Difference between revisions of "Lymphoepithelioma-like carcinoma"

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==General==
==General==
It is thought to be related to ''[[nasopharyngeal carcinoma]]'' ([[AKA]] lymphoepithelioma).<ref name=pmid17347662>{{Cite journal  | last1 = Mayer | first1 = EK. | last2 = Beckley | first2 = I. | last3 = Winkler | first3 = MH. | title = Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications. | journal = Nat Clin Pract Urol | volume = 4 | issue = 3 | pages = 167-71 | month = Mar | year = 2007 | doi = 10.1038/ncpuro0725 | PMID = 17347662 }}</ref><ref name=dermcdlib_lelc>URL: [http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html]. Accessed on: 11 May 2011.</ref>
It is thought to be related to ''[[nasopharyngeal carcinoma]]'' ([[AKA]] lymphoepithelioma).<ref name=pmid17347662>{{Cite journal  | last1 = Mayer | first1 = EK. | last2 = Beckley | first2 = I. | last3 = Winkler | first3 = MH. | title = Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications. | journal = Nat Clin Pract Urol | volume = 4 | issue = 3 | pages = 167-71 | month = Mar | year = 2007 | doi = 10.1038/ncpuro0725 | PMID = 17347662 }}</ref><ref name=dermcdlib_lelc>URL: [http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html]. Accessed on: 11 May 2011.</ref>


Epidemiology:
Epidemiology:
*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>
*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>


Etiology:
Etiology:
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Notes:
Notes:
*The (macroscopic, microscopic, epidemiologic, prognostic)) features of LELC are very similar to ''medullary carcinoma'' -- EBV status is one differentiator.<ref name=pmid7726142>{{Cite journal  | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi =  | PMID = 7726142 }}</ref>
*The (macroscopic, microscopic, epidemiologic, prognostic) features of LELC are very similar to ''medullary carcinoma'' -- EBV status is one differentiator.<ref name=pmid7726142>{{Cite journal  | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi =  | PMID = 7726142 }}</ref>


==Microscopic==
==Microscopic==

Revision as of 13:49, 12 May 2011

Lymphoepithelioma-like carcinoma, abbreviated LELC, is a very rare, poorly differentiated, malignant epithelial tumour.

General

It is thought to be related to nasopharyngeal carcinoma (AKA lymphoepithelioma).[1][2]


Epidemiology:

  • Common in Inuit and some Asians.[3]


Etiology:

  • Associated with EBV,[1] in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland); the skin and uterine cervix appear to be exceptions.[4]
    • The exception to the exception: there is a case report of EBV in LELC of the skin.[5]


Notes:

  • The (macroscopic, microscopic, epidemiologic, prognostic) features of LELC are very similar to medullary carcinoma -- EBV status is one differentiator.[4]

Microscopic

Features:

  • Clusters of cohesive squamoid cells with:
    • Aundant dense eosinophilic cytoplasm.
    • Central nuclei +/- small/indistinct nucleoli.
    • Surrounded by a prominent lymphoid component - key feature.

DDx:

Images:

See also

References

  1. ↑ 1.0 1.1 Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167-71. doi:10.1038/ncpuro0725. PMID 17347662.
  2. ↑ 2.0 2.1 URL: http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html. Accessed on: 11 May 2011.
  3. ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7. Accessed on: 11 May 2011.
  4. ↑ 4.0 4.1 Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction.". Am J Clin Pathol 103 (4): 449-52. PMID 7726142.
  5. ↑ Aoki, R.; Mitsui, H.; Harada, K.; Kawamura, T.; Shibagaki, N.; Tsukamoto, K.; Murata, S.; Shimada, S. (Apr 2010). "A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection.". J Am Acad Dermatol 62 (4): 681-4. doi:10.1016/j.jaad.2008.07.024. PMID 20227583.
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