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'''Meningioma''' a very common [[CNS tumours|tumour]] in [[neuropathology]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Meningioma_high_mag.jpg
| Width      =
| Caption    = Meningioma. [[HPS stain]].
| Synonyms  =
| Micro      = whorled appearance, calcification - [[psammoma bodies|psammomatous]], +/-[[nuclear pseudoinclusions]]
| Subtypes  = Grade I (meningothelial, fibrous, transistional, psammomatous, angiomatous, microcystic, secretory, lymphoplasmacyte-rich, metaplastic), Grade II (invasive, clear cell, chordoid), Grade III (papillary, rhabdoid)
| LMDDx      = [[schwannoma]], [[solitary fibrous tumour]], [[hemangiopericytoma]], others
| Stains    =
| IHC        = EMA +ve, [[keratins]] usu. -ve, CD34 -ve/+ve, S-100 -ve (usu.), PR +ve (-ve in more aggressive ones)
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = see ''[[CNS tumours]]''
| Assdx      =
| Syndromes  = [[Neurofibromatosis|neurofibromatosis 2]], [[nevoid basal cell carcinoma syndrome]]
| Clinicalhx = +/-radiation
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      = extra-axial, intradural lesion, dural tail sign (on MRI)
| Endoscopy  =
| Prognosis  = usually benign, dependent on grade
| Other      =
| ClinDDx    = dependent on site - see ''[[CNS tumours]]''
| Tx        = surgical removal
}}
'''Meningioma''' a very common [[CNS tumours|tumour]] in [[neuropathology]].  


==General==
==General==
===Prevalence===
===Prevalence===
*Common.
*Most common primary brain tumour.<ref name=pmid25343186>{{Cite journal  | last1 = Rogers | first1 = L. | last2 = Barani | first2 = I. | last3 = Chamberlain | first3 = M. | last4 = Kaley | first4 = TJ. | last5 = McDermott | first5 = M. | last6 = Raizer | first6 = J. | last7 = Schiff | first7 = D. | last8 = Weber | first8 = DC. | last9 = Wen | first9 = PY. | title = Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. | journal = J Neurosurg | volume =  | issue =  | pages = 1-20 | month = Oct | year = 2014 | doi = 10.3171/2014.7.JNS131644 | PMID = 25343186 }}</ref>
*May be caused by prior radiation.
*May be caused by prior radiation.<ref name=pmid25249493>{{Cite journal  | last1 = Baldi | first1 = I. | last2 = Engelhardt | first2 = J. | last3 = Bonnet | first3 = C. | last4 = Bauchet | first4 = L. | last5 = Berteaud | first5 = E. | last6 = Grüber | first6 = A. | last7 = Loiseau | first7 = H. | title = Epidemiology of meningiomas. | journal = Neurochirurgie | volume =  | issue =  | pages =  | month = Sep | year = 2014 | doi = 10.1016/j.neuchi.2014.05.006 | PMID = 25249493 }}</ref>
*Women develop meningioma twice as likely as men.<ref>{{Cite journal  | last1 = Wiemels | first1 = J. | last2 = Wrensch | first2 = M. | last3 = Claus | first3 = EB. | title = Epidemiology and etiology of meningioma. | journal = J Neurooncol | volume = 99 | issue = 3 | pages = 307-14 | month = Sep | year = 2010 | doi = 10.1007/s11060-010-0386-3 | PMID = 20821343 }}</ref>
*More than 90% are solitary.


===Radiology===
===Prognosis===
*Extra-axial.
*Most are benign - usu. a good prognosis.
**Even benign tumors may show extensive local spread - considerable morbidity and mortality.
**Metastases are rare and then usu. after surgery.
*May be malignant - bad prognosis.


===Prognosis===
*Factors associated with unfavourable prognosis:
*Most are benign.
**BAP1 mutations.<ref>{{Cite journal  | last1 = Shankar | first1 = GM. | last2 = Abedalthagafi | first2 = M. | last3 = Vaubel | first3 = RA. | last4 = Merrill | first4 = PH. | last5 = Nayyar | first5 = N. | last6 = Gill | first6 = CM. | last7 = Brewster | first7 = R. | last8 = Bi | first8 = WL. | last9 = Agarwalla | first9 = PK. | title = Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. | journal = Neuro Oncol | volume = 19 | issue = 4 | pages = 535-545 | month = 04 | year = 2017 | doi = 10.1093/neuonc/now235 | PMID = 28170043 }}</ref>
**May be malignant.
**Presence of TERT promotor mutation.<ref>{{Cite journal  | last1 = Sahm | first1 = F. | last2 = Schrimpf | first2 = D. | last3 = Olar | first3 = A. | last4 = Koelsche | first4 = C. | last5 = Reuss | first5 = D. | last6 = Bissel | first6 = J. | last7 = Kratz | first7 = A. | last8 = Capper | first8 = D. | last9 = Schefzyk | first9 = S. | title = TERT Promoter Mutations and Risk of Recurrence in Meningioma. | journal = J Natl Cancer Inst | volume = 108 | issue = 5 | pages =  | month = May | year = 2016 | doi = 10.1093/jnci/djv377 | PMID = 26668184 }}</ref>
**Loss of H3K27me3.<ref>{{Cite journal  | last1 = Katz | first1 = LM. | last2 = Hielscher | first2 = T. | last3 = Liechty | first3 = B. | last4 = Silverman | first4 = J. | last5 = Zagzag | first5 = D. | last6 = Sen | first6 = R. | last7 = Wu | first7 = P. | last8 = Golfinos | first8 = JG. | last9 = Reuss | first9 = D. | title = Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence. | journal = Acta Neuropathol | volume =  | issue =  | pages =  | month = Apr | year = 2018 | doi = 10.1007/s00401-018-1844-9 | PMID = 29627952 }}</ref>


