Difference between revisions of "Melanotic Xp11 translocation renal cancer"
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*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
*[[Xp11.2 translocation carcinoma]]. | *[[Xp11.2 translocation carcinoma]]. | ||
===Images=== | |||
<gallery> | |||
Image: Melanotic Xp11.2 translocation renal cancer -- low mag.jpg | MXTRC - low mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer -- intermed mag.jpg | MXTRC - intermed. mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer -- high mag.jpg | MXTRC - high mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer -- very high mag.jpg | MXTRC - very high mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer - b -- low mag.jpg | MXTRC - low mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer - b -- intermed mag.jpg | MXTRC - intermed. mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer - b1 -- high mag.jpg | MXTRC - high mag. | |||
Image: Melanotic Xp11.2 translocation renal cancer - b2 -- high mag.jpg | MXTRC - high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Revision as of 05:11, 2 January 2018
Melanotic Xp11 translocation renal cancer is a very rare kidney tumour that is evolving as an entity.[1]
General
Microscopic
Features:
- Melanin-like pigment.
- Clear cells, epithelioid morphology - similar to Xp11.2 translocation carcinoma.
DDx:
- PEComa - may have TFE3 rearrangement.
- Malignant melanoma.
- Xp11.2 translocation carcinoma.
Images
MXTRC - low mag.
MXTRC - intermed. mag.
MXTRC - high mag.
MXTRC - very high mag.
MXTRC - low mag.
MXTRC - intermed. mag.
MXTRC - high mag.
MXTRC - high mag.
IHC
- TFE3 +ve.
- Keratin -ve.
Molecular
- TFE3 rearrangement.
See also
References
- ↑ 1.0 1.1 Rao, Q.; Shen, Q.; Xia, QY.; Wang, ZY.; Liu, B.; Shi, SS.; Shi, QL.; Yin, HL. et al. (Sep 2015). "PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity.". Am J Surg Pathol 39 (9): 1181-96. doi:10.1097/PAS.0000000000000502. PMID 26274027.
- ↑ Argani, P.; Aulmann, S.; Karanjawala, Z.; Fraser, RB.; Ladanyi, M.; Rodriguez, MM. (Apr 2009). "Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma.". Am J Surg Pathol 33 (4): 609-19. doi:10.1097/PAS.0b013e31818fbdff. PMID 19065101.