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'''Microorganisms''' show-up every once in a while.  It is essential to know 'em.
'''Microorganisms''' show-up every once in a while.  It is essential to know 'em.


==Microorganisms==
=Microorganisms=
 
==Fungi==
{| class="wikitable"
{| class="wikitable sortable"
|-
|-
! Name (disease)
! Name (disease)
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! Image
! Image
|-
|-
| Aspergillus (aspergillosis)
| Aspergillus ([[aspergillosis]])
| Fungi
| Fungi
| ?
| ?
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| ? Immunosuppression
| ? Immunosuppression
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://commons.wikimedia.org/w/index.php?title=File:Pulmonary_aspergillosis.jpg Aspergillus (WC)], [http://commons.wikimedia.org/wiki/File:Pulmonary_aspergillosis_cytology.jpg Aspergillus cytology (WC)]
| [[Image:Pulmonary_aspergillosis.jpg|thumb|center|150px| Aspergillus. (WC)]]
|-
|-
| Zygomycota (zygomycosis);<br>''more specific''<br>Mucorales (mucormycosis)
| Zygomycota ([[zygomycosis]]);<br>''more specific''<br>Mucorales (mucormycosis)
| Fungi
| Fungi
| ?
| ?
| '''Branching hyphae with variable width'''
| '''Branching hyphae with variable width'''
| ?
| ?
| Granulomata assoc.
| [[Granulomata]] assoc.
| Diabetes, immunodeficient
| Diabetes, immunodeficient
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://granuloma.homestead.com/ZygoHE_02.jpg Mucormycosis (homestead.com)], [http://commons.wikimedia.org/wiki/File:Zygomycosis.jpg Zygomycosis (WC)]
| [[Image:Zygomycosis.jpg |thumb|center|150px| Zygomycosis. (WC)]]
|-
|-
| Coccidioides, usually C. immitis<br>(coccidioidomycosis)
| Coccidioides, usually C. immitis<br>(coccidioidomycosis)
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| Immunodeficient
| Immunodeficient
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://pathmicro.med.sc.edu/mycology/cocc3.jpg Coccidioidomycosis (med.sc.edu)] [http://commons.wikimedia.org/wiki/File:Coccidioides_immitis_on_Sabouraud%27s_medium.jpg C. immitis (WC)]
| [http://pathmicro.med.sc.edu/mycology/cocc3.jpg Coccidioidomycosis (med.sc.edu)] [[Image:Coccidioides_immitis_on_Sabouraud%27s_medium.jpg |thumb|center|150px|C. immitis (WC)]]  
|-
|-
| Histoplasma (histoplasmosis)
| Histoplasma ([[histoplasmosis]])
| Fungi
| Fungi
| 2-5 micrometers
| 2-5 micrometers
| Spherical
| Spherical
| GMS
| [[GMS]]
| '''Intracellular (unlike candida), granulomata'''
| '''Intracellular (unlike candida), granulomata'''
| Source: soil with bird droppings
| Source: soil with bird droppings
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://commons.wikimedia.org/wiki/File:Histoplasma_pas-d.jpg Histoplasmosis (WC)]
| [[Image:Histoplasma_pas-d.jpg|thumb|center|150px| Histoplasmosis. (WC)]]
|-
|-
| Blastomyces (Blastomycosis)
| Blastomyces ([[blastomycosis]])
| Fungi
| Fungi
| 5-15 micrometres
| 5-15 micrometres
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| Habitat: Northeast America, Africa
| Habitat: Northeast America, Africa
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref><ref>[http://pathmicro.med.sc.edu/mycology/mycology-6.htm http://pathmicro.med.sc.edu/mycology/mycology-6.htm]</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref><ref>[http://pathmicro.med.sc.edu/mycology/mycology-6.htm http://pathmicro.med.sc.edu/mycology/mycology-6.htm]</ref>
| [http://pathmicro.med.sc.edu/mycology/blast1.jpg Blastomyces]
| [[Image:Blastomycosis_cropped.JPG | thumb|center|150px|Blastomyces. (WC)]]
|-
|-
| Paracoccidioides (Paracoccidioidomycosis)
| Paracoccidioides ([[paracoccidioidomycosis]])
| Fungi
| Fungi
| 6-60 micrometres
| 6-60 micrometres
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| Clinical???
| Clinical???
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://commons.wikimedia.org/wiki/File:Paracoccidioides_brasiliensis_01.jpg P. brasiliensis (WC)].
| [[Image:Paracoccidioides_brasiliensis_01.jpg |thumb|center|150px|P. brasiliensis (WC)]]
|-
|-
| Pneumocystis jirovecii (Pneumocystis carinii pneumonia; abbrev. PCP)
| Pneumocystis jirovecii ([[pneumocystis carinii pneumonia]]; abbrev. PCP)
| Fungi (previously thought to be a protozoan)
| Fungi (previously thought to be a protozoan)
| 7-8 micrometres
| 7-8 micrometres
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| [[HIV]]/AIDS associated
| [[HIV]]/AIDS associated
| <ref name=Ref_APBR684>{{Ref APBR|684}}</ref>
| <ref name=Ref_APBR684>{{Ref APBR|684}}</ref>
| [http://commons.wikimedia.org/wiki/File:Pneumocystosis_carinii_of_lung_in_AIDS_959_lores.jpg PCP (WC)]
| [[Image:Pneumocystosis_carinii_of_lung_in_AIDS_959_lores.jpg|thumb|center|150px| PCP. (WC)]]
|-
|-
| Cryptococcosis
| Cryptococcus ([[cryptococcosis]])
| Fungi  
| Fungi  
| 5-15 micrometres
| 5-15 micrometres
Line 93: Line 93:
| HIV/AIDS associated, most common CNS fungus
| HIV/AIDS associated, most common CNS fungus
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| <ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
| [http://commons.wikimedia.org/wiki/File:Cryptococcosis_of_lung_in_patient_with_AIDS_Methenamine_silver_stain_963_lores.jpg Crytococcosis - methenamine silver (WC)], [http://commons.wikimedia.org/wiki/File:Cryptococcosis_of_lung_in_patient_with_AIDS._Mucicarmine_stain_962_lores.jpg Crytococcosis - mucicarmine (WC)].
| [[Image:Cryptococcosis_of_lung_in_patient_with_AIDS._Mucicarmine_stain_962_lores.jpg |thumb|center|150px| Crytococcosis - mucicarmine (WC)]]
|}
|}
Notes:
Notes:
*'''Bold''' text = key features.
*'''Bold''' text = key features.