===Genetics===
===Genetics===
*May be seen in genetic disorders such as:
*May be seen in genetic disorders such as:
**[[Neurofibromatosis|Neurofibromatosis 2 (NF2)]].<Ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm]. Accessed on: 26 October 2010.</ref>
**[[Neurofibromatosis|Neurofibromatosis 2 (NF2)]].<Ref>URL: [http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm http://moon.ouhsc.edu/kfung/jty1/neurotest/Q13-Ans.htm]. Accessed on: 26 October 2010.</ref>
**[[Nevoid basal cell carcinoma syndrome]] (Gorlin syndrome).
**[[Nevoid basal cell carcinoma syndrome]] (Gorlin syndrome).<ref name=pmid15545745>{{Cite journal  | last1 = Kimonis | first1 = VE. | last2 = Mehta | first2 = SG. | last3 = Digiovanna | first3 = JJ. | last4 = Bale | first4 = SJ. | last5 = Pastakia | first5 = B. | title = Radiological features in 82 patients with nevoid basal cell carcinoma (NBCC or Gorlin) syndrome. | journal = Genet Med | volume = 6 | issue = 6 | pages = 495-502 | month =  | year =  | doi = 10.109701.GIM.0000145045.17711.1C | PMID = 15545745 }}</ref><ref>{{Cite journal  | last1 = Lee | first1 = CW. | last2 = Tan | first2 = TC. | title = Meningioma associated with Gorlin's syndrome. | journal = J Clin Neurosci | volume = 21 | issue = 2 | pages = 349-50 | month = Feb | year = 2014 | doi = 10.1016/j.jocn.2013.02.033 | PMID = 24100109 }}</ref>
**[[Cowden syndrome]].
 
===Quick overview===
{| class="wikitable sortable"
! Name
! Histologic criteria
! Subtypes
! Image
|-
| Classic, WHO I
| less then 4 mit/10 HPF and no atypia
| meningeothelial, fibroblastic, transitional, psammomatous, angiomatous, microcytsic, secretory, lymphoplasmacyte-rich, metaplastic
| [[File:Miningioma_(1)_transitional_type.jpg|thumb|center|150px]]
|-
| Atypical, WHO II
| brain invasion, 4  or more mit/10 HPF, or 3 of the following: necrosis, increased cellularity, high nuc:cyto ratio, nucleoli, sheeting
| chordoid, clear cell
| [[File:Brain_invasion_meningioma.jpg|thumb|center|150px]]
|-
| Anaplastic, WHO III
| 20 or more mitoses/10 HPF, morphologiy similiar to carcinoma or sarcoma
| rhabdoid, papillary
| [[File:Mitoses_anaplastic_meningioma.jpg|thumb|center|150px]]
|}
 
==Gross/Radiology==
*Extra-axial, intradural.
**Can be extradural - very rare.<ref name=upmc_case702>URL: [http://path.upmc.edu/cases/case702.html http://path.upmc.edu/cases/case702.html]. Accessed on: 2 February 2012.</ref>
*[[Dural tail sign]] (DTS) on MRI.<ref name=pmid22839655>{{Cite journal  | last1 = Ikeda | first1 = D. | last2 = Chiocca | first2 = EA. | title = Editorial: dural tail sign. | journal = J Neurosurg | volume = 117 | issue = 4 | pages = 643-4 | month = Oct | year = 2012 | doi = 10.3171/2012.2.JNS12266 | PMID = 22839655 }}</ref><ref name=pmid25238986>{{Cite journal  | last1 = Wen | first1 = M. | last2 = Jung | first2 = S. | last3 = Moon | first3 = KS. | last4 = Pei | first4 = J. | last5 = Lee | first5 = KH. | last6 = Jin | first6 = SG. | last7 = Li | first7 = SY. | last8 = Ryu | first8 = HH. | title = Immunohistochemical profile of the dural tail in intracranial meningiomas. | journal = Acta Neurochir (Wien) | volume = 156 | issue = 12 | pages = 2263-73 | month = Dec | year = 2014 | doi = 10.1007/s00701-014-2216-4 | PMID = 25238986 }}</ref>
**Enhancement of dura adjacent to the mass lesion - commonly seen (~70% of cases).<ref name=pmid2120998>{{Cite journal  | last1 = Aoki | first1 = S. | last2 = Sasaki | first2 = Y. | last3 = Machida | first3 = T. | last4 = Tanioka | first4 = H. | title = Contrast-enhanced MR images in patients with meningioma: importance of enhancement of the dura adjacent to the tumor. | journal = AJNR Am J Neuroradiol | volume = 11 | issue = 5 | pages = 935-8 | month =  | year =  | doi =  | PMID = 2120998 }}</ref>
**May be subclassified radiologically - predictive of grading.<ref name=pmid22839654>{{Cite journal  | last1 = Qi | first1 = ST. | last2 = Liu | first2 = Y. | last3 = Pan | first3 = J. | last4 = Chotai | first4 = S. | last5 = Fang | first5 = LX. | title = A radiopathological classification of dural tail sign of meningiomas. | journal = J Neurosurg | volume = 117 | issue = 4 | pages = 645-53 | month = Oct | year = 2012 | doi = 10.3171/2012.6.JNS111987 | PMID = 22839654 }}</ref>
*+/-Hyperostosis.
**Associated with invasion into the skull in ~20% of cases.<ref name=pmid22406780>{{Cite journal  | last1 = Goyal | first1 = N. | last2 = Kakkar | first2 = A. | last3 = Sarkar | first3 = C. | last4 = Agrawal | first4 = D. | title = Does bony hyperostosis in intracranial meningioma signify tumor invasion? A radio-pathologic study. | journal = Neurol India | volume = 60 | issue = 1 | pages = 50-4 | month =  | year =  | doi = 10.4103/0028-3886.93589 | PMID = 22406780 }}</ref>
 
