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Difference between revisions of "Minimal deviation adenocarcinoma of the uterine cervix"
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Minimal deviation adenocarcinoma of the uterine cervix (view source)
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'''Minimal deviation adenocarcinoma of the uterine cervix''' is | '''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]]. | ||
It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA'''). | It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA'''). | ||
==General== | ==General== | ||
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*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal | last1 = Riegert-Johnson | first1 = D. | last2 = Roberts | first2 = M. | last3 = Gleeson | first3 = FC. | last4 = Krishna | first4 = M. | last5 = Boardman | first5 = L. | title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. | journal = Fam Cancer | volume = 10 | issue = 3 | pages = 463-8 | month = Sep | year = 2011 | doi = 10.1007/s10689-011-9438-x | PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal | last1 = Ito | first1 = M. | last2 = Minamiguchi | first2 = S. | last3 = Mikami | first3 = Y. | last4 = Ueda | first4 = Y. | last5 = Sekiyama | first5 = K. | last6 = Yamamoto | first6 = T. | last7 = Takakura | first7 = K. | title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. | journal = Pathol Res Pract | volume = | issue = | pages = | month = Aug | year = 2012 | doi = 10.1016/j.prp.2012.06.008 | PMID = 22878090 }}</ref> | *Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal | last1 = Riegert-Johnson | first1 = D. | last2 = Roberts | first2 = M. | last3 = Gleeson | first3 = FC. | last4 = Krishna | first4 = M. | last5 = Boardman | first5 = L. | title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. | journal = Fam Cancer | volume = 10 | issue = 3 | pages = 463-8 | month = Sep | year = 2011 | doi = 10.1007/s10689-011-9438-x | PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal | last1 = Ito | first1 = M. | last2 = Minamiguchi | first2 = S. | last3 = Mikami | first3 = Y. | last4 = Ueda | first4 = Y. | last5 = Sekiyama | first5 = K. | last6 = Yamamoto | first6 = T. | last7 = Takakura | first7 = K. | title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. | journal = Pathol Res Pract | volume = | issue = | pages = | month = Aug | year = 2012 | doi = 10.1016/j.prp.2012.06.008 | PMID = 22878090 }}</ref> | ||
*Poor prognosis.<ref name=pmid2764221>{{Cite journal | last1 = Gilks | first1 = CB. | last2 = Young | first2 = RH. | last3 = Aguirre | first3 = P. | last4 = DeLellis | first4 = RA. | last5 = Scully | first5 = RE. | title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. | journal = Am J Surg Pathol | volume = 13 | issue = 9 | pages = 717-29 | month = Sep | year = 1989 | doi = | PMID = 2764221 }}</ref> | *Poor prognosis.<ref name=pmid2764221>{{Cite journal | last1 = Gilks | first1 = CB. | last2 = Young | first2 = RH. | last3 = Aguirre | first3 = P. | last4 = DeLellis | first4 = RA. | last5 = Scully | first5 = RE. | title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. | journal = Am J Surg Pathol | volume = 13 | issue = 9 | pages = 717-29 | month = Sep | year = 1989 | doi = | PMID = 2764221 }}</ref> | ||
Note: | |||
*Very well-differentiated adenocarcinoma may also be seen in the stomach;<ref name=pmid15533229>{{Cite journal | last1 = Nokubi | first1 = M. | last2 = Kawanowa | first2 = K. | last3 = Kawata | first3 = H. | last4 = Hanatsuka | first4 = K. | last5 = Hosoya | first5 = Y. | title = Extremely well-differentiated adenocarcinoma of the gastric cardia: a unique case with columnar cells and laminated stones. | journal = Pathol Int | volume = 54 | issue = 11 | pages = 854-60 | month = Nov | year = 2004 | doi = 10.1111/j.1440-1827.2004.01769.x | PMID = 15533229 }}</ref> however, these do not appear to be related to the well-differentiated adenocarcinoma in the cervix. | |||
==Microscopic== | ==Microscopic== | ||