Difference between revisions of "Medulloblastoma"
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Jensflorian (talk | contribs) (→Subtypes: prognosis) |
Jensflorian (talk | contribs) (→Subtypes: SHH subgroups) |
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==Subtypes== | ==Subtypes== | ||
===Histologically defined=== | |||
*Classic medulloblastoma (~85% of all medulloblastomas). | *Classic medulloblastoma (~85% of all medulloblastomas). | ||
*Variants of medulloblastoma (~15% of all medulloblastomas together): | *Variants of medulloblastoma (~15% of all medulloblastomas together): | ||
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*#Desmoplastic/nodular medulloblastoma (DNMB). | *#Desmoplastic/nodular medulloblastoma (DNMB). | ||
*#Medulloblastoma with extensive nodularity (MBEN). | *#Medulloblastoma with extensive nodularity (MBEN). | ||
====Anaplastic variant==== | ====Anaplastic variant==== | ||
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*Polygonal cells. | *Polygonal cells. | ||
===Genetically defined=== | |||
*WNT | |||
*SHH | |||
**infantile and adult cases are biologically different, esp p53 mutant tumors are associated with poor outcome.<ref>{{Cite journal | last1 = Kool | first1 = M. | last2 = Jones | first2 = DT. | last3 = Jäger | first3 = N. | last4 = Northcott | first4 = PA. | last5 = Pugh | first5 = TJ. | last6 = Hovestadt | first6 = V. | last7 = Piro | first7 = RM. | last8 = Esparza | first8 = LA. | last9 = Markant | first9 = SL. | title = Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. | journal = Cancer Cell | volume = 25 | issue = 3 | pages = 393-405 | month = Mar | year = 2014 | doi = 10.1016/j.ccr.2014.02.004 | PMID = 24651015 }}</ref> | |||
*Group 3 | |||
*Group 4 | |||
==Prognosis== | ==Prognosis== | ||