<gallery>
File:Keilbeinmeningeom MRT T1KMax.jpg | Sphenoid wing meningioma (WC/Hellerhoff)
File:Meningioma.jpg | Brain displacement by meningioma (AFIP)
File:Meningioma-1.jpg | Macroscopy (Всеволод Лучанский (vvray))
</gallery>


==Microscopic==
==Microscopic==
Features (memory device ''WCN''):
Features (memory device ''WCN''):
*Whorled appearance - '''key feature'''.
*Whorled appearance - '''key feature'''.
*Calcification, psammomatous (target-like appearance; (tight) onion skin).
*Calcification, [[psammoma bodies|psammomatous]] (target-like appearance; (tight) onion skin).
*+/-[[Nuclear pseudoinclusions]] - focal nuclear clearing with a sharp interface to unremarkable chromatin.
*+/-[[Nuclear pseudoinclusions]] - focal nuclear clearing with a sharp interface to unremarkable chromatin.
Images:
*[http://commons.wikimedia.org/wiki/File:Meningioma_high_mag.jpg Meningioma - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Meningioma_intermed_mag.jpg Meningioma - intermed. mag. (WC)].
*[http://www.neuropathologyweb.org/chapter7/chapter7dMiscellaneous.html Meningioma (neuropathologyweb.org)].
*[http://commons.wikimedia.org/wiki/File:Meningioma_-_brain_invasion_-_intermed_mag.jpg Meningioma with brain invasion - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Meningioma_-_brain_invasion_-_high_mag.jpg Meningioma with brain invasion - high mag. (WC)].


Notes:
Notes:
*May involute into benign sclerotic tissue.<ref>URL: [http://radiographics.rsna.org/content/23/3/785.long http://radiographics.rsna.org/content/23/3/785.long]. Accessed on: 3 November 2010.</ref>
*May involute into benign sclerotic tissue.<ref>URL: [http://radiographics.rsna.org/content/23/3/785.long http://radiographics.rsna.org/content/23/3/785.long]. Accessed on: 3 November 2010.</ref>
*Thick-walled blood vessels = feature of [[schwannoma]].
*Thick-walled blood vessels -> think [[schwannoma]].
 
DDx:
*[[Schwannoma]] - especially at [[CP angle]].
*[[Solitary fibrous tumour]].
*[[Hemangiopericytoma]].
*Others - see subtypes.
 
===Images===
<Gallery>
Image:Meningioma_high_mag.jpg | Meningioma - high mag. (WC)
Image:Meningioma_intermed_mag.jpg | Meningioma - intermed. mag. (WC)
Image:Meningioma_-_brain_invasion_-_intermed_mag.jpg | Meningioma with brain invasion - intermed. mag. (WC)
Image:Meningioma_-_brain_invasion_-_high_mag.jpg | Meningioma with brain invasion - high mag. (WC)
File:Meningeotheliomatous_meningeoma_whorl_formations.jpg | Whorls in meningioma. (WC)
File:Image NP T1c 0001.JPG | Whorls in meningioma. (WC)
File:Image NP T1c 0004.JPG | Meningioma annotated. (WC)
</gallery>
www:
*[http://www.neuropathologyweb.org/chapter7/chapter7dMiscellaneous.html Meningioma (neuropathologyweb.org)].
*[http://path.upmc.edu/cases/case702.html Extra-dural meningioma (upmc.edu)].


===Morphologic subtypes===
===Morphologic subtypes===
Line 47: Line 134:
Microscopic:  
Microscopic:  
*Syncytial, nuclear clearing ([[pseudoinclusions]]).
*Syncytial, nuclear clearing ([[pseudoinclusions]]).
*Whorls, Onion bulb formations.
*Few psammoma bodies.
Molecular:
*AKT E17K mutations.<ref>{{Cite journal  | last1 = Sahm | first1 = F. | last2 = Bissel | first2 = J. | last3 = Koelsche | first3 = C. | last4 = Schweizer | first4 = L. | last5 = Capper | first5 = D. | last6 = Reuss | first6 = D. | last7 = Böhmer | first7 = K. | last8 = Lass | first8 = U. | last9 = Göck | first9 = T. | title = AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry. | journal = Acta Neuropathol | volume = 126 | issue = 5 | pages = 757-62 | month = Nov | year = 2013 | doi = 10.1007/s00401-013-1187-5 | PMID = 24096618 }}</ref>
<gallery>
Meningeotheliomatous_meningeoma_whorl_formations.jpg | Syncytial appearance, whorl formations (WC/jensflorian)
File:Meningioma_showing_Psammoma_body.jpg | Psammoma body (WC/Netha Hussain)
File:Meningioma_cytologie.jpg | Onion bulb formation in smear (WC/jensflorian)
File:Meningioma_intermed_mag.jpg | Meningioma HPS stain (WC/Nephron)
</gallery>


=====Fibrous meningioma=====  
=====Fibrous meningioma=====  
*AKA fibroblastic.
*[[AKA]] ''fibroblastic meningioma''.
*Not collagen but looks like it. (It is really laminin or fibronectin).
*'''Not''' collagen... but looks like it.  
**It is really laminin or fibronectin.
*Spindle cells in parallel bundles.
*Few to none whorl formations.
 
