Difference between revisions of "Medulloblastoma"

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770 bytes added ,  14:26, 21 September 2017
→‎Subtypes: SHH subgroups
(→‎Subtypes: prognosis)
(→‎Subtypes: SHH subgroups)
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==Subtypes==
==Subtypes==
===Histologically defined===
*Classic medulloblastoma (~85% of all medulloblastomas).
*Classic medulloblastoma (~85% of all medulloblastomas).
*Variants of medulloblastoma (~15% of all medulloblastomas together):
*Variants of medulloblastoma (~15% of all medulloblastomas together):
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*#Desmoplastic/nodular medulloblastoma (DNMB).
*#Desmoplastic/nodular medulloblastoma (DNMB).
*#Medulloblastoma with extensive nodularity (MBEN).
*#Medulloblastoma with extensive nodularity (MBEN).


====Anaplastic variant====
====Anaplastic variant====
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*Polygonal cells.
*Polygonal cells.


 
===Genetically defined===
*WNT
*SHH
**infantile and adult cases are biologically different, esp p53 mutant tumors are associated with poor outcome.<ref>{{Cite journal  | last1 = Kool | first1 = M. | last2 = Jones | first2 = DT. | last3 = Jäger | first3 = N. | last4 = Northcott | first4 = PA. | last5 = Pugh | first5 = TJ. | last6 = Hovestadt | first6 = V. | last7 = Piro | first7 = RM. | last8 = Esparza | first8 = LA. | last9 = Markant | first9 = SL. | title = Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. | journal = Cancer Cell | volume = 25 | issue = 3 | pages = 393-405 | month = Mar | year = 2014 | doi = 10.1016/j.ccr.2014.02.004 | PMID = 24651015 }}</ref>
*Group 3
*Group 4


==Prognosis==
==Prognosis==
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