Difference between revisions of "NUT carcinoma"
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*Defined by mutation in ''NUT'' gene. | *Defined by mutation in ''NUT'' gene. | ||
**''NUT'' = ''Nuclear protein in testis''.<ref>{{OMIM|608963}}</ref> | **''NUT'' = ''Nuclear protein in testis''.<ref>{{OMIM|608963}}</ref> | ||
Clinical: | |||
*Usually midline - as the name of the tumour suggests. | |||
==Microscopic== | ==Microscopic== | ||
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</ref> | </ref> | ||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
*Islands of well-differentiated squamous epithelium - '''key feature'''. | |||
==Molecular== | ==Molecular== | ||
Revision as of 19:49, 15 November 2011
NUT midline carcinoma is a super rare tumour.
General
- Not specific to any tissue type or organ.[1]
- Defined by mutation in NUT gene.
- NUT = Nuclear protein in testis.[2]
Clinical:
- Usually midline - as the name of the tumour suggests.
Microscopic
Features:[1]
- Poorly differentiated carcinoma.
- Islands of well-differentiated squamous epithelium - key feature.
Molecular
References
- ↑ 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749