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Difference between revisions of "Nephrogenic adenoma"
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| Caption = Nephrogenic adenoma. [[H&E stain]]. | | Caption = Nephrogenic adenoma. [[H&E stain]]. | ||
| Synonyms = mesonephric adenoma, nephrogenic metaplasia | | Synonyms = mesonephric adenoma, nephrogenic metaplasia | ||
| Micro = tubular structures with a microcystic appearance lined by | | Micro = classically tubular structures with a microcystic appearance lined by [[hobnail]]ed cells +/-thick eosinophilic basement membrane; may have tubulocystic, polypoid, papillary or fibromyxoid architecture; usually associated with chronic inflammation | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | | LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | ||
| Line 24: | Line 24: | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = occasionally a papillary-like mass ''or'' flat velvety lesion | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| Line 40: | Line 40: | ||
**Also reported in ureter and prostatic urethra. | **Also reported in ureter and prostatic urethra. | ||
*It is thought to result from displacement of renal tubular cells, as this entity in renal transplant recipients is graft derived.<ref>{{Cite journal | last1 = Mazal | first1 = PR. | last2 = Schaufler | first2 = R. | last3 = Altenhuber-Müller | first3 = R. | last4 = Haitel | first4 = A. | last5 = Watschinger | first5 = B. | last6 = Kratzik | first6 = C. | last7 = Krupitza | first7 = G. | last8 = Regele | first8 = H. | last9 = Meisl | first9 = FT. | title = Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients. | journal = N Engl J Med | volume = 347 | issue = 9 | pages = 653-9 | month = Aug | year = 2002 | doi = 10.1056/NEJMoa013413 | PMID = 12200552 }}</ref> | *It is thought to result from displacement of renal tubular cells, as this entity in renal transplant recipients is graft derived.<ref>{{Cite journal | last1 = Mazal | first1 = PR. | last2 = Schaufler | first2 = R. | last3 = Altenhuber-Müller | first3 = R. | last4 = Haitel | first4 = A. | last5 = Watschinger | first5 = B. | last6 = Kratzik | first6 = C. | last7 = Krupitza | first7 = G. | last8 = Regele | first8 = H. | last9 = Meisl | first9 = FT. | title = Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients. | journal = N Engl J Med | volume = 347 | issue = 9 | pages = 653-9 | month = Aug | year = 2002 | doi = 10.1056/NEJMoa013413 | PMID = 12200552 }}</ref> | ||
==Gross== | |||
Features: | |||
*Usually an incidental finding only seen on microscopy. | |||
*May manifest as: | |||
**A papillary-like mass.<ref name=amin2-27>{{Ref Amin|2-27}}</ref> | |||
**A flat velvety lesion with an irregular border.<ref name=amin2-27>{{Ref Amin|2-27}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | ||
*Tubular structures - | *Tubular structures - the classic morphology. † | ||
** | **Lined by a single cell layer - classically [[hobnail]]ed. ‡ | ||
**+/-Thick eosinophilic basement membrane. | **+/-Thick eosinophilic basement membrane. | ||
** | **Typically microcystic appearance. | ||
*Usually associated with chronic inflammation. | *Usually associated with chronic inflammation. | ||
| Line 53: | Line 60: | ||
