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Difference between revisions of "Lymphovascular invasion"
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'''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''. | '''Lymphovascular invasion''', also '''lymphovascular space invasion''', is (non-hematologic) malignant cells within [[blood vessels]] and/or lymphatics. It is abbreviated '''LVI'''. | ||
The term ''lymphovascular invasion'' is preferred to ''vascular invasion'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]]. | The term ''lymphovascular invasion'' is preferred to ''[[vascular invasion]]'', as it is very difficult to differentiate morphologically small lymphatics and small vascular spaces, without [[immunohistochemistry]]. | ||
==General== | ==General== | ||
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<gallery> | <gallery> | ||
Image:Merkel_cell_carcinoma_-_high_mag.jpg | Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron) | Image:Merkel_cell_carcinoma_-_high_mag.jpg | Small focus of LVI in a [[merkel cell carcinoma]]. (WC/Nephron) | ||
Image: | Image: Seminoma LVI -- low mag.jpg | [[LVI]] - low mag. (WC/Nephron) | ||
Image: Seminoma LVI -- intermed mag.jpg | LVI - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
<gallery> | |||
Image: CRC with LVI - HE -- very low mag.jpg | [[colorectal carcinoma|CRC]] with LVI - very low mag. (WC/Nephron) | |||
Image: CRC with LVI - HE -- low mag.jpg | CRC with LVI - low mag. (WC/Nephron) | |||
Image: CRC with LVI - HE -- intermed mag.jpg | CRC with LVI - intermed. mag. (WC/Nephron) | |||
Image: CRC with LVI - HE - alt -- high mag.jpg | CRC with LVI - high mag. (WC/Nephron) | |||
Image: CRC with LVI - HE -- very high mag.jpg | CRC with LVI - very high mag. (WC/Nephron) | |||
</gallery> | </gallery> | ||
==Stains== | ==Stains== | ||
*[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal | last1 = Howlett | first1 = CJ. | last2 = Tweedie | first2 = EJ. | last3 = Driman | first3 = DK. | title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. | journal = J Clin Pathol | volume = 62 | issue = 11 | pages = 1021-5 | month = Nov | year = 2009 | doi = 10.1136/jcp.2009.065615 | PMID = 19861561 }}</ref> | *[[Movat stain]] - especially useful in [[colorectal carcinoma]] so one can readily identify [[blood vessel]]s.<ref name=pmid19861561>{{Cite journal | last1 = Howlett | first1 = CJ. | last2 = Tweedie | first2 = EJ. | last3 = Driman | first3 = DK. | title = Use of an elastic stain to show venous invasion in colorectal carcinoma: a simple technique for detection of an important prognostic factor. | journal = J Clin Pathol | volume = 62 | issue = 11 | pages = 1021-5 | month = Nov | year = 2009 | doi = 10.1136/jcp.2009.065615 | PMID = 19861561 }}</ref> | ||
*[[ | *Elastin stain. | ||
===Images=== | |||
<gallery> | |||
Image: CRC with LVI - elastin -- very low mag.jpg | [[colorectal carcinoma|CRC]] with LVI - elastin - very low mag. (WC/Nephron) | |||
Image: CRC with LVI - elastin -- low mag.jpg | CRC with LVI - elastin - low mag. (WC/Nephron) | |||
Image: CRC with LVI - elastin -- intermed mag.jpg | CRC with LVI - elastin - intermed. mag. (WC/Nephron) | |||
Image: CRC with LVI - elastin - alt -- high mag.jpg | CRC with LVI - elastin - high mag. (WC/Nephron) | |||
Image: CRC with LVI - elastin -- very high mag.jpg | CRC with LVI - elastin - very high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
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*[[Intravascular lymphoma]]. | *[[Intravascular lymphoma]]. | ||
*[[Perineural invasion]]. | *[[Perineural invasion]]. | ||
*[[Angioinvasion]]. | |||
*[[MELF]]. | |||
==References== | ==References== | ||