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Difference between revisions of "Medical kidney diseases"
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Medical kidney diseases (view source)
Revision as of 14:00, 4 November 2011
, 14:00, 4 November 2011→Crescents: more
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*Lupus. | *Lupus. | ||
=== | ===Glomerular crescents=== | ||
* | *[[AKA]] crescents. | ||
====General==== | |||
*Indicates a rapidly progressive disease. | |||
*Etiology/definition: break in the glomerular basement membrane (GBM). | *Etiology/definition: break in the glomerular basement membrane (GBM). | ||
Microscopic | ====Microscopic==== | ||
*Crescentic-shaped lesion in the urinary space of a glomerulus. | |||
**Crescent = looks like the moon shortly after new moon. | |||
*Break in the glomerular basement membrane - '''key feature'''. | *Break in the glomerular basement membrane - '''key feature'''. | ||
**Best seen on a silver stain (e.g. [[Jones stain]]). | **Best seen on a silver stain (e.g. [[Jones stain]]). | ||
*Fibrin. | *Fibrin. | ||
**Described as orange on [[HPS stain|HPS]]. | **Described as orange on [[HPS stain|HPS]]. | ||
* | *Urinary space cellular debris. | ||
*Inflammatory cells (lymphocytes, plasma cells, eosinophils, macrophages). | *Inflammatory cells (lymphocytes, plasma cells, eosinophils, macrophages) - extravascular - '''low power''' feature. | ||
DDx: | |||
*Glomerular sclerosis: | |||
**Usu. no significant inflammation. | |||
**No fibrin. | |||
**Collagen deposition within the glomerular tuft. | |||
***Seen with [[trichrome stain]]. | |||
====Bland necrotic crescents==== | ====Bland necrotic crescents==== | ||