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Difference between revisions of "Medical kidney diseases"
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→Focal segmental glomerulosclerosis: primary vs. secondary
(→Membranous nephropathy: +schematic image) |
(→Focal segmental glomerulosclerosis: primary vs. secondary) |
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| Line 420: | Line 420: | ||
*Does not respond to steroids (unlike MCD). | *Does not respond to steroids (unlike MCD). | ||
Etiology | ====Etiology==== | ||
*Primary. | *Primary. | ||
**May be familial.<ref name=pmid12778884>{{cite journal |author=Sánchez de la Nieta MD, Arias LF, Alcázar R, ''et al.'' |title=[Familial focal and segmentary hyalinosis] |language=Spanish; Castilian |journal=Nefrologia |volume=23 |issue=2 |pages=172–6 |year=2003 |pmid=12778884 |doi= |url=}}</ref> | **May be familial.<ref name=pmid12778884>{{cite journal |author=Sánchez de la Nieta MD, Arias LF, Alcázar R, ''et al.'' |title=[Familial focal and segmentary hyalinosis] |language=Spanish; Castilian |journal=Nefrologia |volume=23 |issue=2 |pages=172–6 |year=2003 |pmid=12778884 |doi= |url=}}</ref> | ||
| Line 427: | Line 427: | ||
**Drug use. | **Drug use. | ||
**Reduced renal mass. | **Reduced renal mass. | ||
Primary vs. secondary:<ref name=pmid12704572>{{Cite journal | last1 = D'Agati | first1 = V. | title = Pathologic classification of focal segmental glomerulosclerosis. | journal = Semin Nephrol | volume = 23 | issue = 2 | pages = 117-34 | month = Mar | year = 2003 | doi = 10.1053/snep.2003.50012 | PMID = 12704572 }} | |||
</ref> | |||
{| class="wikitable" | |||
| '''Feature''' | |||
| '''Primary''' | |||
| '''Secondary''' | |||
|- | |||
| Proteinuria (onset) | |||
| sudden | |||
| progressive | |||
|- | |||
| Albumnin | |||
| low | |||
| normal | |||
|- | |||
| Glomerulus size | |||
| normal | |||
| increased | |||
|- | |||
| Foot process effacement | |||
| diffuse | |||
| mild | |||
|} | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Partial sclerosis of | *Partial sclerosis of less than 50% of glomeruli. | ||
Image: | Image: | ||