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Difference between revisions of "Medullary colorectal carcinoma"
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DDx: | DDx: | ||
*Other (poorly differentiated) [[colorectal carcinoma]]s. | *Other (poorly differentiated) [[colorectal carcinoma]]s. | ||
**Colorectal cancer with loss of [[SMARCB1]] expression.<ref name=pmid32083567/> | |||
*Carcinomas with neuroendocrine differentiation. | *Carcinomas with neuroendocrine differentiation. | ||
*[[Lymphoepithelioma-like carcinoma]] of the colon.<ref>{{cite journal |authors=Delaney D, Chetty R |title=Lymphoepithelioma-like carcinoma of the colon |journal=Int J Clin Exp Pathol |volume=5 |issue=1 |pages=105–9 |date=2012 |pmid=22295155 |pmc=3267494 |doi= |url=}}</ref> | *[[Lymphoepithelioma-like carcinoma]] of the colon.<ref>{{cite journal |authors=Delaney D, Chetty R |title=Lymphoepithelioma-like carcinoma of the colon |journal=Int J Clin Exp Pathol |volume=5 |issue=1 |pages=105–9 |date=2012 |pmid=22295155 |pmc=3267494 |doi= |url=}}</ref> | ||
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*Calretinin (67%-73%)<ref>{{cite journal |authors=Winn B, Tavares R, Fanion J, Noble L, Gao J, Sabo E, Resnick MB |title=Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation |journal=Hum. Pathol. |volume=40 |issue=3 |pages=398–404 |date=March 2009 |pmid=18992917 |pmc=2657293 |doi=10.1016/j.humpath.2008.08.014 |url=}}</ref><ref>{{cite journal |authors=Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, Wang HL, Liu H |title=Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine |journal=Arch. Pathol. Lab. Med. |volume=138 |issue=8 |pages=1015–26 |date=August 2014 |pmid=24437456 |doi=10.5858/arpa.2013-0452-OA |url=}}</ref> | *Calretinin (67%-73%)<ref>{{cite journal |authors=Winn B, Tavares R, Fanion J, Noble L, Gao J, Sabo E, Resnick MB |title=Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation |journal=Hum. Pathol. |volume=40 |issue=3 |pages=398–404 |date=March 2009 |pmid=18992917 |pmc=2657293 |doi=10.1016/j.humpath.2008.08.014 |url=}}</ref><ref>{{cite journal |authors=Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, Wang HL, Liu H |title=Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine |journal=Arch. Pathol. Lab. Med. |volume=138 |issue=8 |pages=1015–26 |date=August 2014 |pmid=24437456 |doi=10.5858/arpa.2013-0452-OA |url=}}</ref> | ||
Notes: | |||
*CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma. | *CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma. | ||
*SMARCB1 loss - reported in one case.<ref name=pmid32083567>{{cite journal |authors=Melloul S, Mosnier JF, Masliah-Planchon J, Lepage C, Le Malicot K, Gornet JM, Edeline J, Dansette D, Texereau P, Delattre O, Laurent Puig P, Taieb J, Emile JF |title=Loss of SMARCB1 expression in colon carcinoma |journal=Cancer Biomark |volume=27 |issue=3 |pages=399–406 |date=2020 |pmid=32083567 |doi=10.3233/CBM-190287 |url=}}</ref> | |||
==See also== | ==See also== | ||