<gallery>
File:Meningioma_fibromatous_variant.jpg | Fibrous meingioma (WC)
File:Miningioma_(4)_EMA.JPG | EMA staining (WC/marvin 101)
</gallery>
 
=====Transitional meningioma=====
*AKA mixed.
*Common.
*Lobular and fasicular growth patterns coexist.
*Usu. a mixture of meningeothelial and fibromatous meningioma


=====Transistional meningioma=====
<gallery>
*Rare.
File:Miningioma_(1)_transitional_type.jpg | Low power (WC/KGH)
File:Miningioma_(2)_transitional_type.jpg | Intermed magnification (WC/KGH)
File:Prominent mitosis meningioma.jpg | Mitosis in a transitional meningioma (WC/jensflorian)
</gallery>


=====Psammomatous meningioma=====
=====Psammomatous meningioma=====
Microscopic:  
Microscopic:  
*[[Psammoma bodies]].
*[[Psammoma bodies]] dominate over tumor cells.
**Irregular calcifications (confluent psammoma bodies).
*Usually found in spinal cord.
 
<gallery>
File:Psammomatous_meningioma.jpg | Numerous psammoma bodies (WC/jensflorian)
File:NP psammomatous meningioma 0002.jpg | Psammomatous meningioma after EDTA treatment (WC)
</gallery>


=====Angiomatous meningioma=====
=====Angiomatous meningioma=====
*AKA vascular.
*AKA vascular.
*May bleed like stink.
*May bleed like stink.
*May show extensive edema.
*Hyalinized vessels dominate over tumor cells.
*Degenerative nuclear atypia.
DDx:
*Vascular malformatons
*Hemangioblastoma
<gallery>
File:Angiomatous_meningioma_HE_x100.jpg | Angiomatous meningioma (WC/jensflorian)
</gallery>


=====Microcystic meningioma=====
=====Microcystic meningioma=====
Microscopic:  
Microscopic:  
*Cystic appearance.
*Cystic appearance.
*Increased cytologic pleomorphism of the elongated cells.
DDx:
*Clear cell meningioma
*Hemangioblastoma
<gallery>
File:Microcystic_meningeoma_HE_x100.jpg | Microcyts (WC/jensflorian)
</gallery>


=====Secretory meningioma=====
=====Secretory meningioma=====
Line 71: Line 214:


Microscopic:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 12 October 2011.</ref>  
Microscopic:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 12 October 2011.</ref>  
*Eosinophilic intracytoplasmic inclusions that are CEA +ve and PAS +ve.
*Eosinophilic intracytoplasmic inclusions that are [[CEA]] +ve and [[PAS]] +ve.
 
Molecular:
* Combined KLF4 K409Q and TRAF7 mutations.<ref>{{Cite journal  | last1 = Reuss | first1 = DE. | last2 = Piro | first2 = RM. | last3 = Jones | first3 = DT. | last4 = Simon | first4 = M. | last5 = Ketter | first5 = R. | last6 = Kool | first6 = M. | last7 = Becker | first7 = A. | last8 = Sahm | first8 = F. | last9 = Pusch | first9 = S. | title = Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. | journal = Acta Neuropathol | volume = 125 | issue = 3 | pages = 351-8 | month = Mar | year = 2013 | doi = 10.1007/s00401-013-1093-x | PMID = 23404370 }}</ref>


DDx:
DDx:
*Metastatic [[mucinous adenocarcinoma]].
*Metastatic [[mucinous adenocarcinoma]].
*Pituitary adenoma
<gallery>
File:Secretory_meningioma_HE_x200.jpg | Secretory granules (WC/jensflorian)
File:Secretory_meningioma_PAS.jpg | PAS-positive secretory granules (WC/jensflorian)
File:Secretory_meningioma_HE_smear.jpg | Smear with secretory granules (WC/jensflorian)
</gallery>


Image:
Images:
*[http://moon.ouhsc.edu/kfung/jty1/Com04/Com04Image/Com405-1-8.gif Secretory meningioma (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 3 January 2012.</ref>
*[http://moon.ouhsc.edu/kfung/jty1/Com04/Com04Image/Com405-1-8.gif Secretory meningioma (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 3 January 2012.</ref>
*[http://path.upmc.edu/cases/case370.html Secretory meningioma - several images (upmc.edu)].


=====Lymphoplasmacyte-rich meningioma=====
=====Lymphoplasmacyte-rich meningioma=====
Line 85: Line 239:


Images:
Images:
*[http://path.upmc.edu/cases/case225/micro.html Lymphoplasmacyte-rich meningioma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case225/micro.html Lymphoplasmacyte-rich meningioma - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case247/micro.html Lymphoplasmacyte-rich meningioma - case 2 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case528.html Lymphoplasmacyte-rich meningioma - case 3 - several images (upmc.edu)].


