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Difference between revisions of "Mammary myofibroblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Mammary myofibroblastoma - extra - very high mag.jpg | |||
| Width = | |||
| Caption = Mammary myofibroblastoma. [[H&E stain]]. | |||
| Synonyms = myofibroblastoma of the breast, breast myofibroblastoma | |||
| Micro = well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen. | |||
| Subtypes = | |||
| LMDDx = [[metaplastic breast carcinoma]], [[fibromatosis]], [[leiomyoma]] of the breast, [[nodular fasciitis]], [[phyllodes tumour]], [[spindle cell lipoma]] | |||
| Stains = | |||
| IHC = CD34 +ve, SMA +ve, desmin, +ve, vimentin +ve, S-100 -ve, beta-catenin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = postmenopausal female or older male | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = excision | |||
}} | |||
'''Mammary myofibroblastoma''', also '''myofibroblastoma of the breast''', is a rare benign pathology of the [[breast]]. | |||
==General== | |||
*Rare. | |||
*Excision = cure. | |||
*Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month = | year = | doi = | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/}}</ref> | |||
Note: | |||
*In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi = | PMID = 11474286 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref> | |||
*Well-circumscribed lesion. | |||
*Spindle cells without nuclear atypia arranged in fascicles. | |||
*Interspersed thick bundles of collagen. | |||
Notes: | |||
*No calcifications. | |||
*No necrosis. | |||
*No hemorrhage. | |||
DDx: | |||
*[[Metaplastic breast carcinoma]].<ref name=pmid24298520/> | |||
*[[Fibromatosis]]. | |||
*[[Leiomyoma]] of the breast. | |||
*[[Nodular fasciitis]]. | |||
*[[Phyllodes tumour]]. | |||
*[[Spindle cell lipoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron) | |||
Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron) | |||
Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref name=pmid22096693>{{Cite journal | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month = | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/}}</ref> | |||
*CD34 +ve.<ref name=pmid11474286/> | |||
*Desmin +ve.<ref name=pmid11474286/> | |||
*Actin +ve. | |||
*Vimentin +ve. | |||
*SMA +ve.<ref name=pmid24466766/> | |||
Others: | |||
*S-100 -ve.<ref name=pmid24298520/> | |||
*Beta-catenin -ve.{{fact}} | |||
*H-caldesmon -ve.<ref name=pmid24466766>{{Cite journal | last1 = Mnif | first1 = H. | last2 = Charfi | first2 = S. | last3 = Abid | first3 = N. | last4 = Sallemi-Boudawara | first4 = T. | title = Mammary myofibroblastoma with leiomyomatous differentiation: case report and literature review. | journal = Pathologica | volume = 105 | issue = 4 | pages = 142-5 | month = Aug | year = 2013 | doi = | PMID = 24466766 }}</ref>{{fact}} | |||
*CK7 -ve.<ref name=pmid24298520>{{Cite journal | last1 = Shivali | first1 = B. | last2 = S | first2 = K. | last3 = Chandramouleeswari | first3 = K. | last4 = Anita | first4 = S. | title = Myofibroblastoma breast with unusual morphological features. Cytohistopathogical diagnostic pitfalls and role of immunohistochemistry-review of literature. | journal = J Clin Diagn Res | volume = 7 | issue = 10 | pages = 2323-5 | month = Oct | year = 2013 | doi = 10.7860/JCDR/2013/5281.3515 | PMID = 24298520 }}</ref> | |||
*HMCK -ve.<ref name=pmid24298520/> | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Breast pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||