Mucinous adenocarcinoma of the prostate

From Libre Pathology
Revision as of 05:31, 11 June 2016 by Michael (talk | contribs) (split out)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Mucinous adenocarcinoma of the prostate is an uncommon type of prostate cancer.

General

  • Rare.
  • Most often Gleason 3+4 ~ 80% in one series of 47 cases.[1]

Gleason pattern:

  • In the past, it has been suggested that the mucinous component be assigned Gleason pattern 4.[2]
  • The prognosis is similar or may be better than the conventional type of prostate cancer in a large series;[1] thus, it seems reasonable to grade based on the pattern (as advocated by some experts[3]).

Microscopic

Features:

  • Cytologically malignant cells floating in mucin.
  • > 25% of tumour mucinous.[2]
    • Two studies suggests >= 25%.[4][5]

Notes:

DDx:

See also

References

  1. 1.0 1.1 Osunkoya, AO.; Nielsen, ME.; Epstein, JI. (Mar 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.". Am J Surg Pathol 32 (3): 468-72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
  2. 2.0 2.1 Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
  3. Osunkoya, AO.; Adsay, NV.; Cohen, C.; Epstein, JI.; Smith, SL. (Jul 2008). "MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomy.". Mod Pathol 21 (7): 789-94. doi:10.1038/modpathol.2008.47. PMID 18487999.
  4. Osunkoya AO, Nielsen ME, Epstein JI (March 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases". Am. J. Surg. Pathol. 32 (3): 468–72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
  5. 5.0 5.1 Bohman, KD.; Osunkoya, AO. (Nov 2012). "Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.". Adv Anat Pathol 19 (6): 374-87. doi:10.1097/PAP.0b013e318271a361. PMID 23060063.