Difference between revisions of "Lung transplant pathology"
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'''Lung transplant pathology''' is a little subspecialty in the subspecialty of [[lung]] pathology. | '''Lung transplant pathology''' is a little subspecialty in the subspecialty of [[lung]] pathology. | ||
==Classification - rejection== | |||
Types:<ref name=pmid18096473>{{cite journal |author=Stewart S, Fishbein MC, Snell GI, ''et al.'' |title=Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection |journal=J. Heart Lung Transplant. |volume=26 |issue=12 |pages=1229–42 |year=2007 |month=December |pmid=18096473 |doi=10.1016/j.healun.2007.10.017 |url=}}</ref> | |||
*A. Acute rejection. | |||
**A0 (none), A1 (minimal), A2 (mild), A3 (moderate), A4 (severe). | |||
*B. Small airway inflammation/lymphocytic bronchiolitis. | |||
**B0 (none), B1R (low-grade), B2R (high-grade), BX (cannot be graded). | |||
*C. Chronic airway rejection - broncholitis obliterans. | |||
**C0 (absent), C1 (present). | |||
*D. Chronic vascular rejection. | |||
==Rejection== | ==Rejection== | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>{{Ref PPP|407}}</ref> | Features:<ref name=Ref_PPP407>{{Ref PPP|407}}</ref> | ||
*Perivascular lymphocytes / plasmacytoid cells. | *Perivascular lymphocytes / plasmacytoid cells. | ||
*+/-Macrophages. | *+/-Macrophages. | ||
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*[http://commons.wikimedia.org/wiki/File:Lung_transplant_rejection_-_intermed_mag.jpg Rejection - intermed. mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Lung_transplant_rejection_-_intermed_mag.jpg Rejection - intermed. mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Lung_transplant_rejection_-_very_high_mag.jpg Rejection - very high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Lung_transplant_rejection_-_very_high_mag.jpg Rejection - very high mag. (WC)]. | ||
==Post-transplant lymphoproliferative disorder== | |||
{{Main|Post-transplant lymphoproliferative disorder}} | |||
*A rare complication of transplants. | |||
*Similar to [[DLBCL]]. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{reflist| | {{reflist|2}} | ||
[[Category:Pulmonary pathology]] | [[Category:Pulmonary pathology]] | ||
Latest revision as of 19:35, 10 February 2011
Lung transplant pathology is a little subspecialty in the subspecialty of lung pathology.
Classification - rejection
Types:[1]
- A. Acute rejection.
- A0 (none), A1 (minimal), A2 (mild), A3 (moderate), A4 (severe).
- B. Small airway inflammation/lymphocytic bronchiolitis.
- B0 (none), B1R (low-grade), B2R (high-grade), BX (cannot be graded).
- C. Chronic airway rejection - broncholitis obliterans.
- C0 (absent), C1 (present).
- D. Chronic vascular rejection.
Rejection
General
- Usual DDx is infection.
Microscopic
Features:[2]
- Perivascular lymphocytes / plasmacytoid cells.
- +/-Macrophages.
- +/-Eosinophils.
- +/-Neutrophils.
Images:
Post-transplant lymphoproliferative disorder
Main article: Post-transplant lymphoproliferative disorder
- A rare complication of transplants.
- Similar to DLBCL.
See also
References
- ↑ Stewart S, Fishbein MC, Snell GI, et al. (December 2007). "Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection". J. Heart Lung Transplant. 26 (12): 1229–42. doi:10.1016/j.healun.2007.10.017. PMID 18096473.
- ↑ Leslie, Kevin O.; Wick, Mark R. (2004). Practical Pulmonary Pathology: A Diagnostic Approach (1st ed.). Churchill Livingstone. pp. 407. ISBN 978-0443066313.