Difference between revisions of "Mast cell"

From Libre Pathology
Jump to navigation Jump to search
 
(2 intermediate revisions by the same user not shown)
Line 30: Line 30:
*[[Neurofibroma]].
*[[Neurofibroma]].
*[[Melanocytic nevi]].<ref name=pmid8432898>{{Cite journal  | last1 = Carr | first1 = NJ. | last2 = Warren | first2 = AY. | title = Mast cell numbers in melanocytic naevi and cutaneous neurofibromas. | journal = J Clin Pathol | volume = 46 | issue = 1 | pages = 86-7 | month = Jan | year = 1993 | doi =  | PMID = 8432898 }}</ref>
*[[Melanocytic nevi]].<ref name=pmid8432898>{{Cite journal  | last1 = Carr | first1 = NJ. | last2 = Warren | first2 = AY. | title = Mast cell numbers in melanocytic naevi and cutaneous neurofibromas. | journal = J Clin Pathol | volume = 46 | issue = 1 | pages = 86-7 | month = Jan | year = 1993 | doi =  | PMID = 8432898 }}</ref>
*[[Succinate dehydrogenase-deficient renal cell carcinoma]].<ref name=pmid25034258>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Eble | first2 = JN. | last3 = Amin | first3 = MB. | last4 = Gupta | first4 = NS. | last5 = Smith | first5 = SC. | last6 = Sholl | first6 = LM. | last7 = Montironi | first7 = R. | last8 = Hirsch | first8 = MS. | last9 = Hornick | first9 = JL. | title = Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. | journal = Mod Pathol | volume =  | issue =  | pages =  | month = Jul | year = 2014 | doi = 10.1038/modpathol.2014.86 | PMID = 25034258 }}</ref>


==Stains==
==Stains==
Line 36: Line 37:


==IHC==
==IHC==
*CD117 +ve.
*CD117 +ve.<ref name=pmid25038510>{{Cite journal  | last1 = Schmetzer | first1 = O. | last2 = Valentin | first2 = P. | last3 = Smorodchenko | first3 = A. | last4 = Domenis | first4 = R. | last5 = Gri | first5 = G. | last6 = Siebenhaar | first6 = F. | last7 = Metz | first7 = M. | last8 = Maurer | first8 = M. | title = A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs). | journal = J Immunol Methods | volume =  | issue =  | pages =  | month = Jul | year = 2014 | doi = 10.1016/j.jim.2014.07.003 | PMID = 25038510 }}</ref>
*CD34 +ve.<ref name=pmid22119830>{{Cite journal  | last1 = Duşe | first1 = AO. | last2 = Ceauşu | first2 = RA. | last3 = Mezei | first3 = T. | last4 = Cîmpean | first4 = AM. | last5 = Gaje | first5 = P. | last6 = Ioniţă | first6 = H. | last7 = Jung | first7 = I. | title = Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density. | journal = Rom J Morphol Embryol | volume = 52 | issue = 3 Suppl | pages = 1091-6 | month =  | year = 2011 | doi =  | PMID = 22119830 }}</ref>{{fact}}
*CD34 +ve.<ref name=pmid22119830>{{Cite journal  | last1 = Duşe | first1 = AO. | last2 = Ceauşu | first2 = RA. | last3 = Mezei | first3 = T. | last4 = Cîmpean | first4 = AM. | last5 = Gaje | first5 = P. | last6 = Ioniţă | first6 = H. | last7 = Jung | first7 = I. | title = Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density. | journal = Rom J Morphol Embryol | volume = 52 | issue = 3 Suppl | pages = 1091-6 | month =  | year = 2011 | doi =  | PMID = 22119830 }}</ref>{{fact}}



Latest revision as of 19:05, 27 October 2014

Mast cells in mastocytosis. H&E stain.

The mast cell is an uncommonly cell that occasionally causes problems.

Microscopic

Features:

  • Ovoid/round cell with moderate amount of gray granular cytoplasm.
  • Nuclear ovoid/round.
    • No obvious nucleolus.
  • May be more abundant around blood vessels.

Notes:

  • Lymphocyte vs. mast cell:
    • Lymphocytes = round; mast cells = ovoid.

Images

www:

Diseases

Conditions associated with the presence of mast cells

Stains

IHC

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.
  2. Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.
  3. Williamson, SR.; Eble, JN.; Amin, MB.; Gupta, NS.; Smith, SC.; Sholl, LM.; Montironi, R.; Hirsch, MS. et al. (Jul 2014). "Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma.". Mod Pathol. doi:10.1038/modpathol.2014.86. PMID 25034258.
  4. URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.
  5. Schmetzer, O.; Valentin, P.; Smorodchenko, A.; Domenis, R.; Gri, G.; Siebenhaar, F.; Metz, M.; Maurer, M. (Jul 2014). "A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs).". J Immunol Methods. doi:10.1016/j.jim.2014.07.003. PMID 25038510.
  6. Duşe, AO.; Ceauşu, RA.; Mezei, T.; Cîmpean, AM.; Gaje, P.; Ioniţă, H.; Jung, I. (2011). "Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.". Rom J Morphol Embryol 52 (3 Suppl): 1091-6. PMID 22119830.