=====Metaplastic meningioma=====
=====Metaplastic meningioma=====
*Much talked about... but very rare.
*No clinical significance.
*Probably do not represent true metaplasia in all cases.
*Clincal information is rquired to distinguish between bone invasion and meningiomas with bone formation.


Microscopic:  
Microscopic:  
*Cartilage or bone formation.
*Cartilage or bone formation.
*Myxoid or xanthomatous changes.
<gallery>
File:Metaplastic_osseous_meningioma.jpg | Ossified meningioma, HE stain. (WC/jensflorian)
File:Metaplastic_xanthomatous_meningioma.jpg | Metaplastic meningioma with xanthomatous changes. (WC/jensflorian)
</gallery>


====Grade II====
====Grade II====
=====Invasive meningioma=====  
=====Brain invasive meningioma=====  
*Invades the brain.
*Invades the brain (irregular, tongue-like).
*Absence of leptomeningeal layer.
*Brain invasion can be present in grade I tumors, these are then classified as "atypical", ie. as grade II tumors.
*The prognostic significance of brain invasion is still unclear, some studies do not show a course similiar to grade II meningiomas.<ref>{{Cite journal  | last1 = Baumgarten | first1 = P. | last2 = Gessler | first2 = F. | last3 = Schittenhelm | first3 = J. | last4 = Skardelly | first4 = M. | last5 = Tews | first5 = DS. | last6 = Senft | first6 = C. | last7 = Dunst | first7 = M. | last8 = Imoehl | first8 = L. | last9 = Plate | first9 = KH. | title = Brain invasion in otherwise benign meningiomas does not predict tumor recurrence. | journal = Acta Neuropathol | volume = 132 | issue = 3 | pages = 479-81 | month = Sep | year = 2016 | doi = 10.1007/s00401-016-1598-1 | PMID = 27464983 }}</ref><ref>{{Cite journal  | last1 = Brokinkel | first1 = B. | last2 = Hess | first2 = K. | last3 = Mawrin | first3 = C. | title = Brain invasion in Meningiomas - Clinical considerations and impact of neuropathological evaluation: A systematic Review. | journal = Neuro Oncol | volume =  | issue =  | pages =  | month = Apr | year = 2017 | doi = 10.1093/neuonc/nox071 | PMID = 28419308 }}</ref><ref>{{Cite journal  | last1 = Pizem | first1 = J. | last2 = Velnar | first2 = T. | last3 = Prestor | first3 = B. | last4 = Mlakar | first4 = J. | last5 = Popovic | first5 = M. | title = Brain invasion assessability in meningiomas is related to meningioma size and grade, and can be improved by extensive sampling of the surgically removed meningioma specimen. | journal = Clin Neuropathol | volume = 33 | issue = 5 | pages = 354-63 | month =  | year =  | doi = 10.5414/NP300750 | PMID = 25034703 }}</ref>


Images:
Images:
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE18-Meningioma-Invasion.htm Meningioma with brain invasion (ouhsc.edu)].
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE18-Meningioma-Invasion.htm Meningioma with brain invasion (ouhsc.edu)].
<gallery>
File:Brain invasion meningioma.jpg | Finger-like protrusions, HE (WC/jensflorian)
File:Meningioma - brain invasion - very high mag.jpg | Brain invasive meningooma (WC/Nephron)
</gallery>


=====Clear cell meningioma=====
=====Clear cell meningioma=====
Line 106: Line 278:
Microscopic:  
Microscopic:  
*Clear cells - contain glycogen (PAS +ve).
*Clear cells - contain glycogen (PAS +ve).
<gallery>
File:HE_clear_cell_meningioma.jpg | Clear cell meningioma, HE (WC/jensflorian)
</gallery>
Molecular:
*SMARCE1 mutations.<ref>{{Cite journal  | last1 = Smith | first1 = MJ. | last2 = Wallace | first2 = AJ. | last3 = Bennett | first3 = C. | last4 = Hasselblatt | first4 = M. | last5 = Elert-Dobkowska | first5 = E. | last6 = Evans | first6 = LT. | last7 = Hickey | first7 = WF. | last8 = van Hoff | first8 = J. | last9 = Bauer | first9 = D. | title = Germline SMARCE1 mutations predispose to both spinal and cranial clear cell meningiomas. | journal = J Pathol | volume = 234 | issue = 4 | pages = 436-40 | month = Dec | year = 2014 | doi = 10.1002/path.4427 | PMID = 25143307 }}</ref>


Images:
Images:
Line 115: Line 294:


Microscopic:  
Microscopic:  
*Myxoid appearance.
*[[Myxoid]] appearance.
 
<gallery>
File:Chordoid meningoma HE x200.jpg | Chordoid meningioma - HE (WC/jensflorian)
File:Alcian blue chordoid meningioma.jpg | Chordoid meningioma - alcian blue (WC/jensflorian)
</gallery>
 


Image:
Image:
Line 123: Line 308:
=====Papillary meningioma=====
=====Papillary meningioma=====
Microscopic:  
Microscopic:  
*True papillae.
*discohesive meningothelial tumour cells around a fibrovascular core.
*perivascular pseudorosettes.
 