==Fungi==
=Fungi=
{{Main|Fungi}}
*There are lots of 'em.  Below are a few of 'em.
*There are lots of 'em.  Below are a few of 'em.


Line 110: Line 111:
===Tissue invasive fungi===
===Tissue invasive fungi===
Typically:<ref>CM 17 Apr 2009.</ref>
Typically:<ref>CM 17 Apr 2009.</ref>
*Mucor
*Mucor.
*Aspergillus
*Aspergillus.


==Histoplasmosis==
===List===
*''Histoplasma capulatum'' - primative fungus, typical location: lung.
*[[Histoplasmosis]].
** Often in yeast form in tissue 2-5 micrometres.<ref name=Ref_WMSP103>{{Ref WMSP|103}}</ref>
*[[Coccidioidomycosis]].
** Nice bright red on PAS-D - [http://en.wikipedia.org/wiki/File:Histoplasma_pas-d.jpg histoplasmosis (wikipedia.org)].
*[[Pneumocystis pneumonia]].
*[[Cryptococcus]].
*[[Cryptosporidiosis]].
*[[Candidiasis]].
*[[Blastomycosis]].
*[[Mucormycosis]].


==Coccidiomycosis==
=Worms & stuff=
*''Coccidioides immitis'' - fungus, from soil, typical locations: lung, oral cavity.<ref name=Ref_WMSP3>{{Ref WMSP|3}}</ref>
** Forms spherules 60-80 micrometres in size.<ref name=Ref_WMSP103>{{Ref WMSP|103}}</ref>
** [http://commons.wikimedia.org/wiki/File:Mature_spherule_with_endospores_of_Coccidioides_immitis_PHIL_480_lores.jpg Coccidioides (commons.wikimedia.org)].


==Pneumocystis pneumonia (PCP) ==
==Schistosomiasis==
*''Pneumocystis jirovecii'' (used to be called ''Pneumocystis carinii'') - fungus (that used to be considered a parasite), typical location: lung.
:''See [[Urine cytopathology]]''.
**Clinical: Opportunistic infection. May have subtle finding on chest x-ray.
===General===
**"Dented ping-pong ball" appearance;<ref name=Ref_WMSP103>{{Ref WMSP|103}}</ref> - remember '''P'''C'''P''' = '''p'''ing-'''p'''ong.
*Trematode, i.e. type of worm.
**Approximately 7-8 micrometres in size - [http://commons.wikimedia.org/wiki/File:Pneumocystosis_carinii_of_lung_in_AIDS_959_lores.jpg PCP (WP)].  [http://commons.wikimedia.org/w/index.php?title=Special%3ASearch&search=Pneumocystis+carinii&go=Go Several images are here (WC)].


