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Difference between revisions of "Lymph node pathology"
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→Reactive follicular hyperplasia
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***Variable lymphocyte morphology. | ***Variable lymphocyte morphology. | ||
***Tingible-body macrophage (large, pale cells with junk in the cytoplasm). | ***Tingible-body macrophage (large, pale cells with junk in the cytoplasm). | ||
***Germinal centers (GCs) have a crisp/sharp edge. | |||
***Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker. | |||
**Rim of small (inactive) lymphocytes. | **Rim of small (inactive) lymphocytes. | ||
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Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)]. | Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)]. | ||
====Follicular lymphoma vs. reactive follicular hyperplasia==== | |||
Factors to consider:<ref>DB. 4 August 2010.</ref> | |||
{| class="wikitable" | |||
! | |||
! Reactive follicular hyperplasia | |||
! Follicular lymphoma | |||
|- | |||
| Follicle location | |||
| cortex | |||
| cortex and medulla | |||
|- | |||
| Germinal center edge | |||
| sharp/well-demarcated | |||
| poorly demarcated | |||
|- | |||
| Germinal center density | |||
| well spaced | |||
| crowded | |||
|- | |||
| Tingible body macrophages | |||
| common | |||
| uncommon | |||
|- | |||
| Light/dark pattern | |||
| normal | |||
| abnormal | |||
|} | |||
==Diffuse paracortical hyperplasia== | ==Diffuse paracortical hyperplasia== | ||