48,436
edits
Difference between revisions of "Minimal deviation adenocarcinoma of the uterine cervix"
Jump to navigation
Jump to search
Minimal deviation adenocarcinoma of the uterine cervix (view source)
Revision as of 23:18, 13 March 2016
, 23:18, 13 March 2016→IHC
(→IHC) |
|||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
'''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma | '''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma of the uterine cervix]] associated with [[Peutz-Jeghers syndrome]]. | ||
It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA'''). | It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA'''). | ||
It is a subset of ''adenocarcinoma of the uterine cervix'', which is dealt with in the [[adenocarcinoma of the uterine cervix]] article. | |||
==General== | ==General== | ||
| Line 8: | Line 10: | ||
*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal | last1 = Riegert-Johnson | first1 = D. | last2 = Roberts | first2 = M. | last3 = Gleeson | first3 = FC. | last4 = Krishna | first4 = M. | last5 = Boardman | first5 = L. | title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. | journal = Fam Cancer | volume = 10 | issue = 3 | pages = 463-8 | month = Sep | year = 2011 | doi = 10.1007/s10689-011-9438-x | PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal | last1 = Ito | first1 = M. | last2 = Minamiguchi | first2 = S. | last3 = Mikami | first3 = Y. | last4 = Ueda | first4 = Y. | last5 = Sekiyama | first5 = K. | last6 = Yamamoto | first6 = T. | last7 = Takakura | first7 = K. | title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. | journal = Pathol Res Pract | volume = | issue = | pages = | month = Aug | year = 2012 | doi = 10.1016/j.prp.2012.06.008 | PMID = 22878090 }}</ref> | *Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal | last1 = Riegert-Johnson | first1 = D. | last2 = Roberts | first2 = M. | last3 = Gleeson | first3 = FC. | last4 = Krishna | first4 = M. | last5 = Boardman | first5 = L. | title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. | journal = Fam Cancer | volume = 10 | issue = 3 | pages = 463-8 | month = Sep | year = 2011 | doi = 10.1007/s10689-011-9438-x | PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal | last1 = Ito | first1 = M. | last2 = Minamiguchi | first2 = S. | last3 = Mikami | first3 = Y. | last4 = Ueda | first4 = Y. | last5 = Sekiyama | first5 = K. | last6 = Yamamoto | first6 = T. | last7 = Takakura | first7 = K. | title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. | journal = Pathol Res Pract | volume = | issue = | pages = | month = Aug | year = 2012 | doi = 10.1016/j.prp.2012.06.008 | PMID = 22878090 }}</ref> | ||
*Poor prognosis.<ref name=pmid2764221>{{Cite journal | last1 = Gilks | first1 = CB. | last2 = Young | first2 = RH. | last3 = Aguirre | first3 = P. | last4 = DeLellis | first4 = RA. | last5 = Scully | first5 = RE. | title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. | journal = Am J Surg Pathol | volume = 13 | issue = 9 | pages = 717-29 | month = Sep | year = 1989 | doi = | PMID = 2764221 }}</ref> | *Poor prognosis.<ref name=pmid2764221>{{Cite journal | last1 = Gilks | first1 = CB. | last2 = Young | first2 = RH. | last3 = Aguirre | first3 = P. | last4 = DeLellis | first4 = RA. | last5 = Scully | first5 = RE. | title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. | journal = Am J Surg Pathol | volume = 13 | issue = 9 | pages = 717-29 | month = Sep | year = 1989 | doi = | PMID = 2764221 }}</ref> | ||
*Not associated with [[HPV]] - unlike most [[adenocarcinoma of the uterine cervix]]. | |||
Note: | Note: | ||
| Line 24: | Line 27: | ||
DDx:<ref name=pmid12828609/> | DDx:<ref name=pmid12828609/> | ||
*[[Adenocarcinoma of the uterine cervix]] - has "obvious" nuclear atypia. | *[[Adenocarcinoma of the uterine cervix]] - has "obvious" [[nuclear atypia]]. | ||
*[[Tunnel cluster]]. | *[[Tunnel cluster]]. | ||
==IHC== | ==IHC== | ||
Features: | Features: | ||
*CEA +ve.<ref name=pmid2764221/> | *[[CEA]] +ve.<ref name=pmid2764221/> | ||
*p16 -ve.<ref name=pmid21497449>{{Cite journal | last1 = He | first1 = Y. | last2 = Li | first2 = L. | last3 = Jiang | first3 = W. | last4 = Wang | first4 = DQ. | last5 = Xu | first5 = L. | last6 = Huang | first6 = Q. | last7 = Zhang | first7 = Y. | last8 = Yang | first8 = KX. | title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. | journal = Pathol Res Pract | volume = 207 | issue = 5 | pages = 295-9 | month = May | year = 2011 | doi = 10.1016/j.prp.2011.02.011 | PMID = 21497449 }}</ref> | *[[p16]] -ve.<ref name=pmid21497449>{{Cite journal | last1 = He | first1 = Y. | last2 = Li | first2 = L. | last3 = Jiang | first3 = W. | last4 = Wang | first4 = DQ. | last5 = Xu | first5 = L. | last6 = Huang | first6 = Q. | last7 = Zhang | first7 = Y. | last8 = Yang | first8 = KX. | title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. | journal = Pathol Res Pract | volume = 207 | issue = 5 | pages = 295-9 | month = May | year = 2011 | doi = 10.1016/j.prp.2011.02.011 | PMID = 21497449 }}</ref> | ||
==See also== | ==See also== | ||