Difference between revisions of "Mixed epithelial and stromal tumour of the kidney"

From Libre Pathology
Jump to navigation Jump to search
(split out)
 
Line 1: Line 1:
'''Mixed epithelial and stromal tumour of the kidney''', abbreviated '''MEST''' is a rare [[kidney tumour]].
'''Mixed epithelial and stromal tumour of the kidney''', abbreviated '''MEST''', is a rare [[kidney tumour]].


==General==
==General==

Revision as of 02:06, 21 October 2014

Mixed epithelial and stromal tumour of the kidney, abbreviated MEST, is a rare kidney tumour.

General

  • Rare - approx. 1.5% of renal neoplasms.[1]
  • Benign.
  • Prevalence: males > females.

Note:

  • Turbiner et al.[2] have suggested that cystic nephroma and mixed epithelial and stromal tumour (MEST) are one tumour.
    • The lumping term renal epithelial and stromal tumour, abbreviated REST.

Microscopic

Features:

  • Cysts lined by simple epithelium with hobnailing - key feature.
  • Stroma has an ovarian look:
    • Blue (basophilic).
    • Spindle cells.

Notes:

  • Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.

DDx:

Images

IHC

Features:[1]

  • ER +ve.
  • PR +ve.
  • CD10 +ve.

See also

References

  1. 1.0 1.1 Mai, KT.; Elkeilani, A.; Veinot, JP. (Apr 2007). "Mixed epithelial and stromal tumour (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis.". Pathology 39 (2): 235-40. doi:10.1080/00313020701230799. PMID 17454754. Cite error: Invalid <ref> tag; name "pmid17454754" defined multiple times with different content
  2. Turbiner, J.; Amin, MB.; Humphrey, PA.; Srigley, JR.; De Leval, L.; Radhakrishnan, A.; Oliva, E. (Apr 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.". Am J Surg Pathol 31 (4): 489-500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.