<gallery>
File:Papillary meningioma HE.jpg | Papillary meningioma (WC/jensflorian)
File:Pap meningioma.jpg | Papillary meningioma (WC)
</gallery>
 
=====Rhabdoid meningioma=====
=====Rhabdoid meningioma=====
Microscopic:  
Microscopic:  
*Rhabdoid appearance (abundant cytoplasm).
*Rhabdoid appearance (abundant cytoplasm).
**Cross-striations.
<gallery>
Image:Rhabdoid Meningioma Histopathology.jpg | Rhabdoid meningioma. (WC/Marvin 101)
File:Rhabdoid meningioma frozen section HE.jpg | Frozen section (WC/jensflorian)
</gallery>
www:
*[http://path.upmc.edu/cases/case373.html Rhabdoid meningioma - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case393.html Rhabdoid meningioma - case 2 - several images (upmc.edu)].
====Other morphological variants====
These are currently not listed in the WHO as separate entities.
*Oncocytic.<ref>{{Cite journal  | last1 = Zunarelli | first1 = E. | last2 = Tallarico | first2 = E. | last3 = Valentini | first3 = A. | last4 = Maiorana | first4 = A. | title = Oncocytic meningioma: study of eight new cases and analysis of 13 reported cases. | journal = Pathology | volume = 42 | issue = 6 | pages = 587-9 | month =  | year = 2010 | doi = 10.3109/00313025.2010.508740 | PMID = 20854082 }}</ref>
*Whorling-sclerosing.<ref>{{Cite journal  | last1 = Haberler | first1 = C. | last2 = Jarius | first2 = C. | last3 = Lang | first3 = S. | last4 = Rössler | first4 = K. | last5 = Gruber | first5 = A. | last6 = Hainfellner | first6 = JA. | last7 = Budka | first7 = H. | title = Fibrous meningeal tumours with extensive non-calcifying collagenous whorls and glial fibrillary acidic protein expression: the whorling-sclerosing variant of meningioma. | journal = Neuropathol Appl Neurobiol | volume = 28 | issue = 1 | pages = 42-7 | month = Feb | year = 2002 | doi =  | PMID = 11849562 }}</ref>
*Rosette-forming.<ref>{{Cite journal  | last1 = Liverman | first1 = C. | last2 = Mafra | first2 = M. | last3 = Chuang | first3 = SS. | last4 = Shivane | first4 = A. | last5 = Chakrabarty | first5 = A. | last6 = Highley | first6 = R. | last7 = Hilton | first7 = DA. | last8 = Byrne | first8 = NP. | last9 = Wesseling | first9 = P. | title = A clinicopathologic study of 11 rosette-forming meningiomas: a rare and potentially confusing pattern. | journal = Acta Neuropathol | volume = 130 | issue = 2 | pages = 311-3 | month = Aug | year = 2015 | doi = 10.1007/s00401-015-1456-6 | PMID = 26106026 }}</ref>
<gallery>
File:Meningioma_Whorling_sclerosing.jpg | Whorling-sclerosing features in meningioma (HE/jensflorian)
File:Meningioma_pseudorosettes.jpg | Meningioma with rosette-forming features (HE/jensflorian)
</gallery>


===Histologic grading===
===Histologic grading===
Line 135: Line 347:
*Grade 2 (either #1, #2 or #3):  
*Grade 2 (either #1, #2 or #3):  
*#Brain-invasive meningioma.
*#Brain-invasive meningioma.
*#*Protrusion of meningioma into brain.
*#*Invasion of meningioma into brain.
*#**Meninogioma with entraped GFAP +ve tissue.
*#**Meninogioma with entraped GFAP +ve tissue.
*#Atypical meningioma (by histomorphology) - either ''A'' or ''B''.
*#Atypical meningioma (by histomorphology) - either ''A'' or ''B''.
Line 155: Line 367:


==IHC==
==IHC==
*EMA +ve.<ref name=Ref_PSNP13>{{Ref PSNP|13}}</ref>
*EMA +ve (approx. 90%).<ref name=Ref_PSNP13>{{Ref PSNP|13}}</ref>
*Other CKs usually -ve.
*PR +ve (approx. 75%, expression decreases from grade I to III).
*SSTR2A +ve (approx. 95%).
*S100 variable (up to 35% cases, usually patchy).<ref>{{cite journal |vauthors=Behling F, Fodi C, Skardelly M, Paulsen F, Tabatabai G, Honegger J, Tatagiba M, Schittenhelm J |title=The prognostic role of the immunohistochemical expression of S100 in meningiomas |journal=J Cancer Res Clin Oncol |volume= |issue= |pages= |date=July 2022 |pmid=35838837 |doi=10.1007/s00432-022-04186-9 |url=}}</ref>
*SOX10 -ve.
*GFAP -ve.
*CD34 usu. -ve (approx 8% cases positive).
*CD13 +ve.<ref>{{cite journal |vauthors=Marletta S, Luchini C, Sperandio N, Torresani E, Sorio A, Girolami I, Scarpa A, Eccher A, Ghimenton C |title=CD13 is a useful tool in the differential diagnosis of meningiomas with potential biological and prognostic implications |journal=Virchows Arch |volume=480 |issue=6 |pages=1223–1230 |date=June 2022 |pmid=35212813 |pmc=9184408 |doi=10.1007/s00428-022-03304-9 |url=}}</ref>
*Other CKs usually -ve (approx 6% cases positive, mostly secretory meningiomas).
 
