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Difference between revisions of "Malignant mesothelioma"
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→Microscopic
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Features:<ref name=Ref_WMSP156>{{Ref WMSP|156}}</ref> | Features:<ref name=Ref_WMSP156>{{Ref WMSP|156}}</ref> | ||
*Infiltrative atypical cells - '''key feature'''. | *Infiltrative atypical cells - '''key feature'''. | ||
**Infiltration into fat - ''diagnostic''. | |||
**+/-Epithelioid cells - may be cytologically bland, i.e. benign appearing. | **+/-Epithelioid cells - may be cytologically bland, i.e. benign appearing. | ||
***Variable architecture: sheets, microglandular, tubulopapillary. | ***Variable architecture: sheets, microglandular, tubulopapillary. | ||
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** Thin (asbestos) fiber in the core. | ** Thin (asbestos) fiber in the core. | ||
Notes: | |||
*''Asbestos body'' is not strictly speaking a synonym for ''ferruginous body''. | *''Asbestos body'' is not strictly speaking a synonym for ''ferruginous body''. | ||
*Don't diagnose ''mesothelioma in situ''.{{fact}} | |||
DDx:<ref name=pmid15559051>{{Cite journal | last1 = Corson | first1 = JM. | title = Pathology of mesothelioma. | journal = Thorac Surg Clin | volume = 14 | issue = 4 | pages = 447-60 | month = Nov | year = 2004 | doi = 10.1016/j.thorsurg.2004.06.007 | PMID = 15559051 }} | DDx:<ref name=pmid15559051>{{Cite journal | last1 = Corson | first1 = JM. | title = Pathology of mesothelioma. | journal = Thorac Surg Clin | volume = 14 | issue = 4 | pages = 447-60 | month = Nov | year = 2004 | doi = 10.1016/j.thorsurg.2004.06.007 | PMID = 15559051 }} | ||
</ref> | </ref> | ||
*[[Fibrosing pleuritis]]. | *[[Fibrosing pleuritis]] - should ''not'' have nodules, more cellular on the aspect adjacent to the effusion. | ||
*Reactive mesothelial cells - may be atypical. | |||
*Mesothelial hyperplasia. | *Mesothelial hyperplasia. | ||
*[[Adenocarcinoma]] - esp. [[lung adenocarcinoma]]. | *[[Adenocarcinoma]] - esp. [[lung adenocarcinoma]]. | ||