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Difference between revisions of "Mixed germ cell tumour"
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| IF = | | IF = | ||
| Gross = heterogeneous appearance, typically solid and cystic | | Gross = heterogeneous appearance, typically solid and cystic | ||
| Grossing = [[ | | Grossing = [[orchiectomy grossing]] | ||
| Staging = [[ | | Staging = [[testicular cancer staging]] | ||
| Site = [[ovary]], [[testis]], [[mediastinum]], other | | Site = [[ovary]], [[testis]], [[mediastinum]], other | ||
| Assdx = | | Assdx = | ||
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==IHC== | ==IHC== | ||
*Immunostains are useful for differentiating components, e.g. yolk sac tumour versus [[embryonal carcinoma]]. | *Immunostains are useful for differentiating components, e.g. [[yolk sac tumour]] versus [[embryonal carcinoma]]. | ||
Looking for elements | Looking for elements | ||
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*OCT4 +ve -- [[seminoma]]. | *OCT4 +ve -- [[seminoma]]. | ||
*D2-40 +ve -- seminoma, useful for [[LVI]]. | *D2-40 +ve -- seminoma, useful for [[LVI]]. | ||
*Pankeratin +ve -- embryonal carcinoma. | *[[Pankeratin]] +ve -- embryonal carcinoma. | ||
*CEA-M. | *CEA-M. | ||
*[[EMA]] +ve -- metastatic carcinoma.<ref>{{Cite journal | last1 = Shek | first1 = TW. | last2 = Yuen | first2 = ST. | last3 = Luk | first3 = IS. | last4 = Wong | first4 = MP. | title = Germ cell tumour as a diagnostic pitfall of metastatic carcinoma. | journal = J Clin Pathol | volume = 49 | issue = 3 | pages = 223-5 | month = Mar | year = 1996 | doi = | PMID = 8675733 }}</ref> | *[[EMA]] +ve -- metastatic carcinoma.<ref>{{Cite journal | last1 = Shek | first1 = TW. | last2 = Yuen | first2 = ST. | last3 = Luk | first3 = IS. | last4 = Wong | first4 = MP. | title = Germ cell tumour as a diagnostic pitfall of metastatic carcinoma. | journal = J Clin Pathol | volume = 49 | issue = 3 | pages = 223-5 | month = Mar | year = 1996 | doi = | PMID = 8675733 }}</ref> | ||
*Vimentin. | *[[Vimentin]]. | ||
*Glypican 3 +ve -- [[yolk sac tumour]]. | *[[Glypican 3]] +ve -- [[yolk sac tumour]]. | ||
**Others: A1A +ve -- yolk sac tumour, AFP +ve -- yolk sac tumour. | **Others: A1A +ve -- yolk sac tumour, AFP +ve -- yolk sac tumour. | ||