Difference between revisions of "Multiple endocrine neoplasia"

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==Simple==
==Simple==
===MEN I===
===MEN 1===
* Parathyroid adenoma.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 2 September 2010.</ref>
* Parathyroid adenoma.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2]. Accessed on: 2 September 2010.</ref>
* [[Pancreas|Pancreatic]] neuroendocrine tumours.
* [[Pancreas|Pancreatic]] neuroendocrine tumours.
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Memory device: '''3 Ps'''.
Memory device: '''3 Ps'''.


===MEN IIa/IIb (II/III)===
===MEN 2a/2b (II/III)===
* Parathyroid adenoma.
* Parathyroid adenoma.
* [[Medullary thyroid carcinoma]].
* [[Medullary thyroid carcinoma]] (usu. preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>).
* Pheochromocytoma.  
* [[Pheochromocytoma]].  


Notes:
Notes:
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==Details==
==Details==
===MEN IIa===
===MEN 2a===
*Ganglioneuromatosis of the alimentary tract.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/162300 http://www.ncbi.nlm.nih.gov/omim/162300]. Accessed on: 19 November 2010.</ref><ref name=pmid17306015>{{cite journal |author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' |title=Multiple rectal carcinoids with diffuse ganglioneuromatosis |journal=World J Surg Oncol |volume=5 |issue= |pages=19 |year=2007 |pmid=17306015 |pmc=1805501 |doi=10.1186/1477-7819-5-19 |url=}}</ref>
*Ganglioneuromatosis of the alimentary tract.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/162300 http://www.ncbi.nlm.nih.gov/omim/162300]. Accessed on: 19 November 2010.</ref><ref name=pmid17306015>{{cite journal |author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' |title=Multiple rectal carcinoids with diffuse ganglioneuromatosis |journal=World J Surg Oncol |volume=5 |issue= |pages=19 |year=2007 |pmid=17306015 |pmc=1805501 |doi=10.1186/1477-7819-5-19 |url=}}</ref>
**Extra large nerves in GI tract.
**Extra large nerves in GI tract.
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Images:  
Images:  
*[http://wjso.com/content/5/1/19/figure/F3 Ganglioneuromatosis - crappy quality (wjso.com)].
*[http://wjso.com/content/5/1/19/figure/F3 Ganglioneuromatosis - crappy quality (wjso.com)].
===MEN 2b===
*Has a [[Marfan syndrome|marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8|1160}}}}</ref>


==References==
==References==

Revision as of 21:03, 19 March 2011

Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN 1

Memory device: 3 Ps.

MEN 2a/2b (II/III)

Notes:

  • BOTH have parathyroid adenoma.
  • EACH has one below and one above the diaphragm.

Details

MEN 2a

  • Ganglioneuromatosis of the alimentary tract.[3][4]
    • Extra large nerves in GI tract.

Images:

MEN 2b

References

  1. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 2 September 2010.
  2. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1162. ISBN 978-1416031215. }}
  3. URL: http://www.ncbi.nlm.nih.gov/omim/162300. Accessed on: 19 November 2010.
  4. Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.
  5. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1160. ISBN 978-1416031215. }}