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Difference between revisions of "Mastocytosis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Mastocytosis_-_cropped_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Mastocytosis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = mast cells (cells in the superficial/mid dermis that are: lymphocyte-like with more cytoplasm that is granular; cells may have spindled or stellate morphology); +/-eosinophils (common) | |||
| Subtypes = | |||
| LMDDx = [[intradermal nevus]] | |||
| Stains = [[Giemsa stain]] +ve | |||
| IHC = CD117 +ve, tryptase +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = not very common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = dependent on underlying cause | |||
| Other = | |||
| ClinDDx = | |||
| Tx = dependent on underlying cause | |||
}} | |||
'''Mastocytosis''' is the abundance of [[mast cells]]. It can be due to a number of causes. | '''Mastocytosis''' is the abundance of [[mast cells]]. It can be due to a number of causes. | ||
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Notes: | Notes: | ||
*Lymphocyte | *Lymphocyte versus mast cell: | ||
**Lymphocytes = round; mast cells = ovoid. | **Lymphocytes = round; mast cells = ovoid. | ||
DDx: | |||
*[[Intradermal nevus]]. | |||
*[[Pleomorphic undifferentiated sarcoma]], [[Langerhans cell histiocytosis]] and other [[pleomorphic tumours]] - for ''aggressive systemic mastocytosis''. | |||
===Images=== | ===Images=== | ||
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*[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case409.html Systemic mastocytosis - several images (upmc.edu)]. | ||
<gallery> | <gallery> | ||
Image:Mastocytosis - intermed mag.jpg | Mastocytosis - intermed. mag. (WC) | |||
Image:Mastocytosis_-_high_mag.jpg | Mastocytosis - high mag. (WC) | Image:Mastocytosis_-_high_mag.jpg | Mastocytosis - high mag. (WC) | ||
Image:Mastocytosis_-_very_high_mag.jpg | Mastocytosis - very high mag. (WC) | |||
Image:Mastocytosis_-_cropped_-_very_high_mag.jpg | Mastocytosis - very high mag. (WC) | Image:Mastocytosis_-_cropped_-_very_high_mag.jpg | Mastocytosis - very high mag. (WC) | ||
</gallery> | </gallery> | ||
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==Stains== | ==Stains== | ||
*[[Toluidine blue stain|Toluidine blue]] -- highlights the granules. | *[[Toluidine blue stain|Toluidine blue]] -- highlights the granules. | ||
*[[Giemsa stain]] +ve | |||
==IHC== | ==IHC== | ||