==Cryptococcus==
*Due to:
*Usually ''C. neoformans'', fungus - opportunistic infection, typical location: lung.
**''Schistosoma mansoni''.
*Most common fungus seen in CSF specimens.<ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
**''Schistosoma haematobium''.
**''Schistosoma japonicum''
*''S. haematobium'' infection associated with [[squamous cell carcinoma of the urinary bladder]].
**Classically presents with hematuria.


Appearance:
===Microscopic===
*Yeast:
Features of ova (''S. haematobium''):<ref>URL: [http://path.upmc.edu/cases/case622/dx.html http://path.upmc.edu/cases/case622/dx.html]. Accessed on: 26 January 2012.</ref>
**Round/ovoid 5-15 micrometres (may resemble Histoplasma or Candida -- but often larger).
* Elliptical ~140 micrometres max dimension.
**Thick mucopolysacchardie capsule + refractile centre.<ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
* "Spike" approx. the size of a [[PMN]].  
**"Tear drop-shapped" budding pattern (useful to differentiate from Blastomyces, Histoplasma).<ref name=Ref_APBR682>{{Ref APBR|682}}</ref>


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Cryptococcosis_of_lung_in_patient_with_AIDS._Mucicarmine_stain_962_lores.jpg Micrograph of crytococcosis - mucicarmine stain (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Cryptococcosis_of_lung_in_patient_with_AIDS_Methenamine_silver_stain_963_lores.jpg Micrograph of crytococcosis - methenamine silver stain (WC)].
Image:Schistosomiasis_haematobia.jpg | Schistosomiasis haematobia. (WC)
Image:Schistosoma japonicum (1) histopathology.JPG | Schistosoma japonicum. (WC/KGH)
Image:Schistosoma japonicum (2) histopathology.JPG | Schistosoma japonicum. (WC/KGH)
Image:Schistosoma japonicum (3) histopathology.JPG | Schistosoma japonicum. (WC/KGH)
Image:Schistosoma_-_intermed_mag.jpg | Schistosoma eggs - intermed. mag. (WC/Nephron)
Image:Schistosoma_-_very_high_mag.jpg | Schistosoma eggs - very high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case622.html Schistosomiasis - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case622/images/fig08.jpg Comparison of Schistosome eggs (upmc.edu/Lancet)].
 
==Toxoplasma==
===General===
*Common CNS infection.
**''Toxoplasma gondii'' - pathogenic; causes ''toxoplasmosis''.
*Previously classified as a ''protozoa''.
*A [[TORCH infection]].
 
===Microscopic===
General:
*Tachyzoites (Invasive form):
**Crescent-shaped organisms that are 2-3μm wide by 4-8μm long.
*Bradyzoites:
**Are founded within the tissue cysts and are shorter than tachyzoites.
*Oocysst:
**Ovoid shape that measures 10μm to 12μm and contains four sporozoites.
 
*Histopathological features depend on location in body.


==Cryptosporidiosis==
====Lymph node====
*Uniform spherical nodules 2-4 micrometres in diameter, typical location - GI tract brush border.
LN features:<ref name=Ref_ILNP113>{{Ref ILNP|113}}</ref>
*Tip-off -- '''key feature''' -- bluish staining of brush border
*Reactive germinal centers (pale areas - larger than usual).
*Images:
**Often poorly demarcated - due to loose epithelioid cell clusters at germinal center edge - '''key feature'''.
**[http://www.co.hennepin.mn.us/portal/site/HCInternet/menuitem.3f94db53874f9b6f68ce1e10b1466498/?vgnextoid=bab360a6bb9fc010VgnVCM1000000f094689RCRD Micrograph of cryptosporidium in the gallbladder (hennepin.mn.us)].
*Epithelioid cells - perifollicular & intrafollicular.
**[http://www.tulane.edu/~wiser/protozoology/notes/images/cp_path.gif Schematic picture of cryptosporidium & bowel (tulane.edu)].
**Loose aggregates of histiocytes (do not form round granulomas):
**[http://www.brown.edu/Courses/Digital_Path/systemic_path/GI/cryptosporidiosis.html Micrograph of cryptosporidiosis (brown.edu)].
***Abundant pale cytoplasm.
***Nucleoli.
*Monocytoid cells (monocyte-like cells) - in cortex & paracortex.
**Large cells in islands/sheets '''key feature''' with:
***Abundant pale cytoplasm - '''important'''.  
***Well-defined cell border - '''important'''.
***Singular nucleus.  
**Cell clusters usually have interspersed neutrophils.