*† May be tubulocystic, polypoid, papillary or fibromyxoid.<ref name=pmid23328975>{{Cite journal | last1 = Piña-Oviedo | first1 = S. | last2 = Shen | first2 = SS. | last3 = Truong | first3 = LD. | last4 = Ayala | first4 = AG. | last5 = Ro | first5 = JY. | title = Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry. | journal = Mod Pathol | volume = 26 | issue = 6 | pages = 792-8 | month = Jun | year = 2013 | doi = 10.1038/modpathol.2012.239 | PMID = 23328975 }}</ref> | *† May be tubulocystic, polypoid, papillary or fibromyxoid.<ref name=pmid23328975>{{Cite journal | last1 = Piña-Oviedo | first1 = S. | last2 = Shen | first2 = SS. | last3 = Truong | first3 = LD. | last4 = Ayala | first4 = AG. | last5 = Ro | first5 = JY. | title = Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry. | journal = Mod Pathol | volume = 26 | issue = 6 | pages = 792-8 | month = Jun | year = 2013 | doi = 10.1038/modpathol.2012.239 | PMID = 23328975 }}</ref> | ||
*‡ May be flat.<ref name=pmid23328975/> | *‡ May be flat.<ref name=pmid23328975/> | ||
*Should not have [[necrosis]] or mitoses. | |||
DDx: | DDx: | ||
*[[Urothelial carcinoma]], microcystic and nested variants. | *[[Urothelial carcinoma]], microcystic and nested variants. | ||
| Line 76: | Line 85: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid22415059>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Levea | first2 = CM. | title = Nephrogenic Adenoma of the Urinary Tract: A Review. | journal = Int J Surg Pathol | volume = | issue = | pages = | month = Mar | year = 2012 | doi = 10.1177/1066896912439095 | PMID = 22415059 }}</ref> | Features:<ref name=pmid22415059>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Levea | first2 = CM. | title = Nephrogenic Adenoma of the Urinary Tract: A Review. | journal = Int J Surg Pathol | volume = | issue = | pages = | month = Mar | year = 2012 | doi = 10.1177/1066896912439095 | PMID = 22415059 }}</ref> | ||
*CK7 +ve. | *[[CK7]] +ve. | ||
*PAX2 +ve.<ref name=pmid16400326>{{Cite journal | last1 = Tong | first1 = GX. | last2 = Melamed | first2 = J. | last3 = Mansukhani | first3 = M. | last4 = Memeo | first4 = L. | last5 = Hernandez | first5 = O. | last6 = Deng | first6 = FM. | last7 = Chiriboga | first7 = L. | last8 = Waisman | first8 = J. | title = PAX2: a reliable marker for nephrogenic adenoma. | journal = Mod Pathol | volume = 19 | issue = 3 | pages = 356-63 | month = Mar | year = 2006 | doi = 10.1038/modpathol.3800535 | PMID = 16400326 }}</ref> | *PAX2 +ve.<ref name=pmid16400326>{{Cite journal | last1 = Tong | first1 = GX. | last2 = Melamed | first2 = J. | last3 = Mansukhani | first3 = M. | last4 = Memeo | first4 = L. | last5 = Hernandez | first5 = O. | last6 = Deng | first6 = FM. | last7 = Chiriboga | first7 = L. | last8 = Waisman | first8 = J. | title = PAX2: a reliable marker for nephrogenic adenoma. | journal = Mod Pathol | volume = 19 | issue = 3 | pages = 356-63 | month = Mar | year = 2006 | doi = 10.1038/modpathol.3800535 | PMID = 16400326 }}</ref> | ||
*PAX8 +ve. | *[[PAX8]] +ve. | ||
*[[AMACR]] +ve/-ve. | *[[AMACR]] +ve/-ve. | ||
Others:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 }}</ref> | Others:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | ||
*p53 -ve. | *p53 -ve. | ||
*CEA -ve. | *[[CEA]] -ve. | ||
*Ki-67 low (<5%). | *Ki-67 low (<5%). | ||
*[[MUC1]] +ve. | *[[MUC1]] +ve. | ||