==Molecular==
Non-syndromal meningiomas may show AKT1/TRAF7, SMO, KLF4/TRAF7, and PIK3CA mutations (1/3 of cases).<ref>{{Cite journal  | last1 = Clark | first1 = VE. | last2 = Erson-Omay | first2 = EZ. | last3 = Serin | first3 = A. | last4 = Yin | first4 = J. | last5 = Cotney | first5 = J. | last6 = Ozduman | first6 = K. | last7 = Avşar | first7 = T. | last8 = Li | first8 = J. | last9 = Murray | first9 = PB. | title = Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. | journal = Science | volume = 339 | issue = 6123 | pages = 1077-80 | month = Mar | year = 2013 | doi = 10.1126/science.1233009 | PMID = 23348505 }}</ref>
*AKT/TRAF7 mutations are usually basal and associated with meningothelial histology.
*KLF4/TRAF7 mutations are highly specific for secretory histology.
*TRAF7 mutations are the first step and occur thorughout the WD40 domain. <ref>{{cite journal |vauthors=Dogan H, Blume C, Patel A, Jungwirth G, Sogerer L, Ratliff M, Ketter R, Herold-Mende C, Jones DTW, Wick W, Vollmuth P, Zweckberger K, Reuss D, von Deimling A, Sahm F |title=Single-cell DNA sequencing reveals order of mutational acquisition in TRAF7/AKT1 and TRAF7/KLF4 mutant meningiomas |journal=Acta Neuropathol |volume=144 |issue=4 |pages=799–802 |date=October 2022 |pmid=35984495 |doi=10.1007/s00401-022-02485-6 |url=}}</ref>
 
Intraventricular meningiomas have NF2 mutations.
<ref>{{cite journal |vauthors=Jungwirth G, Warta R, Beynon C, Sahm F, von Deimling A, Unterberg A, Herold-Mende C, Jungk C |title=Intraventricular meningiomas frequently harbor  NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT |journal=Acta Neuropathol Commun |volume=7 |issue=1 |pages=140 |date=August 2019 |pmid=31470906 |pmc=6716845 |doi=10.1186/s40478-019-0793-4 |url=}}</ref>
 
Several inherited diseases are associated with meningiomas:
*[[Neurofibromatosis]] type II<ref>{{Cite journal  | last1 = Fontaine | first1 = B. | last2 = Rouleau | first2 = GA. | last3 = Seizinger | first3 = BR. | last4 = Menon | first4 = AG. | last5 = Jewell | first5 = AF. | last6 = Martuza | first6 = RL. | last7 = Gusella | first7 = JF. | title = Molecular genetics of neurofibromatosis 2 and related tumors (acoustic neuroma and meningioma). | journal = Ann N Y Acad Sci | volume = 615 | issue =  | pages = 338-43 | month =  | year = 1991 | doi =  | PMID = 2039155 }}</ref>
*Germline SMARCE1 and SMARCB1 mutations<ref>{{Cite journal  | last1 = Smith | first1 = MJ. | last2 = O'Sullivan | first2 = J. | last3 = Bhaskar | first3 = SS. | last4 = Hadfield | first4 = KD. | last5 = Poke | first5 = G. | last6 = Caird | first6 = J. | last7 = Sharif | first7 = S. | last8 = Eccles | first8 = D. | last9 = Fitzpatrick | first9 = D. | title = Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. | journal = Nat Genet | volume = 45 | issue = 3 | pages = 295-8 | month = Mar | year = 2013 | doi = 10.1038/ng.2552 | PMID = 23377182 }}</ref><ref>{{Cite journal  | last1 = van den Munckhof | first1 = P. | last2 = Christiaans | first2 = I. | last3 = Kenter | first3 = SB. | last4 = Baas | first4 = F. | last5 = Hulsebos | first5 = TJ. | title = Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri. | journal = Neurogenetics | volume = 13 | issue = 1 | pages = 1-7 | month = Feb | year = 2012 | doi = 10.1007/s10048-011-0300-y | PMID = 22038540 }}</ref>
*Loss of SUFU (SHH-Pathway).<ref>{{Cite journal  | last1 = Aavikko | first1 = M. | last2 = Li | first2 = SP. | last3 = Saarinen | first3 = S. | last4 = Alhopuro | first4 = P. | last5 = Kaasinen | first5 = E. | last6 = Morgunova | first6 = E. | last7 = Li | first7 = Y. | last8 = Vesanen | first8 = K. | last9 = Smith | first9 = MJ. | title = Loss of SUFU function in familial multiple meningioma. | journal = Am J Hum Genet | volume = 91 | issue = 3 | pages = 520-6 | month = Sep | year = 2012 | doi = 10.1016/j.ajhg.2012.07.015 | PMID = 22958902 }}</ref>
*Rare YAP1 fusions in a subset of pediatric meningioma (HIPPO pathyway).<ref>{{Cite journal  | last1 = Sievers | first1 = P. | last2 = Chiang | first2 = J. | last3 = Schrimpf | first3 = D. | last4 = Stichel | first4 = D. | last5 = Paramasivam | first5 = N. | last6 = Sill | first6 = M. | last7 = Gayden | first7 = T. | last8 = Casalini | first8 = B. | last9 = Reuss | first9 = DE. | title = YAP1-fusions in pediatric NF2-wildtype meningioma. | journal = Acta Neuropathol | volume =  | issue =  | pages =  | month = Nov | year = 2019 | doi = 10.1007/s00401-019-02095-9 | PMID = 31734728 }}</ref>
 