Notes:
Images (lymph node):
*Cryptosporidium parvum?<ref>[http://www.dpd.cdc.gov/dpdx/HTML/Cryptosporidiosis.htm http://www.dpd.cdc.gov/dpdx/HTML/Cryptosporidiosis.htm]</ref>
*[http://commons.wikimedia.org/wiki/File:Toxoplasmosis_lymphadenopathy_-_low_mag.jpg Toxoplasmosis - low mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Toxoplasmosis_lymphadenopathy_-_high_mag.jpg Toxoplasmosis - high mag. (WC)].


==Candidiasis==
====CNS====
*Commonly ''Candida albicans'' - yeast (fungus), locations: oral cavity, vagina.
CNS features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I001-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I001-PQ01-M.htm]. Accessed on: 19 October 2010.</ref>
*''Dimorphic'' - seen in two forms:
*Granular appearing ball ~ 2x the size of resting lymphocyte.
**Pseudohyphae<ref name=Ref_WMSP3>{{Ref WMSP|3}}</ref>  - collections of many ''C. albicans'' cells in a branching pattern.
**Yeast form - single cells, 10 to 12 micrometres in diameter, gram positive.<ref>[http://pathmicro.med.sc.edu/mycology/mycology-3.htm http://pathmicro.med.sc.edu/mycology/mycology-3.htm]</ref>  
*Stains: PAS, methenamine silver.
*Images:
**[http://pathmicro.med.sc.edu/mycology/candi4.jpg Candida (pseudohyphae) - methenamine silver (med.sc.edu)].
**[http://commons.wikimedia.org/wiki/File:Candida_pap_1.jpg Candida on Pap test (WC)].


==Blastomycosis==
=====Images (CNS)=====  
*Usually ''Blastomyces dermatitidis'' - fungus.
<gallery>
*May be in the oral cavity.<ref name=Ref_WMSP3>{{Ref WMSP|3}}</ref>
Image:Toxoplasmosis_-_cropped_-_very_high_mag.jpg | CNS toxoplasmosis - very high mag. (WC)
*Histology = '''B'''road-based budding yeast -- is '''B'''lastomyces.<ref name=pmid12375640>PMID 12375640</ref>
Image:Toxoplasmosis_-_ihc_-_very_high_mag.jpg | CNS toxoplasmosis - IHC - very high mag. (WC)
**The interface between two separating fungi, i.e. fungi in the process of reproducing, is very large.
</gallery>
*Images:
www:
**[http://commons.wikimedia.org/wiki/File:Blastomycosis_cropped.JPG Blastomycosis (wikimedia.org)].
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I001-PQ01-M.htm CNS toxoplasmosis (ouhsc.edu)].
**[http://www.pathguy.com/lectures/blastomycosis.jpg Blastomycosis - budding (pathguy.com)].
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FND5IE01-Toxoplasmosis-Micro.htm CNS toxoplasmosis (ouhsc.edu)].
**[http://www.lahey.org/Medical/InfectiousDiseases/ID_Blastomycosis.asp Blastomycosis - with broad budding (lahey.org)].
*[http://path.upmc.edu/cases/case350.html Toxoplasmosis - several images (upmc.edu)].


====Heart====
Features:
*Intramuscular organisms.


==Mucormycosis==
DDx:
===General===
*[[Chagas disease]]. (???)
*Causative organism: Mucorales.
**Kingdom: Fungi.
**AKA ''Zygomycota'' (zygomycosis).
*Assoc. with diabetes, immunodeficiency.


===Histology===
Images (heart):
Features:<ref name=Ref_APBR682>{{Ref APBR|682}}</ref>
*[http://path.upmc.edu/cases/case160.html Toxoplasmosis (upmc.edu)].
*Branching hyphae variable width.
*Granulomata associated.


