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Difference between revisions of "Malignant melanoma"
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→Breslow thickness
(→Skin) |
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*Depth measured from stratum granulosum to deepest intradermal tumour cell - predictive of survival.<ref name=Ref_PCPBoD8>{{Ref PCPBoD8|595}}</ref> | *Depth measured from stratum granulosum to deepest intradermal tumour cell - predictive of survival.<ref name=Ref_PCPBoD8>{{Ref PCPBoD8|595}}</ref> | ||
Melanoma staging is based on the Breslow thickness:<ref>{{Cite journal | last1 = Nowecki | first1 = ZI. | last2 = Rutkowski | first2 = P. | last3 = Michej | first3 = W. | title = The survival benefit to patients with positive sentinel node melanoma after completion lymph node dissection may be limited to the subgroup with a primary lesion Breslow thickness greater than 1.0 and less than or equal to 4 mm (pT2-pT3). | journal = Ann Surg Oncol | volume = 15 | issue = 8 | pages = 2223-34 | month = Aug | year = 2008 | doi = 10.1245/s10434-008-9965-3 | PMID = 18506535 }}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2013/SkinMelanoma_13protocol_3300.doc http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2013/SkinMelanoma_13protocol_3300.doc]. Accessed on: 2 January 2014.</ref> | =====Tumour stage===== | ||
Melanoma staging is based primarily on the Breslow thickness:<ref>{{Cite journal | last1 = Nowecki | first1 = ZI. | last2 = Rutkowski | first2 = P. | last3 = Michej | first3 = W. | title = The survival benefit to patients with positive sentinel node melanoma after completion lymph node dissection may be limited to the subgroup with a primary lesion Breslow thickness greater than 1.0 and less than or equal to 4 mm (pT2-pT3). | journal = Ann Surg Oncol | volume = 15 | issue = 8 | pages = 2223-34 | month = Aug | year = 2008 | doi = 10.1245/s10434-008-9965-3 | PMID = 18506535 }}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2013/SkinMelanoma_13protocol_3300.doc http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2013/SkinMelanoma_13protocol_3300.doc]. Accessed on: 2 January 2014.</ref> | |||
*pT1 <= 1.0 mm. | *pT1 <= 1.0 mm. | ||
**pT1a: no ulceration, <1 mitoses/mm<sup>2</sup>. | **pT1a: no ulceration, <1 mitoses/mm<sup>2</sup>. | ||
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=====Clark level===== | =====Clark level===== | ||
*[[AKA]] ''anatomic level''. | *[[AKA]] ''anatomic level''. | ||
*Not as reproducible as ''Breslow thickness'' | *''Not'' as reproducible as ''Breslow thickness''. It is not used for this reason. | ||
Anatomic level - definition: | Anatomic level - definition: | ||
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*IV = extends into reticular dermis. | *IV = extends into reticular dermis. | ||
*V = extends into subdermis. | *V = extends into subdermis. | ||
====Subtypes==== | ====Subtypes==== | ||