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Difference between revisions of "Microcystic adnexal carcinoma"
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Microcystic adnexal carcinoma (view source)
Revision as of 18:48, 3 March 2022
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| LMDDx = [[sclerosing basal cell carcinoma]], desmoplastic [[trichoepithelioma]], infiltrative [[squamous cell carcinoma]] | | LMDDx = [[sclerosing basal cell carcinoma]], desmoplastic [[trichoepithelioma]], infiltrative [[squamous cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = Ber-EP4 -ve, CD15 -ve | | IHC = [[Ber-EP4]] -ve, CD15 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 14: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[skin]] - | | Site = [[skin]] - usually head and neck | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 33: | Line 33: | ||
*Adults. | *Adults. | ||
*Very rare<ref name=pmid21606063>{{Cite journal | last1 = Tawfik | first1 = AM. | last2 = Kreft | first2 = A. | last3 = Wagner | first3 = W. | last4 = Vogl | first4 = TJ. | title = MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. | journal = Br J Radiol | volume = 84 | issue = 1002 | pages = e114-7 | month = Jun | year = 2011 | doi = 10.1259/bjr/44068180 | PMID = 21606063 }}</ref> ~ 150 cases in world literature in 2001.<ref name=pmid11298716/> | *Very rare<ref name=pmid21606063>{{Cite journal | last1 = Tawfik | first1 = AM. | last2 = Kreft | first2 = A. | last3 = Wagner | first3 = W. | last4 = Vogl | first4 = TJ. | title = MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. | journal = Br J Radiol | volume = 84 | issue = 1002 | pages = e114-7 | month = Jun | year = 2011 | doi = 10.1259/bjr/44068180 | PMID = 21606063 }}</ref> ~ 150 cases in world literature in 2001.<ref name=pmid11298716/> | ||
*Uncommonly metastases. | *Uncommonly metastases.<ref name=pmid11298716/> | ||
==Gross== | ==Gross== | ||
*Typical location: head and neck.<ref name=pmid11298716/><ref name=pmid16549917>{{Cite journal | last1 = Gabillot-Carré | first1 = M. | last2 = Weill | first2 = F. | last3 = Mamelle | first3 = G. | last4 = Kolb | first4 = F. | last5 = Boitier | first5 = F. | last6 = Petrow | first6 = P. | last7 = Ortoli | first7 = JC. | last8 = Margulis | first8 = A. | last9 = Souteyrand | first9 = P. | title = Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. | journal = Dermatology | volume = 212 | issue = 3 | pages = 221-8 | month = | year = 2006 | doi = 10.1159/000091248 | PMID = 16549917 }}</ref> | *Typical location: head and neck.<ref name=pmid11298716/><ref name=pmid16549917>{{Cite journal | last1 = Gabillot-Carré | first1 = M. | last2 = Weill | first2 = F. | last3 = Mamelle | first3 = G. | last4 = Kolb | first4 = F. | last5 = Boitier | first5 = F. | last6 = Petrow | first6 = P. | last7 = Ortoli | first7 = JC. | last8 = Margulis | first8 = A. | last9 = Souteyrand | first9 = P. | title = Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. | journal = Dermatology | volume = 212 | issue = 3 | pages = 221-8 | month = | year = 2006 | doi = 10.1159/000091248 | PMID = 16549917 }}</ref> | ||
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*Infiltrative [[squamous cell carcinoma]]. | *Infiltrative [[squamous cell carcinoma]]. | ||
===Images=== | |||
www: | |||
*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref> | *[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov)].<ref name=pmid21606063/> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23398472 >{{Cite journal | last1 = Sellheyer | first1 = K. | last2 = Nelson | first2 = P. | last3 = Kutzner | first3 = H. | last4 = Patel | first4 = RM. | title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. | journal = J Cutan Pathol | volume = 40 | issue = 4 | pages = 363-70 | month = Apr | year = 2013 | doi = 10.1111/cup.12085 | PMID = 23398472 }}</ref> | Features:<ref name=pmid23398472 >{{Cite journal | last1 = Sellheyer | first1 = K. | last2 = Nelson | first2 = P. | last3 = Kutzner | first3 = H. | last4 = Patel | first4 = RM. | title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. | journal = J Cutan Pathol | volume = 40 | issue = 4 | pages = 363-70 | month = Apr | year = 2013 | doi = 10.1111/cup.12085 | PMID = 23398472 }}</ref> | ||
*BerEP4 -ve. | *[[BerEP4]] -ve. | ||
**Positive in [[sclerosing basal cell carcinoma]]. | **Positive in [[sclerosing basal cell carcinoma]]. | ||
*CK15 -ve. | *CK15 -ve. | ||
**Positive in DTE. | **Positive in DTE. | ||
**Negative in sclerosing BCC. | **Negative in sclerosing BCC. | ||
*EMA +ve. | |||
**Negative in sclerosing BCC and desmoplastic trichoepithelioma. | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Dermatologic neoplasms]] | [[Category:Dermatologic neoplasms]] | ||