Image:
===IHC===
*[http://commons.wikimedia.org/wiki/File:Zygomycosis.jpg Zygomycosis - cytology (WC)].
*IHC for toxoplasma.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I001-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I001-PQ01-M.htm]. Accessed on: 19 October 2010.</ref>
*[http://granuloma.homestead.com/ZygoHE_02.jpg Mucormycosis (homestead.com)].


==Worms==
==Strongyloidiasis==
===General===
*Causes by worm ''Strongyloides  stercoralis''.
*High case mortality rate ~ 70%.<ref name=pmid15337730>{{Cite journal  | last1 = Lim | first1 = S. | last2 = Katz | first2 = K. | last3 = Krajden | first3 = S. | last4 = Fuksa | first4 = M. | last5 = Keystone | first5 = JS. | last6 = Kain | first6 = KC. | title = Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. | journal = CMAJ | volume = 171 | issue = 5 | pages = 479-84 | month = Aug | year = 2004 | doi = 10.1503/cmaj.1031698 | PMID = 15337730 }}</ref>
*May present after years of latency due to immune suppression.<ref name=pmid11528578>{{Cite journal  | last1 = Siddiqui | first1 = AA. | last2 = Berk | first2 = SL. | title = Diagnosis of Strongyloides stercoralis infection. | journal = Clin Infect Dis | volume = 33 | issue = 7 | pages = 1040-7 | month = Oct | year = 2001 | doi = 10.1086/322707 | PMID = 11528578 }}</ref>


==Strongyloides==
Location:
*Lung?
*Lung. (???)


===Microscopic===
Features:
Features:
*Long worms.
*Long worms.
*~10-15 micrometers wide.
*~10-15 micrometers wide.
====Images====
<gallery>
Image:Strongyloides_stercoralis_larva.jpg | Strongyloides. (WC)
</gallery>
www:
*[http://www.totallyfreeimages.com/121316/This-micrograph-reveals-adult-strongyloides-nematodes-located-am Strongyloides (CDC/totallyfreeimages.com)].
*[http://www.sciencephoto.com/media/116331/enlarge Strongyloides (sciencephoto.com)].


==Echinococcus==
==Echinococcus==
*Echinococcus granulosus.
*Several species - most common: ''Echinococcus granulosus''.
*Causes ''hydatid disease'' in the liver.
*Causes ''[[hydatid disease]]'' in the [[liver]].


===Microscopic===
Features:
Features:
*Hooklets.
*Laminated wall +/- calcification.<ref name=Ref_PBPoD8_448>{{Ref PCPBoD8|448}}</ref>
*Scoleces - knoblike anterior end of a tapeworm.<ref>[http://www.thefreedictionary.com/scoleces http://www.thefreedictionary.com/scoleces]. Accessed on: 10 January 2010.</ref>
*Organisms:
**Hooklets.
**Scoleces - knoblike anterior end of a tapeworm.<ref>[http://www.thefreedictionary.com/scoleces http://www.thefreedictionary.com/scoleces]. Accessed on: 10 January 2010.</ref>


==Enterobius vermicularis==
==Enterobius vermicularis==
*AKA ''pinworm''.
*AKA ''pinworm''.
===General===
*Classically found in a [[vermiform appendix]] removed for appendicitis that does not have [[acute appendicitis]].<ref name=pmid7945067>{{Cite journal  | last1 = Dahlstrom | first1 = JE. | last2 = Macarthur | first2 = EB. | title = Enterobius vermicularis: a possible cause of symptoms resembling appendicitis. | journal = Aust N Z J Surg | volume = 64 | issue = 10 | pages = 692-4 | month = Oct | year = 1994 | doi =  | PMID = 7945067 }}</ref>
**See: ''[[Vermiform appendix#Enterobius vermicularis]]''.


Features:<ref name=Ref_APBR685>{{Ref APBR|685}}</ref>
===Gross===
*Ovoid eggs - double walled shells, one side flat.
*Peri-anal white squiggly thing ~ 2-13 mm in length.


Images:
Image:
*[http://commons.wikimedia.org/wiki/File:Pinworms_in_the_Appendix_%281%29.jpg Pinworm (WC)].
*[http://www.dijitalimaj.com/alamyDetail.aspx?img={14157DA6-DBE8-4E03-BE4A-69591588E153} Pinworm (dijitalimaj.com)].


==Viruses==
===Microscopic===
Many virus afflicit humans. Only a few of them can be diagnosed histologically.
Features - organism:
*0.2-0.5 mm width x 2-13 mm length.
*Characteristic triangular "spikes" seen on cross section - base x height ~ 30 x 30 μm.
**''Spikes'' is in quotations, as these are really a longitudinal blade-like ridges, that run the length of the worm.  


