Difference between revisions of "Molecular pathology"

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Molecular pathology (view source)

Revision as of 16:13, 3 May 2011

2,026 bytes removed ,  16:13, 3 May 2011
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===Tests===
===Tests===
====Hereditary====
A list of tests are found in the ''[[Molecular pathology tests]]'' article.
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Technique
! Disease
! Notes
|-
| F2<ref>{{OMIM|176930}}</ref>
| PCR
| thrombophilia
| see ''[[Pulmonary_embolism#Risks_factors_.28VTE.29|Risks for VTE]]''
|-
| F5<ref>{{OMIM|612309}}</ref>
| PCR
| thrombophilia
| see ''[[Pulmonary_embolism#Risks_factors_.28VTE.29|Risks for VTE]]''
|-
| HFE<ref>{{OMIM|613609}}</ref> Cys282Tyr, His63Asp
| PCR
| [[hemochromatosis]]
| -
|-
| RYR1
| PCR & sequencing
| malignant hyperthermia
| anesthetics
|-
| several
| PCR & sequencing
| herediary [[amyloidosis]]
|
|-
| HBA
| PCR
| Alpha thalassemia
|
|}
 
====[[Lymphoma]]====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Technique
! Disease
! Notes
|-
| BCL2
| PCR
| follicular lymphoma vs. follicular hyperplasia
|
|-
| several
| Southern / PCR
| T cell neoplasia
|
|-
| Ig heavy chain, Ig light chain
| Southern / PCR
| B cell neoplasia
|
|-
| EBV
|
| PTLPD vs. rejection
|
|-
| HHV8
| PCR, HPV linear array
| HHV8 associated lymphomas (body cavity lymphoma, primary effusion lymphoma)
|
|}
 
====Leukemia====
*Several.
 
====Carcinoma====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Technique
! Disease
! Notes
|-
| EBV quantitation
| PQ-PCR
| [[Nasopharyngeal carcinoma]]
|
|-
| HPV several
| PCR
| squamous cell carcinoma ([[cervix]])
|
|-
| KRAS, BRAF
| fluorescent RFLP, real time PCR, sequencing
| netastatic [[colorectal carinoma]]
|
|-
| EGRF
| fluorescent RFLP
| non small cell [[lung cancer]]
|
|-
| BRAF V600E
| ARMS
| [[papillary thyroid carcinoma]]
|
|}
 
====Other====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
! Target
! Technique
! Disease
! Notes
|-
| LOH 1p, 19q
| PCR
| [[oligodendroglioma]]
|
|-
|
| 15 STRs and amelogenin (XY) loci
| identity testing
|
|-
| KIT, BRAF
| sequencying, ARMS
| [[malignant melanoma]]
|
|-
| several
| PQ-PCR
| [[synovial sarcoma]]
|
|-
| JAK2 V617F
| ARMS
| myeloproliferative disorders
|
|-
| KIT
| sequencing
| AML, mastocytosis, [[GIST]]
|
|}


==Cytogenetics==
==Cytogenetics==
Michael
48,453

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