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| | [[Image:Lymphoma macro.jpg | thumb | 200px | right | Lymphoma at [[cut-up]]. (WC/Emmanuelm)]] |
| '''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways. | | '''Lymphoma''' is almost a specialty for itself. It can be subclassified a number of ways. |
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| ====Histologic terms==== | | ====Histologic terms==== |
| *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. | | *Lymphomas = cells look discohesive, may be difficult to differentiate from poor differentiated carcinoma. |
| *Auer rods = Acute myeloid leukemia. | | *[[Auer rods]] = [[acute myeloid leukemia]]. |
| **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). | | **Granular cytoplasmic rod (0.5-1 x4-6 micrometres). |
| | **Not pathognomonic. |
| *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. | | *Reed-Sternberg cells = [[Hodgkin's lymphoma]]. |
| **Large cell - very large nucleus. | | **Large cell - very large nucleus. |
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| Others: | | Others: |
| *AE1/AE3 -- to r/o carcinoma. | | *[[AE1/AE3]] -ve -- to r/o carcinoma. |
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| ====T cell markers==== | | ====T cell markers==== |
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| ==Intravascular lymphoma== | | ==Intravascular lymphoma== |
| | *[[AKA]] ''angiotropic lymphoma'', ''intravascular malignant lymphomatosis'', ''malignant angioendotheliomatosis'' |
| *Rare. | | *Rare. |
| *Usually B-cell lineage (see below ''intravascular large B-cell lymphoma''). | | *Usually B-cell lineage (see ''[[intravascular large B-cell lymphoma]]''). |
| **May be T-cell lineage.<ref name=pmid20337769>{{cite journal |author=Wang L, Li C, Gao T |title=Cutaneous intravascular anaplastic large cell lymphoma |journal=J Cutan Pathol |volume= |issue= |pages= |year=2010 |month=March |pmid=20337769 |doi=10.1111/j.1600-0560.2010.01538.x |url=}}</ref> | | **May be T-cell lineage.<ref name=pmid20337769>{{cite journal |author=Wang L, Li C, Gao T |title=Cutaneous intravascular anaplastic large cell lymphoma |journal=J Cutan Pathol |volume= |issue= |pages= |year=2010 |month=March |pmid=20337769 |doi=10.1111/j.1600-0560.2010.01538.x |url=}}</ref> |
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| ===Intravascular large B-cell lymphoma===
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| ====General====
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| *[[AKA]] ''angiotropic lymphoma'', ''intravascular malignant lymphomatosis'', ''malignant angioendotheliomatosis''.
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| =====Clinical=====
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| *Often a non-specific presentation.<ref name=pmid11579120>{{cite journal |author=Lapkuviene O, Forchetti D, Roepke JE |title=Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms |journal=J. Clin. Oncol. |volume=19 |issue=19 |pages=3988–91 |year=2001 |month=October |pmid=11579120 |doi= |url=http://jco.ascopubs.org/content/19/19/3988.full}}</ref>
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| **+/-Fever.
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| **+/-Multiple infarcts.
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| **+/-Non-specific skin lesions.
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| ====Microscopic====
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| Features:
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| *Abundant atypical intravascular lymphoid cells that are:
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| **Large (~2-3X size of a mature lymphocyte or RBC).
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| **Nucleolus prominent.
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| Notes:
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| *It may be hard to find RBCs in the vessels.
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| *Looks sorta like a [[DLBCL]] -- but is intravascular.
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| =====Images=====
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| <gallery>
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| Image:Intravascular_lymphoma_-_high_mag.jpg | Intravascular lymphoma - high mag. (WC/Nephron)
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| Image:Intravascular_lymphoma_-_very_high_mag.jpg | Intravascular lymphoma - very high mag. (WC/Nephron)
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| </gallery>
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| www:
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| *[http://jco.ascopubs.org/content/19/19/3988/F1.expansion.html ILBCL (ascopubs.org)].<ref name=pmid11579120/>
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| *[http://theoncologist.alphamedpress.org/cgi/content/full/11/8/923/F1 ILBCL in bone marrow (alphamedpress.org)].
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| *[http://annonc.oxfordjournals.org/content/13/9/1503/F1.expansion.html ILBCL - various images (oxfordjournals.org)].
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| *[http://path.upmc.edu/cases/case473/images/fig01a.jpg ILBCL (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case473.html http://path.upmc.edu/cases/case473.html]. Accessed on: 21 January 2012.</ref>
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| *[http://path.upmc.edu/cases/case697.html ILBCL - several images (upmc.edu)].
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| ====IHC====
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| Features:<ref name=pmid11579120/>
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| *CD20 +ve - '''key feature'''.
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| *CD3 -ve.
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| *CD34 -ve.
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| ==Burkitt's lymphoma== | | ==Burkitt's lymphoma== |
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| Features: | | Features: |
| *Intermediate size cells with: | | *Intermediate size cells with: |
| **+/-Vesicular nuclei. | | **+/-[[Vesicular nuclei]]. |
| **Clear, moderate cytoplasm. | | **Clear, moderate cytoplasm. |
| *"Empty" sinus; subcapsular sinuses "open". | | *"Empty" sinus; subcapsular sinuses "open". |
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| *[[AKA]] ''extranodal natural kill lymphoma'' | | *[[AKA]] ''extranodal natural kill lymphoma'' |
| *[[AKA]] ''angiocentric lymphoma''. | | *[[AKA]] ''angiocentric lymphoma''. |
| | | {{Main|Extranodal NK/T-cell lymphoma, nasal type}} |
| ===General===
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| *Common in east Asia.<ref name=pmid18283711>{{Cite journal | last1 = Suzuki | first1 = R. | last2 = Takeuchi | first2 = K. | last3 = Ohshima | first3 = K. | last4 = Nakamura | first4 = S. | title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. | journal = Hematol Oncol | volume = 26 | issue = 2 | pages = 66-72 | month = Jun | year = 2008 | doi = 10.1002/hon.847 | PMID = 18283711 }}</ref>
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| *Strong association with [[EBV]].
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| ===Microscopic===
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| Features:
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| *Atypical lymphoid cells:
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| **[[Nucleoli]].
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| **[[Nuclear pleomorphism]].
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| **Cells centered around vessels (angiocentric).
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| ***May destroy small and medium sized arterioles.
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| Images:
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| *[http://path.upmc.edu/cases/case231/micro.html Extranodal NK/T-cell lymphoma, nasal type - case 1 - several images (upmc.edu)].
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| *[http://path.upmc.edu/cases/case310.html Extranodal NK/T-cell lymphoma, nasal type - case 2 - several images (upmc.edu)].
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| ===IHC===
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| Features:<ref name=pmid17064952>{{Cite journal | last1 = Al-Hakeem | first1 = DA. | last2 = Fedele | first2 = S. | last3 = Carlos | first3 = R. | last4 = Porter | first4 = S. | title = Extranodal NK/T-cell lymphoma, nasal type. | journal = Oral Oncol | volume = 43 | issue = 1 | pages = 4-14 | month = Jan | year = 2007 | doi = 10.1016/j.oraloncology.2006.03.011 | PMID = 17064952 }}</ref>
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| *CD2 +ve.
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| *CD3 +ve (cytoplasmic).
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| *CD56 +ve.
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| Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>
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| *TIA-1 +ve.
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| *CD7 +ve.
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| *EBER +ve.
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| ==Table of lymphoma== | | ==Table of lymphoma== |