Methylation profiling distinguishes two major groups with six distinct clinically relevant methylation classes.<ref>{{Cite journal  | last1 = Sahm | first1 = F. | last2 = Schrimpf | first2 = D. | last3 = Stichel | first3 = D. | last4 = Jones | first4 = DT. | last5 = Hielscher | first5 = T. | last6 = Schefzyk | first6 = S. | last7 = Okonechnikov | first7 = K. | last8 = Koelsche | first8 = C. | last9 = Reuss | first9 = DE. | title = DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. | journal = Lancet Oncol | volume =  | issue =  | pages =  | month = Mar | year = 2017 | doi = 10.1016/S1470-2045(17)30155-9 | PMID = 28314689 }}</ref>
 
 


===DDx of meningioma & IHC<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref>===
===DDx of meningioma & IHC<ref name=pmid16393681>{{cite journal |author=Hahn HP, Bundock EA, Hornick JL |title=Immunohistochemical staining for claudin-1 can help distinguish meningiomas from histologic mimics |journal=Am. J. Clin. Pathol. |volume=125 |issue=2 |pages=203–8 |year=2006 |month=February |pmid=16393681 |doi=10.1309/G659-FVVB-MG7U-4RPQ |url=http://ajcp.ascpjournals.org/content/125/2/203.full.pdf}}</ref>===
*S-100 +ve - [[schwannoma]].
*S-100 strong +ve - [[schwannoma]].
**+ve in ~80% of fibrous meningiomas.
**+ve in ~80% of fibrous meningiomas.
*CD34 +ve - solitary fibrous tumour.
*CD34 +ve - [[solitary fibrous tumour]].
**+ve in ~60% of fibrous meningiomas.
**+ve in ~60% of [[fibrous meningioma]]s.
*EMA +ve in ~30% of hemangiopericytoma.
*STAT6 nuclear +ve: [[solitary fibrous tumour]].
*[[EMA]] +ve in ~30% of [[solitary fibrous tumour]]/[[hemangiopericytoma]].
*Claudin-1 - new kid on the block: +ve in meningioma, but low [[sensitivity]].
*Claudin-1 - new kid on the block: +ve in meningioma, but low [[sensitivity]].
*SSTR2A +ve in meningioma, usu. -ve in [[Perineurioma]] <ref>{{Cite journal  | last1 = Agaimy | first1 = A. | last2 = Buslei | first2 = R. | last3 = Coras | first3 = R. | last4 = Rubin | first4 = BP. | last5 = Mentzel | first5 = T. | title = Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. | journal = Histopathology | volume = 65 | issue = 1 | pages = 60-70 | month = Jul | year = 2014 | doi = 10.1111/his.12366 | PMID = 24393170 }}</ref>
* Progesterone receptor: +ve in mostly grade I and meningeothelial tumors.<ref>{{Cite journal  | last1 = Grunberg | first1 = SM. | title = The role of progesterone receptors in meningioma. | journal = Cancer Treat Res | volume = 58 | issue =  | pages = 127-37 | month =  | year = 1991 | doi =  | PMID = 1683782 }}</ref>
* [[Pulmonary meningothelial-like nodule]]


===Standard work-up (UHN)<ref>Croul, SE. 8 November 2010.</ref>===
===A standard work-up===
*Ki-67 >5-10% - predicts re-occurrence.
*Ki-67 >5-10% - predicts re-occurrence.<ref>Croul, SE. 8 November 2010.</ref>
*PR (progesterone receptor) +ve in 2/3; -ve PR predicts re-occurrence.
*PR (progesterone receptor) +ve in > 80% of meningiomas.<ref>{{Cite journal  | last1 = Takei | first1 = H. | last2 = Buckleair | first2 = LW. | last3 = Powell | first3 = SZ. | title = Immunohistochemical expression of apoptosis regulating proteins and sex hormone receptors in meningiomas. | journal = Neuropathology | volume = 28 | issue = 1 | pages = 62-8 | month = Feb | year = 2008 | doi = 10.1111/j.1440-1789.2007.00852.x | PMID = 18021195 }}</ref>
**Loss of PR staining predicts recurrence.
**Strong association with tumour grade:<ref name=pmid22616825>{{Cite journal  | last1 = Tao | first1 = Y. | last2 = Liang | first2 = G. | last3 = Li | first3 = Z. | last4 = Wang | first4 = Y. | last5 = Wu | first5 = A. | last6 = Wang | first6 = H. | last7 = Lu | first7 = Y. | last8 = Liu | first8 = Z. | last9 = Hu | first9 = G. | title = Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse. | journal = Br J Neurosurg | volume =  | issue =  | pages =  | month = May | year = 2012 | doi = 10.3109/02688697.2012.685780 | PMID = 22616825 }}</ref> 
***Low WHO grade tumours usu. +ve.
***High WHO grade tumours usu. -ve.


==See also==
==See also==
Line 174: Line 420:
*[[Neurohistology]].
*[[Neurohistology]].
*[[CNS tumours]].
*[[CNS tumours]].
*[[Pulmonary meningothelial-like nodule]].


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


==External links==
*[http://www.medscape.com/viewarticle/566365_2 Histopathology review of meningioma (medscape.com)].


[[Category:Neuropathology]]
[[Category:Neuropathology tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]
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