==Viral inclusions==
Features - eggs:<ref name=Ref_APBR685>{{Ref APBR|685}}</ref>  
Cowdry types:<ref>URL: [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970864-6&figureId=fig3&ecomponentId=mmc3 http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970864-6&figureId=fig3&ecomponentId=mmc3]. Accessed: 12 January 2010.</ref>
*Ovoid - double walled shells, one side flat.
*Cowdry type A inclusion:<ref>URL: [http://www.whonamedit.com/synd.cfm/3495.html http://www.whonamedit.com/synd.cfm/3495.html]. Accessed on: 22 January 2010.</ref>
**Round eosinophilic material surrounded by a clear halo.
*Cowdry type B inclusion:<ref>[http://www.whonamedit.com/synd.cfm/3496.html http://www.whonamedit.com/synd.cfm/3496.html]. Accessed on: 22 January 2010.</ref>
**Neuropathology thingy. (???)


Images:
====Images====
*[http://www.daff.gov.au/animal-plant-health/pests-diseases-weeds/aquatic_animal_diseases_significant_to_australia_identification_field_guide/diseases_of_crustaceans/viral_diseases_of_crustaceans/infectious_hypodermal_and_haematopoietic_necrosis/histological_page_for_infectious_hypodermal_and_haematopoietic_necrosis Cowdry A inclusion (daff.gov.au)].
www:
*[http://focosi.altervista.org/pathohomoprocess_regressive.html Cowdry type A & type B inclusions (altervista.org)].
*[http://www.brown.edu/Courses/Digital_Path/systemic_path/GI/enterobius.html Enterobius (brown.edu)].
<gallery>
Image:Enterobius_-_very_low_mag.jpg | Enterobius - very low mag. (WC)
Image:Enterobius_-_high_mag.jpg | Enterobius - high mag. (WC)
Image:Pinworms_in_the_Appendix_%281%29.jpg | Pinworm (WC)
</gallery>
==Trichinella==
===General===
*Causes ''Trichinosis''.
**Classically associated with uncooked pork.<ref name=pmid17072975>{{cite journal |author=Kaewpitoon N, Kaewpitoon SJ, Philasri C, ''et al.'' |title=Trichinosis: epidemiology in Thailand |journal=World J. Gastroenterol. |volume=12 |issue=40 |pages=6440–5 |year=2006 |month=October |pmid=17072975 |doi= |url=http://www.wjgnet.com/1007-9327/12/6440.asp}}</ref>
*Several types; most due to ''T. spiralis''.<ref name=pmid17072975/>
 
===Microscopic===
Features:
*Worm.


==Herpes simplex virus (HSV)==
Image:
*Canker sores - usually HSV-1.
*[http://www.microbiologybytes.com/introduction/Paraquiz/QUIZ06A.html Muscle bx with trichinella (microbiologybytes.com)].
*Genital herpes - usually HSV-2.
*[http://library.med.utah.edu/WebPath/jpeg2/MUSC010.jpg Trichinella (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html]. Accessed on: 5 December 2010.</ref>


===Histology/cytology===
==Cysticercosis==
Features:<ref>SM. 11 January 2010.</ref>
===General===
*Clear "ground glass" nuclei.
*Caused by ''Taenia solium''; pork tapeworm.
**Rim of peripheral chromatin.
*May cause [[epilepsy]]; most common parasitic CNS infection.<ref name=pmid19208982>{{cite journal |author=Prasad KN, Prasad A, Verma A, Singh AK |title=Human cysticercosis and Indian scenario: a review |journal=J. Biosci. |volume=33 |issue=4 |pages=571–82 |year=2008 |month=November |pmid=19208982 |doi= |url=}}</ref>
*Nuclear inclusions.
*Multinucleation with nuclear molding, i.e. multiple nuclei that touch over a large surface area.


Mnemonic - 3 Ms: Margination, Multinucleation, Molding.
===Gross===
*Multiple cystic spaces.


Images:
Image:
*[http://www.virology.org/sbpgphoto2.html Herpes simplex virus - multinucleation (virology.org)].
*[http://reference.medscape.com/features/slideshow/neurocysticercosis Neurocysticercosis (medscape.com)].
*[http://commons.wikimedia.org/wiki/File:Herpes_simplex_virus_pap_test.jpg HSV on a Pap test - showing multinucleation (WC)].
*[http://commons.wikimedia.org/wiki/File:Herpes_esophagitis_-_very_high_mag.jpg HSV esophagitis - very high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Herpes_esophagitis_-_intermed_mag.jpg HSV esophagitis - intermed. mag. (WC)].


