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Difference between revisions of "Lymph node pathology"
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(→Systemic lupus erythematosus lymphadenopathy: split out) |
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*Neoplastic - lymphoma, carcinoma. | *Neoplastic - lymphoma, carcinoma. | ||
*Endocrine - [[hyperthyroidism]]. | *Endocrine - [[hyperthyroidism]]. | ||
*Trauma. | *Trauma. | ||
*Autoimmune - [[SLE]], [[RA]], [[dermatomyositis]]. | *Autoimmune - [[SLE]], [[RA]], [[dermatomyositis]]. | ||
*Inflammatory - drugs (phenytoin). | *Inflammatory - drugs (phenytoin). | ||
| Line 70: | Line 70: | ||
| melanin-laden histiocytes | | melanin-laden histiocytes | ||
| [[histiocytosis]] | | [[histiocytosis]] | ||
| | | [[S-100]]+ve (interdigitating dendritic cells), CD1a+ve (Langerhans cells) | ||
| [[cutaneous T-cell lymphoma]] | | [[cutaneous T-cell lymphoma]] | ||
| [[Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg |thumb|center|150px| DL - intermed. mag.]] | | [[Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg |thumb|center|150px| DL - intermed. mag.]] | ||
| Line 76: | Line 76: | ||
| [[Kimura disease]] | | [[Kimura disease]] | ||
| eosinophils | | eosinophils | ||
| angiolymphoid proliferation (thick-walled blood vessels with hobnail endothelial cells) | | angiolymphoid proliferation (thick-walled blood vessels with [[hobnail]] endothelial cells) | ||
| IHC ? | | IHC ? | ||
| [[Langerhans cell histiocytosis]], drug reaction, [[angiolymphoid hyperplasia with eosinophilia]] | | [[Langerhans cell histiocytosis]], drug reaction, [[angiolymphoid hyperplasia with eosinophilia]] | ||
| Line 84: | Line 84: | ||
| abundant histiocytes with reniform nuclei | | abundant histiocytes with reniform nuclei | ||
| often prominent eosinophilia | | often prominent eosinophilia | ||
| | | [[S-100]]+, CD1a+ | ||
| [[Kimura disease]] (eosinophilia), [[Rosai-Dorfman disease]] | | [[Kimura disease]] (eosinophilia), [[Rosai-Dorfman disease]] | ||
| [[Image:Langerhans_cell_histiocytosis_-_very_high_mag.jpg|thumb|center|150px|LCH - very high mag.]] | | [[Image:Langerhans_cell_histiocytosis_-_very_high_mag.jpg|thumb|center|150px|LCH - very high mag.]] | ||
| Line 91: | Line 91: | ||
| sinus histiocytosis | | sinus histiocytosis | ||
| emperipolesis (intact cell within a macrophage) | | emperipolesis (intact cell within a macrophage) | ||
| | | [[S-100]]+, CD1a- | ||
| Langerhans cell histiocytosis | | Langerhans cell histiocytosis | ||
| [[Image:Emperipolesis_-_very_high_mag.jpg |thumb|center|150px | RDD - very high mag.]] | | [[Image:Emperipolesis_-_very_high_mag.jpg |thumb|center|150px | RDD - very high mag.]] | ||
| Line 200: | Line 200: | ||
===IHC=== | ===IHC=== | ||
Screening panel: | Screening panel: | ||
*CD3. | *[[CD3]]. | ||
*CD5. | *[[CD5]]. | ||
*CD10. | *CD10. | ||
*CD20. | *[[CD20]]. | ||
*CD30. | *CD30. | ||
*CD15. | *CD15. | ||