Thick eosinophilic basement membrane. | **+/-Thick eosinophilic basement membrane. | ||
| Line 90: | Line 90: | ||
*[[AMACR]] +ve/-ve. | *[[AMACR]] +ve/-ve. | ||
Others:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 }}</ref> | Others:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | ||
*p53 -ve. | *p53 -ve. | ||
*[[CEA]] -ve. | *[[CEA]] -ve. | ||
| Line 99: | Line 99: | ||
*[[PSAP]] -ve.<ref name=pmid7512941/> | *[[PSAP]] -ve.<ref name=pmid7512941/> | ||
*CD34 -ve.<ref name=pmid9665475>{{Cite journal | last1 = Aldenborg | first1 = F. | last2 = Peeker | first2 = R. | last3 = Fall | first3 = M. | last4 = Olofsson | first4 = A. | last5 = Enerbäck | first5 = L. | title = Metaplastic transformation of urinary bladder epithelium: effect on mast cell recruitment, distribution, and phenotype expression. | journal = Am J Pathol | volume = 153 | issue = 1 | pages = 149-57 | month = Jul | year = 1998 | doi = 10.1016/S0002-9440(10)65555-1 | PMID = 9665475 }}</ref> (???) | *CD34 -ve.<ref name=pmid9665475>{{Cite journal | last1 = Aldenborg | first1 = F. | last2 = Peeker | first2 = R. | last3 = Fall | first3 = M. | last4 = Olofsson | first4 = A. | last5 = Enerbäck | first5 = L. | title = Metaplastic transformation of urinary bladder epithelium: effect on mast cell recruitment, distribution, and phenotype expression. | journal = Am J Pathol | volume = 153 | issue = 1 | pages = 149-57 | month = Jul | year = 1998 | doi = 10.1016/S0002-9440(10)65555-1 | PMID = 9665475 }}</ref> (???) | ||
*p63 -ve (0/32 cases<ref name=pmid23939154>{{Cite journal | last1 = Shen | first1 = Q. | last2 = Sun | first2 = LH. | last3 = Wang | first3 = JH. | last4 = Liu | first4 = LB. | last5 = He | first5 = Q. | last6 = Jin | first6 = J. | title = [Pathological and immunohistochemical analyses of 32 cases of nephrogenic adenoma]. | journal = Beijing Da Xue Xue Bao | volume = 45 | issue = 4 | pages = 522-6 | month = Aug | year = 2013 | doi = | PMID = 23939154 }}</ref> ). | |||
*[[CK20]] -ve usually (6 +ve of 32 cases<ref name=pmid23939154/>). | |||
*[[CK34betaE12]] -ve usually (8+ve of 32 cases<ref name=pmid23939154/>). | |||
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