Difference between revisions of "Mucinous cystadenoma of the ovary"

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Line 11: Line 11:
| IHC        =
| IHC        =
| EM        =
| EM        =
| Molecular  =
| Molecular  = +/-[[KRAS mutation]]
| IF        =
| IF        =
| Gross      = multiloculated cystic lesion, thin cyst walls/no solid areas
| Gross      = multiloculated cystic lesion, thin cyst walls/no solid areas
Line 27: Line 27:
| Prognosis  = benign
| Prognosis  = benign
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    = other [[ovarian tumours]] - esp. mucinous ones, and mucinous appendiceal lesions
| Tx        = cystectomy/oophorectomy
| Tx        = cystectomy/oophorectomy
}}
}}
Line 36: Line 36:
==General==
==General==
*Common.<ref name=pmid22246404>{{Cite journal  | last1 = Pongsuvareeyakul | first1 = T. | last2 = Khunamornpong | first2 = S. | last3 = Settakorn | first3 = J. | last4 = Sukpan | first4 = K. | last5 = Suprasert | first5 = P. | last6 = Siriaunkgul | first6 = S. | title = Accuracy of frozen-section diagnosis of ovarian mucinous tumors. | journal = Int J Gynecol Cancer | volume = 22 | issue = 3 | pages = 400-6 | month = Mar | year = 2012 | doi = 10.1097/IGC.0b013e31823dc328 | PMID = 22246404 }}</ref>
*Common.<ref name=pmid22246404>{{Cite journal  | last1 = Pongsuvareeyakul | first1 = T. | last2 = Khunamornpong | first2 = S. | last3 = Settakorn | first3 = J. | last4 = Sukpan | first4 = K. | last5 = Suprasert | first5 = P. | last6 = Siriaunkgul | first6 = S. | title = Accuracy of frozen-section diagnosis of ovarian mucinous tumors. | journal = Int J Gynecol Cancer | volume = 22 | issue = 3 | pages = 400-6 | month = Mar | year = 2012 | doi = 10.1097/IGC.0b013e31823dc328 | PMID = 22246404 }}</ref>
**Approximately 80% of all mucinous ovarian tumours.<ref name=pmid15626914>{{cite journal |author=Hart WR |title=Mucinous tumors of the ovary: a review |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=1 |pages=4–25 |year=2005 |month=January |pmid=15626914 |doi= |url=}}</ref>
*Benign.
*Benign.


Line 42: Line 43:
*May be very large large.<ref name=pmid22283565>{{Cite journal  | last1 = Leys | first1 = CM. | last2 = Gasior | first2 = AC. | last3 = Hornberger | first3 = LL. | last4 = St Peter | first4 = SD. | title = Laparoscopic resection of massive ovarian mucinous cystadenoma. | journal = J Laparoendosc Adv Surg Tech A | volume = 22 | issue = 3 | pages = 307-10 | month = Apr | year = 2012 | doi = 10.1089/lap.2011.0435 | PMID = 22283565 }}</ref>
*May be very large large.<ref name=pmid22283565>{{Cite journal  | last1 = Leys | first1 = CM. | last2 = Gasior | first2 = AC. | last3 = Hornberger | first3 = LL. | last4 = St Peter | first4 = SD. | title = Laparoscopic resection of massive ovarian mucinous cystadenoma. | journal = J Laparoendosc Adv Surg Tech A | volume = 22 | issue = 3 | pages = 307-10 | month = Apr | year = 2012 | doi = 10.1089/lap.2011.0435 | PMID = 22283565 }}</ref>
*No solid areas/thin cyst walls.
*No solid areas/thin cyst walls.
===Images===
<gallery>
Image:Mucinous Cystadenoma of Ovary (218889489).jpg | Mucinous cystadenoma of the ovary. (WC)
</gallery>


==Microscopic==
==Microscopic==
Line 47: Line 53:
*Cysts lined by a simple mucinous epithelium.
*Cysts lined by a simple mucinous epithelium.
*No cytologic atypia.
*No cytologic atypia.
Note:
*A borderline component may be present but ''must be <10%'' of the tumour.<ref name=Ref_GP>{{Ref GP|416}}</ref>
**Lesions with <10% borderline component are known as ''mucinous cystadenoma of the ovary with focal proliferation'' or ''mucinous cystadenoma of the ovary with focal atypia''.