==Cytomegalovirus (CMV)==
===Microscopic===
Features:
Features:
*Very large nucleus (as the name implies) with clearing.
*Large ovoid body with complex structures (cross-section of worm) - size: millimetres.
*Granular cytoplasmic inclusions (red on H&E sections).
**+/-External eosinophilic microvilli.
**+/-Gastrointestinal tract - ovoid structure within the worm.
 
Notes:
*Histomorphology is not distinctive for the type... microbiology usually figures it out.


Images:
Images:
*[http://commons.wikimedia.org/wiki/File:CMV_placentitis2_mini.jpg CMV placentitis (WC)].
*[http://www.dpd.cdc.gov/dpdx/html/imagelibrary/A-F/Cysticercosis/body_Cysticercosis_il1.htm Cysticercosis (cdc.gov)].
*[http://www.sciencephoto.com/media/116340/enlarge Cysticercosis (sciencephoto.com)].
*[http://path.upmc.edu/cases/case154.html Neurocysticercosis - case 1 (upmc.edu)].
*[http://path.upmc.edu/cases/case376.html Neurocysticercosis - case 2 (upmc.edu)].


==Adenovirus==
==Rhinosporidiosis==
Features:
:'''''Not''' to be confused with [[rhinoscleroma]]''.
*"Smudge" cells<ref>URL: [http://www.pathguy.com/lectures/infect.htm http://www.pathguy.com/lectures/infect.htm]. Accessed on: 8 July 2010.</ref> - black/blue blob ~ 15 micrometers. (???)
===General===
**Affects endothelial cells. (???)
*Caused by parasite ''Rinosporidium seeberi''.
**India, Sri Lanka.
*Nasal mass.
**May present with obstruction.<ref name=pmid16945122/>
 
===Microscopic===
Features:<ref>URL: [http://www.histopathology-india.net/Rhino.htm http://www.histopathology-india.net/Rhino.htm]. Accessed on: 4 January 2012.</ref><ref name=pmid16945122/>
*Globular cysts ~ 100 micrometers with endospores:
**Hyperchromatic (blue) spherical 10-100 micrometer.


Images:
Images:
*[http://img.medscape.com/fullsize/migrated/438/534/cc438534.haur.fig1.jpg Adenovirus (medscape.com)].<ref>URL:[http://www.medscape.com/viewarticle/438534_2 http://www.medscape.com/viewarticle/438534_2]. Accessed on: 8 July 2010.</ref>
*[http://www.arquivosdeorl.org.br/conteudo/imagesFORL/11-02-19-fig01-ing.gif Rhinosporidiosis (arquivosdeorl.org.br)].<ref>URL: [http://www.arquivosdeorl.org.br/conteudo/acervo_eng.asp?id=428 http://www.arquivosdeorl.org.br/conteudo/acervo_eng.asp?id=428]. 4 January 2012.</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560165/figure/F1/ Rhinosporidiosis (nih.gov)].<ref name=pmid16945122>{{Cite journal  | last1 = Morelli | first1 = L. | last2 = Polce | first2 = M. | last3 = Piscioli | first3 = F. | last4 = Del Nonno | first4 = F. | last5 = Covello | first5 = R. | last6 = Brenna | first6 = A. | last7 = Cione | first7 = A. | last8 = Licci | first8 = S. | title = Human nasal rhinosporidiosis: an Italian case report. | journal = Diagn Pathol | volume = 1 | issue =  | pages = 25 | month =  | year = 2006 | doi = 10.1186/1746-1596-1-25 | PMID = 16945122 |PMC = 1560165 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560165/?tool=pubmed}}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560165/figure/F2/ Rhinosporidiosis (nih.gov)].


==Parvo B19==
===Stains===
*[[GMS stain]] +ve organisms.
 
==Leishmaniasis==
===General===
*Caused by protozoa in the group ''Leishmania'' group.
*Transmitted to humans by the ''sand fly''.
 
