48,466
edits
Difference between revisions of "NUT carcinoma"
Jump to navigation
Jump to search
tweak
(→IHC) |
(tweak) |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 7: | Line 7: | ||
| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium | | Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma | | LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma, | ||
| Stains = | | Stains = | ||
| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve | | IHC = p63 +ve, CD34 +ve/-ve, EMA +ve, NUT +ve | ||
| EM = | | EM = | ||
| Molecular = t(15;19) | | Molecular = t(15;19) | ||
| Line 29: | Line 29: | ||
| ClinDDx = | | ClinDDx = | ||
}} | }} | ||
'''NUT carcinoma''' is a rare tumour of the [[head and neck pathology|head and neck]]. The [[World Health Organization|WHO]] calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP|145}}</ref> It is also known as '''NUT midline carcinoma''', abbreviated '''NMC'''. | '''NUT carcinoma''' is a rare malignant tumour classically of the [[head and neck pathology|head and neck]]. The [[World Health Organization|WHO]] calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP|145}}</ref> It is also known as '''NUT midline carcinoma''', abbreviated '''NMC'''. | ||
==General== | ==General== | ||
| Line 50: | Line 50: | ||
DDx: | DDx: | ||
*[[Squamous cell carcinoma]]. | |||
*[[Carcinoma ex pleomorphic adenoma]]. | *[[Carcinoma ex pleomorphic adenoma]]. | ||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
*SMARCB1-deficient sinonasal carcinoma.<ref name=pmid25007146>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Antonescu | first2 = CR. | last3 = Westra | first3 = WH. | title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 38 | issue = 9 | pages = 1282-9 | month = Sep | year = 2014 | doi = 10.1097/PAS.0000000000000285 | PMID = 25007146 }}</ref> | *[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Antonescu | first2 = CR. | last3 = Westra | first3 = WH. | title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 38 | issue = 9 | pages = 1282-9 | month = Sep | year = 2014 | doi = 10.1097/PAS.0000000000000285 | PMID = 25007146 }}</ref> | ||
*Acute leukemia - especially as ''NUT | *Acute leukemia - especially as ''NUT carcinoma'' may be CD34 positive.<ref name=pmid>{{Cite journal | last1 = Li | first1 = W. | last2 = Chastain | first2 = K. | title = NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. | journal = Blood | volume = 132 | issue = 4 | pages = 456 | month = Jul | year = 2018 | doi = 10.1182/blood-2017-07-796268 | PMID = 30049733 }}</ref> | ||
===Images=== | ===Images=== | ||
| Line 67: | Line 68: | ||
==IHC== | ==IHC== | ||
*NUT +ve ('''key immunostain'''). | |||
*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal | last1 = Stelow | first1 = EB. | title = A review of NUT midline carcinoma. | journal = Head Neck Pathol | volume = 5 | issue = 1 | pages = 31-5 | month = Mar | year = 2011 | doi = 10.1007/s12105-010-0235-x | PMID = 21221870 }}</ref> | *CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal | last1 = Stelow | first1 = EB. | title = A review of NUT midline carcinoma. | journal = Head Neck Pathol | volume = 5 | issue = 1 | pages = 31-5 | month = Mar | year = 2011 | doi = 10.1007/s12105-010-0235-x | PMID = 21221870 }}</ref> | ||
*p63 +ve.<ref name=pmid22534723>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Westra | first2 = WH. | title = NUT midline carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 36 | issue = 8 | pages = 1216-21 | month = Aug | year = 2012 | doi = 10.1097/PAS.0b013e318254ce54 | PMID = 22534723 }}</ref> | *p63 +ve.<ref name=pmid22534723>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Westra | first2 = WH. | title = NUT midline carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 36 | issue = 8 | pages = 1216-21 | month = Aug | year = 2012 | doi = 10.1097/PAS.0b013e318254ce54 | PMID = 22534723 }}</ref> | ||