DDx:
DDx:
Line 65: Line 75:
Image: Ovarian mucinous cystadenoma - a3- very high mag.jpg | OMC - very high mag.
Image: Ovarian mucinous cystadenoma - a3- very high mag.jpg | OMC - very high mag.
</gallery>
</gallery>
==Molecular==
*[[KRAS mutation]]s common ~ 56% of mucinous cystadenomas in one series.<ref name=pmid9118042>{{Cite journal  | last1 = Cuatrecasas | first1 = M. | last2 = Villanueva | first2 = A. | last3 = Matias-Guiu | first3 = X. | last4 = Prat | first4 = J. | title = K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. | journal = Cancer | volume = 79 | issue = 8 | pages = 1581-6 | month = Apr | year = 1997 | doi =  | PMID = 9118042 }}</ref>
==Sign out==
<pre>
Left Ovarian Cyst, Excision:
- Mucinous cystadenoma.
</pre>
===Mucinous cystadenoma with focal proliferation===
<pre>
Left Ovarian Cyst, Excision:
- Mucinous cystadenoma with focal proliferation, see comment.
Comment:
The proliferative component is less than 10% of the lesion.
</pre>


==See also==
==See also==
*[[Ovarian tumours]].
*[[Ovarian tumours]].
*[[Mucinous ovarian tumours]].
*[[Mucinous cystadenoma]].
*[[Mucinous cystadenoma]].
*[[Mucinous cystadenoma of the appendix]].
*[[Mucinous cystadenoma of the appendix]].

Latest revision as of 16:36, 1 March 2018

Mucinous cystadenoma of the ovary
Diagnosis in short

Ovarian mucinous cystadenoma. H&E stain.
LM cysts lined by a simple mucinous epithelium, no cytologic atypia
LM DDx seromucinous borderline tumour of the ovary, mucinous borderline tumour of the ovary
Molecular +/-KRAS mutation
Gross multiloculated cystic lesion, thin cyst walls/no solid areas
Site ovary - see ovarian tumours
Prevalence common
Prognosis benign
Clin. DDx other ovarian tumours - esp. mucinous ones, and mucinous appendiceal lesions
Treatment cystectomy/oophorectomy

Mucinous cystadenoma of the ovary, also ovarian mucinous cystadenoma, is a common benign ovarian tumour.

It is unrelated to mucinous cystadenoma of the appendix.

General

  • Common.[1]
    • Approximately 80% of all mucinous ovarian tumours.[2]
  • Benign.

Gross

  • Usually multiloculated.
  • May be very large large.[3]
  • No solid areas/thin cyst walls.

Images

  • Mucinous cystadenoma of the ovary. (WC)

Microscopic

Features:

  • Cysts lined by a simple mucinous epithelium.
  • No cytologic atypia.

Note:

  • A borderline component may be present but must be <10% of the tumour.[4]
    • Lesions with <10% borderline component are known as mucinous cystadenoma of the ovary with focal proliferation or mucinous cystadenoma of the ovary with focal atypia.

DDx:

Images

  • OMC - low mag.

  • OMC - low mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - high mag.

  • OMC - very high mag.

Molecular

Sign out

Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma.

Mucinous cystadenoma with focal proliferation

Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma with focal proliferation, see comment.

Comment:
The proliferative component is less than 10% of the lesion.

See also

References

  1. ↑ Pongsuvareeyakul, T.; Khunamornpong, S.; Settakorn, J.; Sukpan, K.; Suprasert, P.; Siriaunkgul, S. (Mar 2012). "Accuracy of frozen-section diagnosis of ovarian mucinous tumors.". Int J Gynecol Cancer 22 (3): 400-6. doi:10.1097/IGC.0b013e31823dc328. PMID 22246404.
  2. ↑ Hart WR (January 2005). "Mucinous tumors of the ovary: a review". Int. J. Gynecol. Pathol. 24 (1): 4–25. PMID 15626914.
  3. ↑ Leys, CM.; Gasior, AC.; Hornberger, LL.; St Peter, SD. (Apr 2012). "Laparoscopic resection of massive ovarian mucinous cystadenoma.". J Laparoendosc Adv Surg Tech A 22 (3): 307-10. doi:10.1089/lap.2011.0435. PMID 22283565.
  4. ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 416. ISBN 978-0443069208.
  5. ↑ Cuatrecasas, M.; Villanueva, A.; Matias-Guiu, X.; Prat, J. (Apr 1997). "K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.". Cancer 79 (8): 1581-6. PMID 9118042.

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