May be:
*Cutaneous.<ref name=pmid20377337>{{Cite journal  | last1 = Goto | first1 = H. | last2 = Lindoso | first2 = JA. | title = Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. | journal = Expert Rev Anti Infect Ther | volume = 8 | issue = 4 | pages = 419-33 | month = Apr | year = 2010 | doi = 10.1586/eri.10.19 | PMID = 20377337 }}</ref>
*Mucocutaneous.<ref name=pmid20377337/>
*Visceral.<ref name=pmid19708817>{{Cite journal  | last1 = den Boer | first1 = ML. | last2 = Alvar | first2 = J. | last3 = Davidson | first3 = RN. | last4 = Ritmeijer | first4 = K. | last5 = Balasegaram | first5 = M. | title = Developments in the treatment of visceral leishmaniasis. | journal = Expert Opin Emerg Drugs | volume = 14 | issue = 3 | pages = 395-410 | month = Sep | year = 2009 | doi = 10.1517/14728210903153862 | PMID = 19708817 }}</ref>
 
===Microscopic===
Features:
Features:
*Big red nuclear inclusion.<ref>URL: [http://www.pathguy.com/lectures/infect.htm http://www.pathguy.com/lectures/infect.htm]. Accessed on: 8 July 2010.</ref>
*Small ~1-2 micrometers.
 
====Images====
<gallery>
Image:Leishmania_donovani_01.png | Leishmania - smear. (WC)
Image:Leishmania_2009-04-14_smear.JPG | Leishmania - bone marrow. (WC)
Image:Cutaneous_Leishmaniasis_x100 | Leishmania - cutaneous. (WC)
</gallery>
www:
*[http://www.cdc.gov/parasites/leishmaniasis/index.html Leishmania and sand fly (cdc.gov)].
 
===Stains===
*[[Giemsa stain]] - highlights organisms.
 
=Viruses=
{{Main|Viruses}}
This is a fairly big topic.  There are about half a dozen viral inclusions (e.g. [[CMV]], [[HSV]], [[VZV]], [[adenovirus]]) a decent pathologist ought to be able to identify.  The ''virus'' article covers 'em.
 
=Bacteria=
{{Main|Bacteria}}
This is a small topic when considered from the perspective of an anatomical pathologist.  Most stuff is sorted-out by microbiology.
 
=Protozoa=
A historical category of organisms. Lifeforms previously categorized as ''protozoa'' are in several different ''kingdoms''.
{{Main|Amebiasis}}
{{Main|Leishmaniasis}}
{{Main|Pneumocystis jirovecii}}
{{Main|Toxoplasma}}
 
=Microorganisms and cancer=
==Viruses and cancer==
A number of microorganisms are associated with the development of cancer:<ref>{{Ref PCPBoD8|168}}</ref>
*[[Human papillomavirus]] (HPV) - cancer of cervix, vulva, vagina, penis, anus, head & neck.
*[[Epstein-Barr virus]] - [[Burkitt lymphoma]], [[Post-transplant lymphoproliferative disorder]], classical [[Hodgkin lymphoma]] (all but ''[[Nodular sclerosis Hodgkin lymphoma|nodular sclerosis HL]]''), [[nasopharyngeal carcinoma]].
*[[Hepatitis B]] - [[HCC]].
*[[Hepatitis C]] - [[HCC]].
*[[Lymphoma#Adult_T-cell_leukemia.2Flymphoma|Human T-cell lymphotropic virus type I]] (HTLV-1) - [[Adult T-cell leukemia/lymphoma]].
*[[Human herpesvirus-8]] (HHV-8) - [[Kaposi sarcoma]], [[primary effusion lymphoma]], body cavity lymphoma.
*[[Merkel cell carcinoma|Merkel cell polyomavirus]] - [[Merkel cell carcinoma]].
 
==Bacteria and cancer==
*[[Helicobacter pylori]] - [[MALT lymphoma]], [[gastric carcinoma]].
 
==Parasites and cancer==
*[[Schistosoma haematobium]] - [[squamous cell carcinoma of the urinary bladder]].
*Clonorchis sinensis (AKA Opisthorchis sinensis) - [[cholangiocarcinoma]].
*Opisthorchis viverrini - [[cholangiocarcinoma]].


==See also==
=See also=
*[[Staining]].
*[[Staining]].
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
*[[Viruses]].


==References==
=References=
{{reflist|2}}
{{reflist|2}}


=External links=
*[http://www.fujita-hu.ac.jp/~tsutsumi/index.html Pathology of Infectious Diseases (fujita-hu.ac.jp)].


[[Category:Basics]]
[[Category:Basics]]
[[Category:Microorganisms]]
Michael
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