Multilocular cystic renal neoplasm of low malignant potential

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Multilocular cystic renal cell carcinoma, abbreviated MCRCC, is a rare kidney tumour.

It is also known as multilocular clear cell renal cell carcinoma.[1]

As the behaviour of the tumour is very good, it has be proposed that this entity be renamed multilocular cystic renal cell neoplasms of low malignant potential.[2]

General

  • No recurrences or metastasis in the literature.[3]
  • Case report rare.[4]

Gross

Features:[3]

  • Cystic with thin septa.
  • Well circumscribed.

Note:

  • This tumour, radiologically, can often be separated from other cystic tumours.[5]

Microscopic

Features:[3]

  • Polygonal cells within the septa.
  • Clear cytoplasm.
  • +/-Calcification (common).

DDx:

IHC

  • EMA +ve.
  • Keratins +ve.
  • CD68 -ve.

See also

References

  1. ↑ Chowdhury, AR.; Chakraborty, D.; Bhattacharya, P.; Dey, RK. (Apr 2013). "Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman.". Urol Ann 5 (2): 119-21. doi:10.4103/0974-7796.110012. PMID 23798872.
  2. ↑ Montironi, R.; Mazzucchelli, R.; Scarpelli, M.; Lopez-Beltran, A.; Cheng, L. (Dec 2013). "Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma.". Histol Histopathol 28 (12): 1555-66. PMID 23893851.
  3. ↑ 3.0 3.1 3.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.
  4. ↑ Agarwal, S.; Agrawal, U.; Mohanty, NK.; Saxena, S. (Mar 2011). "Multilocular cystic renal cell carcinoma: a case report of a rare entity.". Arch Pathol Lab Med 135 (3): 290-2. doi:10.1043/2010-0243-LE.1. PMID 21366448.
  5. ↑ You, D.; Shim, M.; Jeong, IG.; Song, C.; Kim, JK.; Ro, JY.; Hong, JH.; Ahn, H. et al. (Jul 2011). "Multilocular cystic renal cell carcinoma: clinicopathological features and preoperative prediction using multiphase computed tomography.". BJU Int. doi:10.1111/j.1464-410X.2011.10247.x. PMID 21722289.
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