Difference between revisions of "Napsin A"

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'''Napsin''' is a commonly used [[immunostain]] in [[pulmonary pathology]].
'''Napsin A''', also '''napsin''', is a commonly used [[immunostain]] in [[pulmonary pathology]].


==Positive==
==Positive==
*[[Lung adenocarcinoma]] - 83% of cases.<ref name=pmid19740516>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Sharma | first2 = R. | last3 = Illei | first3 = PB. | title = Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. | journal = Hum Pathol | volume = 41 | issue = 1 | pages = 20-5 | month = Jan | year = 2010 | doi = 10.1016/j.humpath.2009.06.014 | PMID = 19740516 }}</ref>
*[[Lung adenocarcinoma]] - 83% of cases.<ref name=pmid19740516>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Sharma | first2 = R. | last3 = Illei | first3 = PB. | title = Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. | journal = Hum Pathol | volume = 41 | issue = 1 | pages = 20-5 | month = Jan | year = 2010 | doi = 10.1016/j.humpath.2009.06.014 | PMID = 19740516 }}</ref>
*[[Papillary renal cell carcinoma]] 79% of cases.<ref name=pmid19740516/>
*[[Papillary renal cell carcinoma]] 79% of cases.<ref name=pmid19740516/>
 
*[[Renal oncocytoma]] 57% of cases.<ref name=pmid25889632>{{Cite journal  | last1 = Zhu | first1 = B. | last2 = Rohan | first2 = SM. | last3 = Lin | first3 = X. | title = Immunoexpression of napsin A in renal neoplasms. | journal = Diagn Pathol | volume = 10 | issue =  | pages = 4 | month = Mar | year = 2015 | doi = 10.1186/s13000-015-0242-z | PMID = 25889632 }}</ref>
===Occasionally positive===
===Occasionally positive===
*[[Clear cell renal cell carcinoma]] - 34% of cases.<ref name=pmid19740516/>
*[[Clear cell renal cell carcinoma]] - 34% of cases.<ref name=pmid19740516/>
*[[Papillary thyroid carcinoma]] - 2/81 cases, tall cell variant only.<ref name=pmid19740516/>
*[[Papillary thyroid carcinoma]] - 2/81 cases, tall cell variant only.<ref name=pmid19740516/>
*[[Clear cell tubulopapillary RCC]] - 47% of cases.<ref name=pmid25889632/>


==Negative==
==Negative==
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*[[Colorectal adenocarcinoma]].<ref name=pmid19740516/>
*[[Colorectal adenocarcinoma]].<ref name=pmid19740516/>
*[[Pancreatic adenocarcinoma]].<ref name=pmid19740516/>
*[[Pancreatic adenocarcinoma]].<ref name=pmid19740516/>
*[[Breast carcinoma]].<ref name=pmid19740516/>
*[[Breast carcinoma]] (0 positive of 17 cases<ref name=pmid19740516/>).
 
<gallery>
File:Adenocarcinoma - Napsin A immunostain (6838767882).jpg | Napsin in pulomonary adenocarcinoma (WC/Yale Rosen)
File:Adenocarcinoma - Napsin A immunostain (5762462036).jpg | Coarse Napsin staining pattern  (WC/Yale Rosen)
</gallery>


==See also==
==See also==

Latest revision as of 14:55, 10 October 2019

Napsin A, also napsin, is a commonly used immunostain in pulmonary pathology.

Positive

Occasionally positive

Negative

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Bishop, JA.; Sharma, R.; Illei, PB. (Jan 2010). "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.". Hum Pathol 41 (1): 20-5. doi:10.1016/j.humpath.2009.06.014. PMID 19740516.
  2. 2.0 2.1 Zhu, B.; Rohan, SM.; Lin, X. (Mar 2015). "Immunoexpression of napsin A in renal neoplasms.". Diagn Pathol 10: 4. doi:10.1186/s13000-015-0242-z. PMID 25889632.