**Marks distal renal tubule.<ref name=pmid19730362>{{Cite journal | last1 = Fromont | first1 = G. | last2 = Barcat | first2 = L. | last3 = Gaudin | first3 = J. | last4 = Irani | first4 = J. | title = Revisiting the immunophenotype of nephrogenic adenoma. | journal = Am J Surg Pathol | volume = 33 | issue = 11 | pages = 1654-8 | month = Nov | year = 2009 | doi = 10.1097/PAS.0b013e3181b40061 | PMID = 19730362 }}</ref> | **Marks distal renal tubule.<ref name=pmid19730362>{{Cite journal | last1 = Fromont | first1 = G. | last2 = Barcat | first2 = L. | last3 = Gaudin | first3 = J. | last4 = Irani | first4 = J. | title = Revisiting the immunophenotype of nephrogenic adenoma. | journal = Am J Surg Pathol | volume = 33 | issue = 11 | pages = 1654-8 | month = Nov | year = 2009 | doi = 10.1097/PAS.0b013e3181b40061 | PMID = 19730362 }}</ref> | ||
*PSA -ve.<ref name=pmid7512941>{{Cite journal | last1 = Malpica | first1 = A. | last2 = Ro | first2 = JY. | last3 = Troncoso | first3 = P. | last4 = Ordoñez | first4 = NG. | last5 = Amin | first5 = MB. | last6 = Ayala | first6 = AG. | title = Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. | journal = Hum Pathol | volume = 25 | issue = 4 | pages = 390-5 | month = Apr | year = 1994 | doi = | PMID = 7512941 }}</ref> | *PSA -ve.<ref name=pmid7512941>{{Cite journal | last1 = Malpica | first1 = A. | last2 = Ro | first2 = JY. | last3 = Troncoso | first3 = P. | last4 = Ordoñez | first4 = NG. | last5 = Amin | first5 = MB. | last6 = Ayala | first6 = AG. | title = Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. | journal = Hum Pathol | volume = 25 | issue = 4 | pages = 390-5 | month = Apr | year = 1994 | doi = | PMID = 7512941 }}</ref> | ||
*PSAP -ve.<ref name=pmid7512941/> | *[[PSAP]] -ve.<ref name=pmid7512941/> | ||
*CD34 -ve.<ref name=pmid9665475>{{Cite journal | last1 = Aldenborg | first1 = F. | last2 = Peeker | first2 = R. | last3 = Fall | first3 = M. | last4 = Olofsson | first4 = A. | last5 = Enerbäck | first5 = L. | title = Metaplastic transformation of urinary bladder epithelium: effect on mast cell recruitment, distribution, and phenotype expression. | journal = Am J Pathol | volume = 153 | issue = 1 | pages = 149-57 | month = Jul | year = 1998 | doi = 10.1016/S0002-9440(10)65555-1 | PMID = 9665475 }}</ref> (???) | *CD34 -ve.<ref name=pmid9665475>{{Cite journal | last1 = Aldenborg | first1 = F. | last2 = Peeker | first2 = R. | last3 = Fall | first3 = M. | last4 = Olofsson | first4 = A. | last5 = Enerbäck | first5 = L. | title = Metaplastic transformation of urinary bladder epithelium: effect on mast cell recruitment, distribution, and phenotype expression. | journal = Am J Pathol | volume = 153 | issue = 1 | pages = 149-57 | month = Jul | year = 1998 | doi = 10.1016/S0002-9440(10)65555-1 | PMID = 9665475 }}</ref> (???) | ||
*p63 -ve (0/32 cases<ref name=pmid23939154>{{Cite journal | last1 = Shen | first1 = Q. | last2 = Sun | first2 = LH. | last3 = Wang | first3 = JH. | last4 = Liu | first4 = LB. | last5 = He | first5 = Q. | last6 = Jin | first6 = J. | title = [Pathological and immunohistochemical analyses of 32 cases of nephrogenic adenoma]. | journal = Beijing Da Xue Xue Bao | volume = 45 | issue = 4 | pages = 522-6 | month = Aug | year = 2013 | doi = | PMID = 23939154 }}</ref> ). | |||
*[[CK20]] -ve usually (6 +ve of 32 cases<ref name=pmid23939154/>). | |||
*[[CK34betaE12]] -ve usually (8+ve of 32 cases<ref name=pmid23939154/>). | |||
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