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Difference between revisions of "Nephrogenic adenoma"
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| Caption = Nephrogenic adenoma. [[H&E stain]]. | | Caption = Nephrogenic adenoma. [[H&E stain]]. | ||
| Synonyms = mesonephric adenoma, nephrogenic metaplasia | | Synonyms = mesonephric adenoma, nephrogenic metaplasia | ||
| Micro = tubular structures with a microcystic appearance lined by | | Micro = tubular structures with a microcystic appearance lined by [[hobnail]]ed cells +/-thick eosinophilic basement membrane, usually associated with chronic inflammation | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | | LMDDx = [[urothelial carcinoma]] microcystic and nested variants, [[prostatic adenocarcinoma]], [[clear cell adenocarcinoma]] ([[clear cell adenocarcinoma of the urethra]], [[clear cell carcinoma of the urinary bladder]], metastatic clear cell adenocarcinoma) | ||
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Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | Features:<ref name=pmid12118115>{{Cite journal | last1 = Gokaslan | first1 = ST. | last2 = Krueger | first2 = JE. | last3 = Albores-Saavedra | first3 = J. | title = Symptomatic nephrogenic metaplasia of ureter: a morphologic and immunohistochemical study of four cases. | journal = Mod Pathol | volume = 15 | issue = 7 | pages = 765-70 | month = Jul | year = 2002 | doi = 10.1097/01.MP.0000019578.51568.24 | PMID = 12118115 | url = http://www.nature.com/modpathol/journal/v15/n7/full/3880603a.html }}</ref> | ||
*Tubular structures - '''key feature'''. † | *Tubular structures - '''key feature'''. † | ||
**Lined by a single cell layer - classically | **Lined by a single cell layer - classically [[hobnail]]ed. ‡ | ||
**+/-Thick eosinophilic basement membrane. | **+/-Thick eosinophilic basement membrane. | ||
**Typically microcystic appearance. | **Typically microcystic appearance. | ||