Difference between revisions of "Lymphoepithelioma-like carcinoma"
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*Associated with [[EBV]],<ref name=pmid17347662/> | *Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland); the skin and [[uterine cervix]] appear to be exceptions.<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | ||
Notes: | |||
*The (macroscopic, microscopic, epidemiologic, prognostic)) features of LELC are very similar to ''medullary carcinoma'' -- EBV status is one differentiator.<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 13:43, 12 May 2011
Lymphoepithelioma-like carcinoma, abbreviated LELC, is a very rare, poorly differentiated, malignant epithelial tumour.
General
It is thought to be related to nasopharyngeal carcinoma (AKA lymphoepithelioma).[1][2]
Epidemiology:
- Common in Inuit and some Asians.[3]
Etiology:
- Associated with EBV,[1] in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland); the skin and uterine cervix appear to be exceptions.[4]
Notes:
- The (macroscopic, microscopic, epidemiologic, prognostic)) features of LELC are very similar to medullary carcinoma -- EBV status is one differentiator.[4]
Microscopic
Features:
- Clusters of cohesive squamoid cells with:
- Aundant dense eosinophilic cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Surrounded by a prominent lymphoid component - key feature.
DDx:
Images:
See also
References
- ↑ 1.0 1.1 Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167-71. doi:10.1038/ncpuro0725. PMID 17347662.
- ↑ 2.0 2.1 URL: http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html. Accessed on: 11 May 2011.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7. Accessed on: 11 May 2011.
- ↑ 4.0 4.1 Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction.". Am J Clin Pathol 103 (4): 449-52. PMID 7726142.