Difference between revisions of "Multiple sclerosis"

From Libre Pathology
Jump to navigation Jump to search
(redirect for now)
 
(→‎Microscopic: +images)
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
#redirect [[Neuropathology#Multiple_sclerosis]]
'''Multiple sclerosis''', abbreviated '''MS''', is a chronic inflammatory condition of the central nervous system.
 
==General==
*A bread 'n butter disease of neurology in Canada.
 
Clinical:
*CSF: oligoclonal bands of immunoglobulin.<ref>{{Ref PBoD8|1311}}</ref>
 
Classification of MS lesions:
*Early active.
*Inactive.
*Early remyelinating.
*Late remyelinating.
 
==Radiologic/Gross==
Features:<ref>URL: [http://library.med.utah.edu/kw/ms/path.html http://library.med.utah.edu/kw/ms/path.html]. Accessed on: 12 July 2010.</ref>
*White matter lesions.
**Cerebrum (classically): periventricular distribution.
**Optic nerves (optic neuritis) - classic presentation.
 
==Microscopic==
Features:<ref>URL: [http://library.med.utah.edu/kw/ms/path.html http://library.med.utah.edu/kw/ms/path.html]. Accessed on: 12 July 2010.</ref>
*Perivascular inflammation.
**Esp. lymphocytes.
*Demyelination.
**Subcortical myelinated fibers are often spared.
 
Chronic lesions - specific features:<ref>{{Ref APBR|425 Q43}}</ref>
#Macrophages.
#Astrocyte enlargement.
 
DDx:
*[[ADEM]].
*[[Neuromyelitis optica]].
*[[Lymphoma]].
*[[Diffuse astrocytoma]].
 
===Images===
<gallery>
Image: MS_Demyelinisation_CD68_10xv2.jpg | Demyelination in MS - CD68 stain. (WC/Marvin 101)
Image: MS Demyelinisation KB 10x.jpg | Demyelination in MS - KB stain. (WC/Marvin 101)
</gallery>
www:
*[http://path.upmc.edu/cases/case79.html Multiple sclerosis masquerading as a diffuse astrocytoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case636.html Tumefactive multiple sclerosis - several images (upmc.edu)].
 
==IHC==
*HAM-56 - macrophages.
*CD8 - lymphocytes.
 
==See also==
*[[Neuropathology]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Neuropathology]]

Latest revision as of 06:34, 15 November 2014

Multiple sclerosis, abbreviated MS, is a chronic inflammatory condition of the central nervous system.

General

  • A bread 'n butter disease of neurology in Canada.

Clinical:

  • CSF: oligoclonal bands of immunoglobulin.[1]

Classification of MS lesions:

  • Early active.
  • Inactive.
  • Early remyelinating.
  • Late remyelinating.

Radiologic/Gross

Features:[2]

  • White matter lesions.
    • Cerebrum (classically): periventricular distribution.
    • Optic nerves (optic neuritis) - classic presentation.

Microscopic

Features:[3]

  • Perivascular inflammation.
    • Esp. lymphocytes.
  • Demyelination.
    • Subcortical myelinated fibers are often spared.

Chronic lesions - specific features:[4]

  1. Macrophages.
  2. Astrocyte enlargement.

DDx:

Images

  • Demyelination in MS - CD68 stain. (WC/Marvin 101)

  • Demyelination in MS - KB stain. (WC/Marvin 101)

www:

IHC

  • HAM-56 - macrophages.
  • CD8 - lymphocytes.

See also

References

  1. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1311. ISBN 978-1416031215.
  2. ↑ URL: http://library.med.utah.edu/kw/ms/path.html. Accessed on: 12 July 2010.
  3. ↑ URL: http://library.med.utah.edu/kw/ms/path.html. Accessed on: 12 July 2010.
  4. ↑ Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 425 Q43. ISBN 978-1416025887.
Retrieved from "https://librepathology.org/w/index.php?title=Multiple_sclerosis&oldid=34937"